Dibenzo‐Fused Heterocycles: A Decade Update on the Syntheses of Carbazole, Dibenzofuran, and Dibenzothiophene DOI
Anjana Sreekumar, Ajil R. Nair,

C. Raksha

et al.

The Chemical Record, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

Abstract Polycyclic heterocycles are the most common and critical structural motifs found in a variety of natural products, medicines, fertilizers, advanced materials. Because their widespread use biologically active compounds material chemistry, functionalised dibenzo heterocyclic compounds, especially dibenzofuran, dibenzothiophene, carbazole derivatives, garnered much attention over time. Scientists interested elucidating more efficient techniques for developing these industrially essential compounds. Dibenzo‐fused can rapidly be synthesised using highly transition metal‐catalysed strategies as well by economic metal‐free reaction conditions. This review includes detailed overview recent significant synthetic techniques, both metal‐free, to produce medicinally important dibenzo‐fused heterocycles.

Language: Английский

A Multicomponent Reaction-Based Platform Opens New Avenues in Aryl Hydrocarbon Receptor Modulation DOI Creative Commons
Pau Nadal Rodríguez,

Frederick Hartung,

Marina Pedrola

et al.

ACS Central Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

A multidisciplinary platform is presented to address aryl hydrocarbon receptor (AhR) modulation. rewired Yonemitsu multicomponent reaction with indole 2-carboxaldehydes and nucleophilic species was designed access a family of 6-substituted indolocarbazoles. The conformational behavior these compounds examined rationalize their axial chirality. In silico docking molecular simulations highlighted key features implicated in binding AhR. Furthermore, the synthesis linkable derivatives allowed direct development conjugated entities. Reporter gene target expression analyses identified novel structures as potent noncytotoxic activating AhR ligands, that can be extended bifunctional molecules. anti-inflammatory properties agonists were assessed interleukin-13 treated keratinocytes. Altogether, synergistic research synthetic computational chemistry integrated biological studies opens avenues toward understanding roles targeted therapeutics.

Language: Английский

Citations

0
Recent advances in the catalytic asymmetric construction of axially chiral azole-based frameworks DOI
Weiwei Luo, Yu Zhang,

Meijun Ming

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(23), P. 6819 - 6849

Published: Jan. 1, 2024

This review highlights recent advances in the atroposelective preparation of axially chiral azole derivatives, emphasizing mechanistic insights and synthetic applications development this class five-membered heterocyclic frameworks.

Language: Английский

Citations

2
Dibenzo‐Fused Heterocycles: A Decade Update on the Syntheses of Carbazole, Dibenzofuran, and Dibenzothiophene DOI
Anjana Sreekumar, Ajil R. Nair,

C. Raksha

et al.

The Chemical Record, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

Abstract Polycyclic heterocycles are the most common and critical structural motifs found in a variety of natural products, medicines, fertilizers, advanced materials. Because their widespread use biologically active compounds material chemistry, functionalised dibenzo heterocyclic compounds, especially dibenzofuran, dibenzothiophene, carbazole derivatives, garnered much attention over time. Scientists interested elucidating more efficient techniques for developing these industrially essential compounds. Dibenzo‐fused can rapidly be synthesised using highly transition metal‐catalysed strategies as well by economic metal‐free reaction conditions. This review includes detailed overview recent significant synthetic techniques, both metal‐free, to produce medicinally important dibenzo‐fused heterocycles.

Language: Английский

Citations

1