Asian Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 13(11)

Published: Aug. 28, 2024

Abstract The poor nucleofugality of the amino group renders C−N bond functionalization primary aromatic amines highly challenging. Herein, we report a direct substitution reaction 2‐aminotropones, bearing unique non‐benzenoid seven‐membered ring that exists in some natural products and bioactive molecules, with potassium allyltrifluoroborates through cleavage under transition‐metal‐free conditions. 2‐aminotropones were directly substituted presence sodium bicarbonate, delivering structurally diverse 2‐allyltropones moderate to good yields. is free directing groups, activating groups transition metals, providing convenient method access tropones.

Language: Английский