Design of rigid chiral bipyridine-2NO tetradentate ligands: application in asymmetric catalysis

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(5), P. 1314 - 1321

Published: Jan. 1, 2024

A new class of chiral bipyridine-2NO ligands, which incorporate the advantages both bipyridine skeleton and pyrroloimidazolone-based N -oxide moiety, was developed.

Language: Английский

Skeletal Reorganization of Saturated Six-Membered Aza-cycles to Sulfonated Pyrrolidines under Redox-Neutral Conditions

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Ring contraction in skeletal reorganization strategies is one of the most intriguing yet surprisingly challenging transformations. Herein, we report for first time a ring tandem sulfonation between saturated six-membered N-heterocyclic nitroxides and sulfonyl hydrazides to access sulfonated pyrrolidine derivatives by an electrochemical redox cascade under redox-neutral metal-free conditions, which unavailable via conventional synthetic approaches. This benign approach has been further demonstrated gram-scale preparation pharmaceutical molecule synthesis mild conditions.

Language: Английский

Phen-2NO, a new C₂-symmetric rigid-featured tetradentate ligand, and its application in the asymmetric alkylation reaction of indoles

New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 48(15), P. 6670 - 6675

Published: Jan. 1, 2024

A new class of C 2 -symmetric rigid-featured chiral phen ligands that provide the N , O -tetradentate coordination moiety and two additional -dioxides were rationally designed developed.

Language: Английский