Construction of Biaryl Sulfonamides via Pd(II)-Catalyzed Cross-Coupling of C(sp²)-H Bonds with Iodobenzenesulfonamides

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Language: Английский

Fluorene and Fluorenone Unnatural Amino Acid Motifs via Diastereoselective Pd(II)‐Catalyzed sp³C−H Functionalization

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(23)

Published: April 17, 2024

Abstract This paper reports the construction of racemic and enantiopure (D‐ L‐) fluorene fluorenone‐based novel unnatural amino acid derivatives. The Pd(II)‐catalyzed bidentate directing group‐aided arylation prochiral β ‐C(sp 3 )‐H bonds in racemic, carboxamides acids with iodofluorenes was reported. examples fluorenone motifs containing comprising norvaline, leucine, phenylalanine, norleucine, 2‐aminooctanoic derivatives having anti ‐stereochemistry (with good enantiopurity) accomplished. bis fluorenyl alanine scaffolds motif‐containing non‐ α ‐amino (aminoalkanoic acid) also Examples removal group (8‐aminoquinoline) phthalimide‐protecting present fluorenyl‐based have been shown. Accordingly, motif‐based esters free group‐containing were synthesized. stereochemistry major ( ) diastereomers obtained via ascertained from X‐ray structure a representative compound. Fluorene‐ are vital skeletons materials medicinal chemistry research. this work is contribution towards enriching library scaffolds.

Language: Английский

Synthesis of biaryl-based carbazoles via C-H functionalization and exploration of their anticancer activities

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(45), P. 8916 - 8944

Published: Jan. 1, 2024

We described the application of C–H functionalization for constructing carbazole-based biaryls and their anticancer activities in cancer cell lines, e.g. , HeLa, HCT116, MDA-MB-231 MDA-MB-468 human embryonic kidney line HEK293T.

Language: Английский