Recent Advances in the Electrochemical Functionalization of Imidazoheterocycles DOI
Sifeng Li

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 18, 2024

Abstract Imidazoheterocycles have extensive applications in the pharmaceutical industry and agrochemicals. A comprehensive overview has been provided on current advancements electrochemical functionalization of imidazo‐fused heterocycles, which classified into ten different types reactions. Electrochemical synthesis emerged as a highly effective method for producing organic molecules, especially context sustainable development. Employing electrons traceless oxidant, several C−H reactions heterocycles achieved at either C3 or C5 positions. Electrons may serve reducing agent to synthesize pyridine rings that are partially fully saturated imidazo[1,2‐ ]pyridines. The purpose review is attract interest scientific community promote additional research imidazoheterocycles using methods.

Language: Английский

Electrosynthesis of 1,4-diene derivatives bearing cyclopentene skeleton DOI Creative Commons

Yaqi Qiao,

Xiaoqing Fan,

Chengcheng Yuan

et al.

iScience, Journal Year: 2025, Volume and Issue: 28(3), P. 111976 - 111976

Published: Feb. 10, 2025

1,n-Dual Π systems including 1,4-diene derivatives have been widely used as the elegant radical receptors to promote cascade additions give highly functionalized polycyclic scaffolds. However, tedious and complicated preparation of former deters broad utilization compromises practical value. Herein, a straightforward was developed from easily accessible alkynes γ,δ-unsaturated carboxylic acids via electrochemical oxidation cyclization Hofmann elimination. This transformation features with good excellent yields, functional group compatibility, selectivity without any Zaitsev elimination product detected.

Language: Английский

Citations

0
Photoredox-Cobaloxime Catalysis for Selective Oxidative Dehydrogenative [4+2] Annulation of Imidazo-Fused Heterocycles with Alkenes DOI
Ailong Shao, Yuanyuan Li,

Yuxue Ding

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(13), P. 2529 - 2534

Published: March 21, 2024

A selective oxidative [4+2] annulation of alkenes with imidazo-fused heterocycles has been developed by using the synergistic combination photoredox and cobaloxime catalysts. It allows facile access to various imidazole-fused polyaromatic scaffolds accompanied H2 evolution. This protocol features high regioselectivity as well a broad substrate scope. Detailed mechanistic studies indicate that twice electron/H transfer processes facilitated this catalytic system achieve π-extension alkenes.

Language: Английский

Citations

2
Electrosynthesis of Highly Functionalized Polycyclic N-Heteroaromatics through Cascade Radical Cyclization and Alkoxylation in Batch and Continuous-Flow DOI
Jiawei Chen,

Yaqi Qiao,

Wenjing Guan

et al.

ACS Sustainable Chemistry & Engineering, Journal Year: 2023, Volume and Issue: 11(50), P. 17728 - 17738

Published: Dec. 6, 2023

Electrochemical radical cascade cyclization has been recognized as a powerful, straightforward, and environmentally-friendly synthetic tool to give highly functionalized polycyclic aromatic compounds but remains challenging difficult because of the instability intermediates under electrolysis conditions, especially using user-friendly undivided cell. Herein, we report novel electrosynthesis pyridine-fused N-heteroaromatics through dehydrogenative alkoxylation oxidant-free conditions. This electrochemical synthesis methodology features green mild reaction good functional group tolerance, use readily available substrates. Moreover, attributed flow cells, steady production large-scale preparation can be conveniently achieved only small amounts electrolytes.

Language: Английский

Citations

4
De novo synthesis of 6-6-5 fused-systems through electrochemical decarboxylation and radical domino additions DOI

Chengcheng Yuan,

Guanru Liu,

Wenjing Guan

et al.

Green Chemistry, Journal Year: 2024, Volume and Issue: 26(19), P. 10308 - 10313

Published: Jan. 1, 2024

An oxidant and quaternary ammonium salt-free electrosynthesis of 6-6-5 fused systems was developed with excellent atom step economy.

Language: Английский

Citations

1
Recent Advances in the Electrochemical Functionalization of Imidazoheterocycles DOI
Sifeng Li

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 18, 2024

Abstract Imidazoheterocycles have extensive applications in the pharmaceutical industry and agrochemicals. A comprehensive overview has been provided on current advancements electrochemical functionalization of imidazo‐fused heterocycles, which classified into ten different types reactions. Electrochemical synthesis emerged as a highly effective method for producing organic molecules, especially context sustainable development. Employing electrons traceless oxidant, several C−H reactions heterocycles achieved at either C3 or C5 positions. Electrons may serve reducing agent to synthesize pyridine rings that are partially fully saturated imidazo[1,2‐ ]pyridines. The purpose review is attract interest scientific community promote additional research imidazoheterocycles using methods.

Language: Английский

Citations

1