Systematic screening of photopolymer resins for stereolithography (SLA) 3D printing of solid oral dosage forms: Investigation of formulation factors on printability outcomes

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 653, P. 123862 - 123862

Published: Feb. 2, 2024

Pharmaceutical three-dimensional printing (3DP) is now in its golden age. Recent years have seen a dramatic increase the research 3D printed pharmaceuticals due to their potential deliver highly personalised medicines, thus revolutionising way medicines are designed, manufactured, and dispensed. A particularly attractive 3DP technology used manufacture stereolithography (SLA), which features key advantages terms of resolution compatibility with thermolabile drugs. Nevertheless, enthusiasm for pharmaceutical SLA has not been followed by introduction novel excipients specifically designed fabrication medicines; hence, choice biocompatible polymers photoinitiators available limited. This work provides an insight on how maximise usefulness limited materials evaluating different formulation factors affect printability outcomes medicines. 156 photopolymer formulations were systematically screened evaluate influence including photoinitiator amount, molecular size, type amount liquid filler outcomes. Collectively, these found influential modulating print quality final dosage forms. Findings provide enhanced understanding parameters informing future revolution.

Language: Английский

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Electronic substituent effects on ketocoumarin-based photoinitiators: Structure-activity relationships for high-efficiency LED photopolymerization

Progress in Organic Coatings, Journal Year: 2025, Volume and Issue: 204, P. 109229 - 109229

Published: March 17, 2025

Language: Английский

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Visible light-crosslinked gelatin methacryloyl/hyaluronic acid methacryloyl hydrogels with chlorophyll for tissue regeneration

Applied Materials Today, Journal Year: 2025, Volume and Issue: 44, P. 102733 - 102733

Published: April 17, 2025

Language: Английский

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Biomass-derived Photoresins for Digital Light Processing 3D Printing of Degradable Objects

ACS Sustainable Resource Management, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Language: Английский

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Confinement of Sustainable Carbon Dots Results in Long Afterglow Emitters and Photocatalyst for Radical Photopolymerization

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: April 3, 2024

Sustainable carbon dots based on cellulose, particularly carboxymethyl cellulose (CMCCDs), were confined in an inorganic network resulting CMCCDs@SiO

Language: Английский

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Evaluating the polymerization effectiveness and biocompatibility of bio‐sourced, visible light‐based photoinitiator systems

Journal of Biomedical Materials Research Part A, Journal Year: 2024, Volume and Issue: 112(10), P. 1662 - 1674

Published: April 4, 2024

The use of photopolymerization is expanding across a multitude biomedical applications, from drug delivery to bioprinting. Many these current and emerging systems employ visible light, as motivated by safety energy efficiency considerations. However, the "library" light initiators limited compared with wealth options available for UV polymerization. Furthermore, synthesis traditional photoinitiators relies on diminishing raw materials, several are considered environmental contaminants. As such, there has been recent focus identifying characterizing biologically sourced, light-based photoinitiator that can be effectively used in applications. In this regard, bio-sourced molecules have shown act photoinitiators, primarily through Type II photoinitiation mechanisms. whether also effective synergists reactions remains unknown. study, we evaluated effectiveness synergist candidates, amino acids, due their amine functional groups, combination two molecules: riboflavin curcumin. We tested under both violet (405 nm) blue (460-475 using photo-rheology. found namely lysine, arginine, histidine, increased polymerization when light. With curcumin, almost all candidates slightly decreased curcumin alone sources. These results show potential photopolymerization. more work must done fully characterize investigate candidates. Ultimately, information expected expand range increase sustainability.

Language: Английский

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Type I Photoinitiator Based on Sustainable Carbon Dots

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(29)

Published: April 29, 2024

Abstract Sustainable carbon dots comprising surficial oxime ester groups following homolytic bond cleavage exhibit potential as photoinitiators for traditional free radical photopolymerization. Carbon were made a solvothermal procedure from sustainable furfural available lignocellulose. Surficial aldehyde moieties reacted with hydroxylamine to the respective while reaction benzoyl chloride resulted in biobased Type I photoinitiator dot ( CD ‐ PI ). Photoinitiating ability was compared ) ethyl (2,4,6‐trimethyl benzoyl) phenyl phosphinate TPO L by real‐time FTIR UV exposure at 365 nm. Photopolymer composition based on mixture of urethane dimethacrylate UDMA and tripropylene glycol diacrylate TPGDA similar final conversion about 70 % using either CD‐PI or TPO‐L . Nevertheless, it appeared homogeneous case compositions processed , those heterogeneous shown two glass transition temperatures. Moreover, migration rate cured samples lower comparison

Language: Английский

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Toxicity of stereolithography 3D printed objects at the chemical level and strategies to improve biocompatibility

Additive manufacturing, Journal Year: 2025, Volume and Issue: unknown, P. 104715 - 104715

Published: Feb. 1, 2025

Language: Английский

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Flavonoid-Based Nanogels: A Comprehensive Overview

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 267 - 267

Published: April 4, 2025

The growing field of nanotechnology has recently given much attention to nanogels, which are versatile formulas and have promising biomedical applications. Nanogels or nanohydrogels undergone significant development in various fields industrial research meet increasing demands, such as pharmaceuticals, cosmetics, food, genetic engineering. that contain flavonoids, secondary metabolites found plants, starting become distinctive reveal their unique characteristics. objective the article is provide a comprehensive overview recent articles on flavonoid-based emphasizing general aspects regarding nanogel formulation structural characterization, well advancements made field. In conclusion, this outlines up-to-date developments synthesis, formulation, therapeutic applications important role nanotechnology.

Language: Английский

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Dual role of novel highly efficient radical generators for UV/LED-activated polymerization processes

Polymer Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This study reports novel diphenyliodonium tosylates (IODs) as highly effective photoinitiators for the radical polymerization of (meth)acrylates.

Language: Английский

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