Cascade [3 + 2] Annulation of 1,3-Dicarbonyl Compounds and Ethyl Secondary Amines for Pyrrole Synthesis via Poly C(sp3)–H Bond Functionalization DOI
Xiuli Li, Yunyun Liu, Jie‐Ping Wan

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(21), P. 16049 - 16054

Published: Oct. 21, 2024

The synthesis of polyfunctionalized pyrroles via the cascade reactions 1,3-dicarbonyl compounds and two molecules ethyl secondary amines has been realized simple iodine catalysis in presence Dess-Martin periodinane (DMP). formation target pyrrole products involves one new C-C C-N bonds major functionalization six C(sp

Language: Английский

Mechanosynthesis of polysubstituted pyridines via FeBr3-catalyzed cascade reaction of arylidene isoxazolones with β‑carbonyl esters DOI
Lei Wang, Mingjun Li, Qinghai Li

et al.

Tetrahedron Letters, Journal Year: 2025, Volume and Issue: unknown, P. 155569 - 155569

Published: March 1, 2025

Language: Английский

Citations

0
Five-Component [2 + 2 + 1 + 1] Tandem Benzannulation Leading to Multifunctionalized Aromatic Amines DOI
Hexiang Wang,

Shuting Li,

Xiaoying Wu

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(45), P. 9648 - 9653

Published: Nov. 1, 2024

An unprecedented five-component [2 + 2 1 1] benzannulation strategy for regioselective assembly of densely functionalized aromatic amines from two ynals, malononitriles, and sodium sulfinates is established. The protocol enables the efficient installation five substituents on a benzene ring via formation multiple chemical bonds in single operation, providing various multifunctionalized primary moderate to good yields. Additionally, three-component [3 cycloaddition NH4SCN was also achieved produce 2-amnopyridine derivatives with serving as an ammonia surrogate.

Language: Английский

Citations

3
Cu(II)/Base Synergistic Promoted [2 + 1 + 3] Cyclization of Cyclic Ketones with α,β-Unsaturated Aldehydes/Ketones and NH4I to Access Fused Pyridines DOI
Lu Hao, Xinyu Li,

Yifeng Ou

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(34), P. 7191 - 7195

Published: Aug. 20, 2024

Herein, a practical three-component [2 + 1 3] cyclization of various cyclic ketones with α,β-unsaturated aldehydes/ketones and ammonium iodide (NH4I) to access highly functional fused pyridines has been developed. The features this transformation include mild reaction conditions, readily available starting materials, excellent chemoselectivity. This protocol is compatible groups, the preliminary studies on mechanism are also provided.

Language: Английский

Citations

2
Base-promoted fused β-carboline formation from 2-(1H-indol-3-yl)cyclohexan-1-ones, aldehydes and ammonium salts DOI
Jinjin Chen, Yuxin Zhang, Xinping Liu

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(13), P. 3583 - 3588

Published: Jan. 1, 2024

A novel base-promoted fused β-carboline formation strategy from 2-(1 H -indol-3-yl)cyclohexan-1-ones, aldehydes and ammonium salts has been developed. Ammonium served as nitrogen sources played an important role in selectivity control.

Language: Английский

Citations

1
Copper-Catalyzed Four-Component Domino Cyclization for the Synthesis of 2-Methylpyridines DOI
Yanfeng Ma, Tianci Xu,

Yuezhou Yuan

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(17), P. 11994 - 12000

Published: Aug. 17, 2024

A convenient protocol for synthesis of unsymmetrical 2-methylpyridines from acetyl ketones, ammonium salts and tertiary amines is described. The construction two C–C bonds C–N via [2 + 2 1 1] four-component domino cyclization reaction achieved using Cu(OTf) as catalyst in one pot. This shows good selectivity produces multisubstituted 2-methylpyridine derivatives yields with various functional groups.

Language: Английский

Citations

0
Six-membered ring systems: Pyridines and benzo analogs DOI

Zachary Shultz

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 309 - 354

Published: Jan. 1, 2024

Language: Английский

Citations

0
One-pot synthesis of 2,2′-biquinolines from aromatic amines using oxygen as an oxidant under metal-free conditions DOI
Yunfeng Liao,

Hualan Gao,

Hongrui Qi

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

We have developed an efficient method for the synthesis of unsymmetrical and symmetrical 2,2′-biquinolines under 55% HI-catalyzed conditions using oxygen as oxidant cheap readily available aromatic amines feedstocks in one pot.

Language: Английский

Citations

0
Cascade [3 + 2] Annulation of 1,3-Dicarbonyl Compounds and Ethyl Secondary Amines for Pyrrole Synthesis via Poly C(sp3)–H Bond Functionalization DOI
Xiuli Li, Yunyun Liu, Jie‐Ping Wan

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(21), P. 16049 - 16054

Published: Oct. 21, 2024

The synthesis of polyfunctionalized pyrroles via the cascade reactions 1,3-dicarbonyl compounds and two molecules ethyl secondary amines has been realized simple iodine catalysis in presence Dess-Martin periodinane (DMP). formation target pyrrole products involves one new C-C C-N bonds major functionalization six C(sp

Language: Английский

Citations

0