Photocatalytic Generation of Carbocation from Thiols and Application to Cross-Nucleophile Coupling

Organic Letters, Journal Year: 2024, Volume and Issue: 26(20), P. 4286 - 4291

Published: May 9, 2024

Represented herein is a simple thiol identified as an effective precursor to photochemically form carbocation. Thanks the thiyl radical rapid transformation disulfide, which serves not only stabilize generated but also allow second electron transfer The resulting carbocations, including primary benzylic, secondary, and tertiary can smoothly couple with nitrogen, oxygen, carbon nucleophilic coupling partners well complex drug molecules, accompanied by elemental sulfur formation in air.

Language: Английский

Chiral pyrrolidines via an enantioselective Hofmann-Löffler-Freytag reaction

Chem Catalysis, Journal Year: 2024, Volume and Issue: 4(12), P. 101149 - 101149

Published: Oct. 16, 2024

Language: Английский

Diverting the Mannich reaction to access 2,2-disubstituted indolin-3-ones by merging 1,2-aryl migration and copper-catalyzed aerobic oxidation

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(11), P. 3186 - 3195

Published: Jan. 1, 2024

Three typical substrates for the Mannich reaction, p -anisidine, aldehyde, and a nucleophile, did not afford predictable linear base under an aerobic copper oxidation condition, but rendering 2,2-disubstituted indolin-3-one product.

Language: Английский