One-Pot Sequential Synthesis of Alkenylated Dihydroquinolinones and Hexahydroacridinones in Deep Eutectic Solvent Medium

ACS Omega, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 16, 2024

The sequential synthesis of N-heterocycles from saturated ketones poses significant challenges and has rarely been reported. Herein, an efficient alkenylated dihydroquinolinones 7 hexahydroacridinones 8 is achieved 1 or 2 via dehydrogenation, cyclization, oxidation, α-alkenylation in choline chloride-based deep eutectic solvent (DES) medium. This strategy provides excellent yield low-cost, readily available starting materials under environmentally benign conditions. Furthermore, the synthesized compounds (4, 5, 7, 8) were investigated for their photophysical properties through absorption emission spectral studies.

Language: Английский

---

Multicomponent synthesis of functionalized pyrrolo[3,4-e]isoindole-1,3,6,8-tetraones via [2 + 2 + 2] cycloaddition of maleimides with nitroenamines

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(21), P. 6144 - 6149

Published: Jan. 1, 2024

We developed a protocol for the synthesis of PIITOs from maleimides and nitroenamines. This strategy featured [2 + 2 2] cycloaddition with heating mixture substrates 1 DMF without any catalyst.

Language: Английский

---

Radical Cascade Reaction of Heterocyclic Ketene Aminals with Thiocyanates Promoted by Visible Light: Synthesis of Functionalized Fused 2-Iminothiazolines

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(18), P. 13678 - 13690

Published: Sept. 6, 2024

Herein, a visible-light-promoted radical cascade cyclization of heterocyclic ketene aminals (HKAs) and thiocyanates was developed to access functionalized fused 2-iminothiazolines. This novel reaction can be realized under only visible-light irradiation without the help external photocatalysts, oxidants, additives. These multicomponent reactions demonstrate excellent selectivity for

Language: Английский

---