Silver-Catalyzed Markovnikov Addition Hydrofunctionalization of Terminal Alkynes: Synthesis of N-Enoxyimides and Oximes DOI

Hafiz Noor,

Shuwei Zhang, Xiaodong Jia

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

N-Enoxyimides are versatile and valuable synthetic synthons in modern organic synthesis catalysis. Herein, a silver-catalyzed hydrooxyimidation of terminal alkynes that enables the N-enoxyimides, has been demonstrated. The protocol features simple, step- atom-efficient, scalable, exhibit broad scope functional group tolerance under mild conditions. A novel hydrolysis N-enoxyimides unexpectedly provides corresponding aromatic oximes 96% yield, showing potential application this strategy.

Language: Английский

Efficient and Regioselective Synthesis of Ortho-Diiodinated Homobenzylic Alcohol Derivatives: In-Silico Evaluation as Potential Anticancer IDO/TDO Inhibitors DOI
Raed M. Al‐Zoubi, Walid K. Al‐Jammal, Mohanad Shkoor

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(36), P. 7395 - 7410

Published: Jan. 1, 2024

A direct and highly regioselective method for synthesizing 2,6-diiodophenylethanol is presented. In silico analysis shows compounds 7a, 7p, 7t, 7z interact favourably with IDO/TDO receptors, highlighting their unmatched anticancer potential.

Language: Английский

Citations

2
Manganese-Catalyzed Cycloalkene Ring Expansion Synthesis of Azaheterocycles DOI
Zhixin Wang, Hanxiao Xu,

Xuanzhen Han

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

Herein, a Mn catalytic protocol has been developed for the cycloalkene ring expansion synthesis of azaheterocycles, allowing broad-substrate-scope access to pyridine and isoquinoline derivatives. The initial monoaddition an azidyl radical alkene further as-generated C-radical addition O

Language: Английский

Citations

1
Silver-Catalyzed Markovnikov Addition Hydrofunctionalization of Terminal Alkynes: Synthesis of N-Enoxyimides and Oximes DOI

Hafiz Noor,

Shuwei Zhang, Xiaodong Jia

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

N-Enoxyimides are versatile and valuable synthetic synthons in modern organic synthesis catalysis. Herein, a silver-catalyzed hydrooxyimidation of terminal alkynes that enables the N-enoxyimides, has been demonstrated. The protocol features simple, step- atom-efficient, scalable, exhibit broad scope functional group tolerance under mild conditions. A novel hydrolysis N-enoxyimides unexpectedly provides corresponding aromatic oximes 96% yield, showing potential application this strategy.

Language: Английский

Citations

0