Diazotization-Enabled Deaminative Late-Stage Functionalization of Primary Sulfonamides DOI
Jiang‐Sheng Li, Jia Liu,

Yao-Tian Wang

et al.

Organic Letters, Journal Year: 2023, Volume and Issue: 25(46), P. 8263 - 8268

Published: Nov. 10, 2023

We, for the first time, disclosed a simple and efficient strategy late-stage functionalization of primary sulfonamides by diazotization, leading to sulfonyl chlorides, sulfonates, complex sulfonamides. This protocol obviates requirement prefunctionalization Its applicability is exemplified sulfonamide-type drugs.

Language: Английский

Aminoselenation and Dehydroaromatization of Cyclohexanones with Anilines and Diselenides DOI
Lin Zhao,

Yujie Weng,

Xinyu Zhou

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(22), P. 4835 - 4839

Published: May 29, 2024

A three-component cascade reaction involving cyclohexanones, anilines, and diaryl diselenides under metal-free conditions is reported. The ortho-selenation of cyclohexanones with diselenides, followed by sequential dehydroaromatization enables the preparation a variety o-selanyl anilines in moderate to excellent yields. This innovative transformation notable for its tolerance functional groups suitable late-stage modification complex pharmaceuticals.

Language: Английский

Citations

28
Recent Advances in Deoxygenative Thioether Synthesis Using Oxygenated Sulfur Surrogates DOI
Cong Ma, Long Yin Lam

Synthesis, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Abstract Thioethers (sulfides) play a crucial role in therapeutics, diagnostics, and functional materials. Traditionally, their synthesis involved the use of thiols or derivatives, which are associated with unpleasant odors potential health risks. Recently, significant research has focused on employing oxygenated sulfur compounds, such as sulfinates, sulfonyl oxyacids, sulfoxides, thiol surrogates for thioether synthesis. This review highlights recent advancements deoxygenative synthesis, categorizing them by reaction types, including cross-coupling reactions, C–H functionalization, hydro/halo/oxy-thiolation unsaturated hydrocarbons. We also discuss representative mechanisms to provide comprehensive understanding these innovative approaches. 1 Introduction 2 Cross-Coupling Reactions 3 Functionalization 4 Hydro/Halo/Oxy-thiolation Unsaturated Hydrocarbons 5 Conclusion

Language: Английский

Citations

1
Deep eutectic solvents as sustainable media for multicomponent sulfonylation: an efficient strategy to synthesize (hetero)aryl sulfones DOI
Haibo Zhu, Yangbo Zhong,

Liyuan Yan

et al.

Green Chemistry, Journal Year: 2024, Volume and Issue: 26(3), P. 1387 - 1392

Published: Jan. 1, 2024

A green and sustainable multicomponent sulfonylation starting from boronic acids, K 2 S O 5 halides has been developed using a deep eutectic solvent (DES) as reaction medium.

Language: Английский

Citations

5
Novel C-4 sulfenylated pyrazoles as α-amylase inhibitors: Insights from in silico and in vitro studies DOI

Jyoti,

Suman Devi, Sandhya Chahal

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108615 - 108615

Published: May 1, 2025

Language: Английский

Citations

0
CCl4-Induced Synthesis of Phosphonothioates, Sulfoxides, and Sulfones from Sodium Sulfinates DOI

Xiangyun Yang,

Silong Chen,

Nan Huang

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 22, 2025

An external reductant-free and acid-free synthesis of phosphonothioates from odorless sodium sulfinates induced by CCl4 (1.0 equiv) under mild conditions has been achieved. This transformation provides an efficient synthetic approach to in up 98% yield with good functional group compatibility. In addition, unexpected CCl4-induced sulfoxides sulfones using DMSO as the solvent developed.

Language: Английский

Citations

0
Synthesis of (E)‐β‐Iodovinyl Sulfones via HI‐mediated Vicinal Iodosulfonylation of Alkynes with Sodium Sulfinates DOI

Zu‐Jia Chen,

Yu Zeng,

Zhonghao Li

et al.

Asian Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 13(6)

Published: March 21, 2024

Abstract Hydroiodic acid‐mediated vicinal iodosulfonylation reaction of alkynes with sodium sulfinates is proposed for the synthesis ( E )‐ β ‐iodovinyl sulfones. The method easy to operate, environmentally friendly, using inexpensive and easily available raw materials, giving target products good regio‐ stereoselectivity in satisfactory yields.

Language: Английский

Citations

2
Pushing Boundaries: What’s Next in Metal-Free C–H Functionalization for Sulfenylation? DOI
Payal Rani, Sandhya Chahal,

Rajvir Singh

et al.

Topics in Current Chemistry, Journal Year: 2024, Volume and Issue: 382(2)

Published: April 12, 2024

Language: Английский

Citations

1
Diazotization-Enabled Deaminative Late-Stage Functionalization of Primary Sulfonamides DOI
Jiang‐Sheng Li, Jia Liu,

Yao-Tian Wang

et al.

Organic Letters, Journal Year: 2023, Volume and Issue: 25(46), P. 8263 - 8268

Published: Nov. 10, 2023

We, for the first time, disclosed a simple and efficient strategy late-stage functionalization of primary sulfonamides by diazotization, leading to sulfonyl chlorides, sulfonates, complex sulfonamides. This protocol obviates requirement prefunctionalization Its applicability is exemplified sulfonamide-type drugs.

Language: Английский

Citations

2