RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(1), P. 154 - 159
Published: Jan. 1, 2024
The
introduction
of
trifluoromethyl
(-CF3)
groups
into
compounds
is
a
common
synthetic
strategy
in
organic
chemistry.
Commonly
used
methods
for
introducing
are
limited
by
harsh
reaction
conditions,
low
regioselectivity,
or
the
need
excess
reagents.
In
this
study,
facile
electrochemical
oxidative
and
radical
cascade
cyclization
N-(2-vinylphenyl)amides
synthesis
CF3-containing
benzoxazines
oxazolines
was
obtained.
This
sustainable
protocol
features
inexpensive
durable
electrodes,
wide
range
substrates,
diverse
functional
group
compatibility
under
transition-metal-free,
external-oxidant-free,
additive-free
can
be
applied
an
open
environment.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(20), P. 7983 - 7987
Published: Jan. 1, 2023
An
atom-
and
step-economical,
efficient
eco-friendly
method
for
constructing
naphthoselenazol-2-amines
through
a
visible-light
photocatalytic
multi-component
reaction
under
aqueous
phase
conditions
is
reported.
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
42(15), P. 1679 - 1685
Published: March 15, 2024
Comprehensive
Summary
A
novel
and
eco‐friendly
electrochemical
activation
of
trifluoromethyl
thianthrenium
triflate
(TT–CF
3
+
OTf
−
)
for
trifluoromethylation
imidazole‐fused
heteroaromatic
compounds
was
established.
This
method
involves
the
direct
electrolysis
TT–CF
without
requirement
external
oxidants
or
catalysts,
aligning
with
principles
green
chemistry.
wide
range
including
imidazo[1,2‐
a
]pyridines
benzo[
d
]imidazo[2,1‐
b
]thiazoles
have
been
successfully
trifluoromethylated
using
this
technique,
exhibiting
excellent
compatibility
various
functional
groups
broad
substrate
scope.
Moreover,
method's
applicability
one‐pot
sequential
reactions
enables
reduction
waste
resource
consumption
by
eliminating
need
intermediate
purification
steps.
Chinese Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
43(12), P. 4213 - 4213
Published: Jan. 1, 2023
Benzoxazines
are
important
motif
in
pharmaceuticals
and
functional
molecules.A
visible-light
induced
photocatalytic
strategy
for
the
synthesis
of
difluoroethyl
benzoxazines
with
organo-photocatalyst
was
developed.In
present
protocol,
a
series
olefinic
amides
can
be
transferred
to
difluoroethylated
via
oxydifluoromethylation
CF2HSO2Na
as
difluoromethylating
reagent,
which
is
easily
operated
good
group
tolerant.
ChemSusChem,
Journal Year:
2023,
Volume and Issue:
16(19)
Published: Sept. 20, 2023
A
green
and
practical
method
for
the
electrochemical
synthesis
of
tetrahydroimidazo[1,5-a]quinoxalin-4(5H)-ones
through
three-component
reaction
quinoxalin-2(1H)-ones,
N-arylglycines
paraformaldehyde
was
reported.
In
this
strategy,
EtOH
played
dual
roles
(eco-friendly
solvent
waste-free
pre-catalyst)
in
situ
generated
ethoxide
promoted
triple
sequential
deprotonations.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(12), P. 2398 - 2402
Published: March 18, 2024
Herein,
we
introduce
a
tetralone-mediated
photocyclization
method
of
N-arylacrylamides.
The
protocol
proceeds
smoothly
to
deliver
diverse
set
3,4-dihydroquinolinones
in
moderate
good
yields
with
excellent
functional
group
compatibility
and
readily
allows
for
late-stage
modifications
number
complex
drug
molecules.
Mechanistic
studies
reveal
that
the
present
systems
ultraviolet
light
irradiation
enable
cyclization
via
energy
transfer
exclusive
1,3-hydrogen
shift.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(26), P. 28129 - 28143
Published: June 19, 2024
An
efficient
and
mild
protocol
for
the
visible
light-induced
radical
cascade
difluoromethylation/cyclization
of
imidazoles
with
unactivated
alkenes
using
easily
accessible
bench-stable
difluoromethyltriphenylphosphonium
bromide
as
precursor
-CF
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(31)
Published: June 5, 2024
Abstract
During
the
past
decade,
radical
difluoromethylation
has
emerged
as
a
powerful
and
versatile
tool
for
incorporation
of
difluoromethyl
into
various
organic
compounds.
These
reactions
feature
mild
reaction
conditions,
very
good
functional
group
compatibilities,
quite
broad
substrate
scopes,
thus
having
drawn
much
attention
got
rapid
developments.
A
diverse
range
precursors
have
been
developed
series
reactions.
This
review
summarizes
discusses
advance
in
reactions,
which
are
organized
according
to
protocols
generating
radical.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 10, 2025
A
trifluoromethylpyridylation
of
unactivated
alkenes
in
aqueous
solution
under
open
air
is
reported.
This
process
allows
the
incorporation
trifluoromethyl
and
construction
pyridines
annulated
to
saturated
cycles
via
an
intramolecular
Minisci
reaction
using
Langlois'
reagent
(CF3SO2Na)
as
a
source.
Extrusion
from
not
required.
broad
functional
group
tolerance
observed.
series
five-,
six-,
seven-membered
are
obtained,
exhibiting
great
potential
application
preparation
diversified
pyridines.
