Organic Letters,
Journal Year:
2025,
Volume and Issue:
27(6), P. 1561 - 1567
Published: Jan. 31, 2025
An
electrochemically
driven
Ugi-azide
reaction
was
established
via
C(sp3)-H
bond
activation
of
tertiary
amines
to
prepare
α-aminomethyl
tetrazoles
within
2.5
h
under
mild
conditions
with
remarkable
tolerance
various
functional
groups.
Besides,
this
electrochemical
strategy
not
only
obviated
the
needs
iodine,
metal,
and
exogenous
oxidant
but
possessed
potential
applicability
convenient
large-scale
synthesis.
Mechanistic
studies
indicated
both
alkyl
carbon-centered
radical
generated
at
anode
intramolecular
[3
+
2]
cycloaddition
are
key
factors
for
strategy.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(11), P. 7531 - 7540
Published: May 18, 2024
An
organocatalyzed
photoelectrochemical
method
for
the
generation
of
acyl
and
phosphoryl
radicals
from
formamides,
aldehydes,
phosphine
oxides
has
been
developed.
This
protocol
utilizes
9,10-phenanthrenequinone
(PQ)
as
both
a
molecular
catalyst
hydrogen
atom-transfer
(HAT)
reagent,
eliminating
requirement
external
metal-based
reagents,
HAT
oxidants.
The
generated
can
be
applied
to
range
radical-mediated
transformation
reactions,
including
C–H
carbamoylation
heteroarenes,
intermolecular
tandem
radical
cyclization
CF3-substituted
N-arylacrylamides,
well
intramolecular
reactions.
use
in
these
transformations
offers
an
efficient
sustainable
approach
accessing
structurally
diverse
carbonyl
compounds.
Heliyon,
Journal Year:
2023,
Volume and Issue:
9(9), P. e19659 - e19659
Published: Aug. 31, 2023
In
this
research,
zinc
oxide
(ZnO)
nanoparticles
doped
with
different
percentages
of
produced
cobalt
using
the
green
synthesis
method.
ZnO
showed
good
cellular
and
microbial
toxicity
due
to
their
high
surface-to-volume
ratio.
Adding
metal
nanostructure
can
lead
appearance
a
new
feature.
To
investigate
effect
adding
metal,
synthesized
containing
3
6%
were
plant
extract.
The
resulting
nanostructures
characterized
by
Raman
spectroscopy,
UV–Visible
spectrometer,
X-ray
diffraction,
Field
emission
scanning
electron
microscopy.
Ultimately,
samples'
cytotoxicity
antimicrobial
tests
performed.
XRD
confirmed
formation
hexagonal
wurtzite
structure.
imaging
that
doping
resulted
in
decrease
average
crystal
size.
results
doping,
particle
size
decreased
slightly.
effects
all
three
studies,
leads
an
increase
compared
non-doped
nanoparticles.
Polycyclic aromatic compounds,
Journal Year:
2023,
Volume and Issue:
44(7), P. 4932 - 4978
Published: Sept. 13, 2023
AbstractThe
synthesis
of
heterocyclic
compounds
is
always
one
the
most
important
challenges
among
synthetic
chemists.
Pyranopyrazoles
are
an
class
that
a
rich
source
biologically
molecules.
These
derivatives
present
as
key
structures
in
natural
products,
bioactive,
and
biological
So
far,
many
catalytic
systems
methods
have
been
reported
for
these
compounds.
However,
pyranopyrazoles
through
multicomponent
reactions
great
importance,
especially
from
point
view
green
chemistry.
During
last
decade,
use
magnetic
materials
catalysts
organic
compounds,
heterocycles,
has
created
huge
revolution
The
easy
fast
separation
nanocatalysts
using
only
external
magnet
advantage
this
type
catalyst,
addition
to
complete
catalyst
field,
ability
be
reused,
which
leads
cost
reduction
savings.
This
paper
covers
applications
magnetically
recoverable
nanoparticles
pyranopyrazole
derivatives.
In
review,
we
discussed
on
detials
conditions
well
presented
mechanisms
their
preparation
presence
nanomagnetic
reusable
catalysts.Keywords:
Pyranopyrazolesmagnetic
nancatalystsmagnetic
seperationmulticomonent
reactionssynthetic
chemistry
Disclosure
statementNo
potential
conflict
interest
was
by
author(s).
Organic Letters,
Journal Year:
2025,
Volume and Issue:
27(6), P. 1561 - 1567
Published: Jan. 31, 2025
An
electrochemically
driven
Ugi-azide
reaction
was
established
via
C(sp3)-H
bond
activation
of
tertiary
amines
to
prepare
α-aminomethyl
tetrazoles
within
2.5
h
under
mild
conditions
with
remarkable
tolerance
various
functional
groups.
Besides,
this
electrochemical
strategy
not
only
obviated
the
needs
iodine,
metal,
and
exogenous
oxidant
but
possessed
potential
applicability
convenient
large-scale
synthesis.
Mechanistic
studies
indicated
both
alkyl
carbon-centered
radical
generated
at
anode
intramolecular
[3
+
2]
cycloaddition
are
key
factors
for
strategy.
