The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
89(1), P. 565 - 575
Published: Dec. 20, 2023
An
array
of
biologically
interesting
tri/difluoromethylated
chromones
and
their
heteroatom
analogues
were
conveniently
synthesized
from
the
reaction
with
CF3SO2Na
or
HCF2SO2Na
in
presence
tert-butyl
hydroperoxide
under
mild
conditions.
A
mechanistic
pathway
involving
generation
electrophilic
tri/difluoromethyl
radical,
followed
radical
substitution
analogues,
was
postulated.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(20), P. 7983 - 7987
Published: Jan. 1, 2023
An
atom-
and
step-economical,
efficient
eco-friendly
method
for
constructing
naphthoselenazol-2-amines
through
a
visible-light
photocatalytic
multi-component
reaction
under
aqueous
phase
conditions
is
reported.
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
42(15), P. 1679 - 1685
Published: March 15, 2024
Comprehensive
Summary
A
novel
and
eco‐friendly
electrochemical
activation
of
trifluoromethyl
thianthrenium
triflate
(TT–CF
3
+
OTf
−
)
for
trifluoromethylation
imidazole‐fused
heteroaromatic
compounds
was
established.
This
method
involves
the
direct
electrolysis
TT–CF
without
requirement
external
oxidants
or
catalysts,
aligning
with
principles
green
chemistry.
wide
range
including
imidazo[1,2‐
a
]pyridines
benzo[
d
]imidazo[2,1‐
b
]thiazoles
have
been
successfully
trifluoromethylated
using
this
technique,
exhibiting
excellent
compatibility
various
functional
groups
broad
substrate
scope.
Moreover,
method's
applicability
one‐pot
sequential
reactions
enables
reduction
waste
resource
consumption
by
eliminating
need
intermediate
purification
steps.
Chinese Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
43(12), P. 4213 - 4213
Published: Jan. 1, 2023
Benzoxazines
are
important
motif
in
pharmaceuticals
and
functional
molecules.A
visible-light
induced
photocatalytic
strategy
for
the
synthesis
of
difluoroethyl
benzoxazines
with
organo-photocatalyst
was
developed.In
present
protocol,
a
series
olefinic
amides
can
be
transferred
to
difluoroethylated
via
oxydifluoromethylation
CF2HSO2Na
as
difluoromethylating
reagent,
which
is
easily
operated
good
group
tolerant.
ChemSusChem,
Journal Year:
2023,
Volume and Issue:
16(19)
Published: Sept. 20, 2023
A
green
and
practical
method
for
the
electrochemical
synthesis
of
tetrahydroimidazo[1,5-a]quinoxalin-4(5H)-ones
through
three-component
reaction
quinoxalin-2(1H)-ones,
N-arylglycines
paraformaldehyde
was
reported.
In
this
strategy,
EtOH
played
dual
roles
(eco-friendly
solvent
waste-free
pre-catalyst)
in
situ
generated
ethoxide
promoted
triple
sequential
deprotonations.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(12), P. 2398 - 2402
Published: March 18, 2024
Herein,
we
introduce
a
tetralone-mediated
photocyclization
method
of
N-arylacrylamides.
The
protocol
proceeds
smoothly
to
deliver
diverse
set
3,4-dihydroquinolinones
in
moderate
good
yields
with
excellent
functional
group
compatibility
and
readily
allows
for
late-stage
modifications
number
complex
drug
molecules.
Mechanistic
studies
reveal
that
the
present
systems
ultraviolet
light
irradiation
enable
cyclization
via
energy
transfer
exclusive
1,3-hydrogen
shift.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(26), P. 28129 - 28143
Published: June 19, 2024
An
efficient
and
mild
protocol
for
the
visible
light-induced
radical
cascade
difluoromethylation/cyclization
of
imidazoles
with
unactivated
alkenes
using
easily
accessible
bench-stable
difluoromethyltriphenylphosphonium
bromide
as
precursor
-CF
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(31)
Published: June 5, 2024
Abstract
During
the
past
decade,
radical
difluoromethylation
has
emerged
as
a
powerful
and
versatile
tool
for
incorporation
of
difluoromethyl
into
various
organic
compounds.
These
reactions
feature
mild
reaction
conditions,
very
good
functional
group
compatibilities,
quite
broad
substrate
scopes,
thus
having
drawn
much
attention
got
rapid
developments.
A
diverse
range
precursors
have
been
developed
series
reactions.
This
review
summarizes
discusses
advance
in
reactions,
which
are
organized
according
to
protocols
generating
radical.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(19), P. 5553 - 5557
Published: Jan. 1, 2024
A
mild
and
efficient
protocol
for
preparing
4-halomethyl
benzoxazines
via
a
photoelectrochemical
process
with
ammonium
halide
as
the
halogenating
reagent
was
developed.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: July 20, 2024
Alkylamine
structures
represent
one
of
the
most
functional
and
widely
used
in
organic
synthesis
drug
design.
However,
general
methods
for
functionalization
shielded
deshielded
alkyl
radicals
remain
elusive.
Here,
we
report
a
deoxygenative
amination
protocol
using
alcohol-derived
carbazates
nitrobenzene
under
electrochemical
conditions.
A
range
primary,
secondary,
tertiary
alkylamines
are
obtained.
This
practical
procedure
can
be
scaled
up
through
continuous
flow
technique.
