Indoloquinoline Alkaloids as Antimalarials: Advances, Challenges, and Opportunities DOI Creative Commons
Prakash T. Parvatkar,

Khaly Diagne,

Yingzhao Zhao

et al.

ChemMedChem, Journal Year: 2024, Volume and Issue: unknown

Published: June 6, 2024

Abstract Malaria infections affect almost half of the world‘s population, with over 200 million cases reported annually. Cryptolepis sanguinolenta , a plant native to West Africa, has long been used across various regions Africa for malaria treatment. Chemical analysis revealed that is abundant in indoloquinolines, which have shown possess antimalarial properties. Cryptolepine, neocryptolepine, and isocryptolepine are well‐studied indoloquinoline alkaloids known their potent activity. However, structural rigidity associated cellular toxicity major drawbacks preclinical development. This review focuses on potential (cryptolepine, isocryptolepine) as scaffolds drug discovery. The article delves into effects vitro vivo, well proposed mechanisms action structure‐activity relationship studies. Several studies aim improve these leads by reducing cytotoxicity while preserving or enhancing activity gaining insights action. These investigations highlight indoloquinolines scaffold developing new drugs.

Language: Английский

Nitro Substrates in Reductive Electrosynthesis: A Review DOI Creative Commons
Sebastián O. Simonetti, Sebastian B. Beil, Siegfried R. Waldvogel

et al.

ACS electrochemistry., Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Language: Английский

Citations

0
Indoloquinoline Alkaloids as Antimalarials: Advances, Challenges, and Opportunities DOI Creative Commons
Prakash T. Parvatkar,

Khaly Diagne,

Yingzhao Zhao

et al.

ChemMedChem, Journal Year: 2024, Volume and Issue: unknown

Published: June 6, 2024

Abstract Malaria infections affect almost half of the world‘s population, with over 200 million cases reported annually. Cryptolepis sanguinolenta , a plant native to West Africa, has long been used across various regions Africa for malaria treatment. Chemical analysis revealed that is abundant in indoloquinolines, which have shown possess antimalarial properties. Cryptolepine, neocryptolepine, and isocryptolepine are well‐studied indoloquinoline alkaloids known their potent activity. However, structural rigidity associated cellular toxicity major drawbacks preclinical development. This review focuses on potential (cryptolepine, isocryptolepine) as scaffolds drug discovery. The article delves into effects vitro vivo, well proposed mechanisms action structure‐activity relationship studies. Several studies aim improve these leads by reducing cytotoxicity while preserving or enhancing activity gaining insights action. These investigations highlight indoloquinolines scaffold developing new drugs.

Language: Английский

Citations

0