Green Synthesis and Catalysis, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 25, 2025
Comprehensive Summary Vicinal all‐carbon quaternary stereocenters are widely present in natural products and bioactive molecules. However, the construction of such motif one step from readily available starting materials remains a significant challenge. Herein, we report phosphine‐catalyzed divergent γ,γ‐ ε,γ‐umpolung domino addition bisoxindoles with allenoates. This method serves as practical tool for concise synthesis series bisoxindole derivatives bearing sterically hindered vicinal under mild reaction conditions. The applicability this novel was demonstrated gram‐scale three known advanced intermediates total syntheses calycanthine, chimonanthine folicanthine.
Language: Английский
Citations
2
Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(10), P. 2762 - 2767
Published: Jan. 1, 2024
A P(NMe2)3-catalyzed [4 + 2] annulation of 2-amino-β-nitrostyrenes and β′-acetoxy allenoates followed by a Zn/AcOH-mediated reduction–hydroamination–isomerization has been developed.
Language: Английский
Citations
9
Chemical Communications, Journal Year: 2024, Volume and Issue: 60(53), P. 6773 - 6776
Published: Jan. 1, 2024
A novel phosphine-mediated α-umpolung/Wittig olefination/cyclization cascade process between o -aminobenzaldehydes and Morita–Baylis–Hillman (MBH) carbonates has been ingeniously developed for the facile synthesis of a broad range 2-vinylindolines.
Language: Английский
Citations
6
Organic Letters, Journal Year: 2024, Volume and Issue: 26(36), P. 7576 - 7583
Published: Sept. 3, 2024
An efficient pyridine-catalyzed chemoselective four-component cascade reaction of aromatic aldehydes, malononitrile/cyanoacetates, Morita-Baylis-Hillman (MBH) carbonates, and alcohols has been established. This one-pot progressed in an unusual with solvent participation via a Knoevenagel condensation/oxa-Michael addition/S
Language: Английский
Citations
2
Organic Letters, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 7, 2024
An unexpected phosphine-catalyzed controllable three-component domino reaction involving [1 + 2 2] annulation and 2]/[3 sequential of 2-arylmethylidene cyanoacetates/malononitriles with Morita-Baylis-Hillman (MBH) carbonates has been developed. A broad range densely functionalized cyclopentanes diquinanes bearing five or four consecutive stereogenic centers, including two all-carbon quaternary stereocenters, were smoothly acquired in moderate to excellent yields under mild conditions from readily available materials. Moreover, this divergent transformation enables the simultaneous generation three new C-C bonds one carbocyclic rings only step.
Language: Английский
Citations
2
Organic Letters, Journal Year: 2024, Volume and Issue: 26(43), P. 9203 - 9209
Published: Oct. 21, 2024
Controlling the selectivity of reactions is a significantly attractive strategy in synthetic organic chemistry. Herein, an efficient base-controlled chemodivergent domino reaction between o-aminochalcones and γ-bromocrotonates has been developed. A series cis-2,3-disubstituted indolines cyclopropane-fused tetrahydroquinolines were obtained via two pathways with broad substrate scope moderate to excellent yields under transition-metal-free conditions. It noteworthy that could be used as C1 or C2 synthons by modulating base; particular, both nucleophiles electrophiles generate cyclopropanes for first time.
Language: Английский
Citations
1
Synthetic Communications, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12
Published: Sept. 13, 2024
Language: Английский
Citations
0
Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(23), P. 4805 - 4834
Published: Oct. 21, 2024
Abstract The ever‐increasing prevalence of diseases and inadequate resources on Earth are threats to society. Biomass is an abundant resource, bioactive compounds produced from biomass environmentally benign in contrast conventional chemical synthesis methods, which frequently depend non‐renewable resources. In addition, the functionalized monomers allow atom economical molecules. This review aims provide insight into molecules lignocellulose‐derived platform chemicals. Existing methodology catalytic systems summarized for targeted cellulose, hemicellulose, lignin‐derived biological activities obtained biomass, such as antioxidant, anti‐inflammatory, anticancer properties, discussed.
Language: Английский
Citations
0
RSC Advances, Journal Year: 2024, Volume and Issue: 14(24), P. 17178 - 17183
Published: Jan. 1, 2024
Cyclic N-sulfonyl aldimines are well-known aza-[2C]-synthons for various [2 + n] annulation reactions. Herein we describe a novel base mediated 1] and regioselective aziridine ring-opening reaction cascade, which provides an efficient distinct synthetic strategy from readily available cyclic α-carbonyl sulfonium salts leading to β-amino ketone derivatives through the corresponding fused tri-substituted aziridines. This one-pot, two-step process involves formation of C-C C-N bonds subsequent cleavage bond. The features developed include use mild conditions, broad substrate scope, excellent yields. utility this approach was demonstrated by gram-scale operation further product derivatizations.
Language: Английский
Citations
0
Green Synthesis and Catalysis, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
0