Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(19)
Published: March 19, 2024
Abstract There is a substantially ascending demand for nonantibiotic strategies to overcome the resistance of bacterial infections. Here, discovery distinctive antibacterial structure reported. The novel nanoparticle strategy proposed appreciable bacteria killing by smart design delayed addition crosslinkers into reaction mixture. [2‐(methacryloyloxy)ethyl]trimethylammonium chloride solution (MTCl), water‐soluble ionic liquid (IL), has narrow‐size material distribution, good whiteness, and high weather resistance. quaternary ammonium salt utilized efficiently permeate cell membranes through electrostatic interaction, accordingly, boasting beneficiary properties. More importantly, it allows attach nanomaterials easily, especially double‐shelled nanosphere. In light introduction 9‐amino(9‐deoxy)ep‐quinine (QNNH 2 ) on its inner shell, blocks nucleic acid glucose metabolism in bacteria, which betterment activity compared other nanomaterials. This physical/chemical/biological triple process eliminates need traditional antibiotics, fabrication properties described here provide insights based chemical physical effects.
Language: Английский