Chemical diversity and biological activities of secondary metabolites produced by Pleosporales sp. DOI Open Access
Mamdouh Nabil Samy

Vietnam Journal of Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 13, 2024

Abstract Fungi are one of the richest sources bioactive metabolites, which can be used to produce innovative therapeutic agents. Pleosporales sp. including epiphytic, endophytic, or parasitic species yield diverse secondary metabolites widely spread throughout many ecosystems. These classified into polyketides, alkaloids, sesquiterpenoids, diterpenoids, steroids, and others depending on their unique structural characteristics. Secondary produced by displayed outstanding biological activities such as cytotoxic, antibacterial, antifungal, anti‐inflammatory properties. The goal this review was compile most recent, comprehensive literature data metabolite classes sp., backed its various bioactivity data, a scientific record for upcoming drug discovery endeavors.

Language: Английский

Antibacterial Activity and AbFtsZ Binding Properties of Fungal Metabolites Isolated from Mexican Mangroves DOI Creative Commons
Karol Carrillo-Jaimes, Carlos A. Fajardo‐Hernández, Fernanda Hernández-Sedano

et al.

Revista Brasileira de Farmacognosia, Journal Year: 2024, Volume and Issue: 34(3), P. 564 - 576

Published: Jan. 2, 2024

Abstract Antimicrobial resistance is emerging as a global health challenge that requires immediate and concerted attention. Accordingly, the WHO has issued alerts urging to continue developing antibiotics with novel mechanisms of action toward clinically important pathogens, including Acinetobacter baumannii . In this context, fungi have played crucial role in discovery development antibiotics. Therefore, work, three fungal strains were prioritized based on their metabolic profiles antibacterial activity against pan-resistant isolate A. , identify potential antibiotic molecules. Chemical investigation selected (mangrove endophytes) led isolation asperazine ( 1 ), aurasperone B 2 F 3 TMC-256A1 4 fonsecin 5 dianhydroaurasperone C 6 A 7 pyrophen 8 penicillide 9 ). Moreover, an vitro assay detect ligands filamentous temperature-sensitive mutant Z enzyme Ab FtsZ), GTPase plays central bacterial division, was developed correlate properties isolated molecules mechanism action. Compounds – inhibited growth Interestingly, compounds interacted FtsZ 1-412 increasing its activity. Conversely, compound exhibited outstanding ability act inhibitor both enzymatic strain under study. Graphical

Language: Английский

Citations

6
Electronic nose technology for the detection of ergot alkaloid in soft wheat and identification of the relevant volatile compounds by solid phase microextraction/gas chromatography-high resolution Orbitrap-mass spectrometry coupled to chemometrics DOI Creative Commons
Maurizio Piergiovanni, Chiara Giliberti,

Cristian Maffezzoni

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144455 - 144455

Published: April 1, 2025

Language: Английский

Citations

0
New piperazine derivatives helvamides B–C from the marine-derived fungus Penicillium velutinum ZK-14 uncovered by OSMAC (One Strain Many Compounds) strategy DOI Creative Commons
Gleb V. Borkunov, Elena V. Leshchenko,

Dmitrii V. Berdyshev

et al.

Natural Products and Bioprospecting, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 21, 2024

Abstract Four extracts of the marine-derived fungus Penicillium velutinum J.F.H. Beyma were obtained via metal ions stress conditions based on OSMAC (One Strain Many Compounds) strategy. Using a combination modern approaches such as LC/UV, LC/MS and bioactivity data analysis, well in silico calculations, influence factors to change metabolite profiles analyzed. From ethyl acetate extract P. isolated two new piperazine derivatives helvamides B ( 1 ) C 2 together with known saroclazin A 3 (4 S ,5 R ,7 )-4,11-dihydroxy-guaia-1(2),9(10)-dien 4 ). Their structures established spectroscopic methods. The absolute configuration helvamide was determined by X-ray analysis time-dependent density functional theory (TD-DFT) calculations electronic circular dichroism (ECD) spectra. cytotoxic activity compounds against human prostate cancer PC-3 embryonic kidney HEK-293 cells growth inhibition yeast-like fungi Candida albicans assayed. Graphical

Language: Английский

Citations

2
Synthesis of 1,2,4,5-Tetra-Substituted Benzenes via Copper-Catalyzed Dimerization of γ,δ-Unsaturated ketones DOI

Kai-Xian Ma,

Chuan‐Ming Hong,

Jiang-Min Yan

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(60), P. 7753 - 7756

Published: Jan. 1, 2024

An efficient cyclization for the synthesis of 1,2,4,5-tetra-substituted benzenes

Language: Английский

Citations

0
Digirseophene A promotes recovery in injured developing cerebellum via AMPK/AKT/GSK3β pathway-mediated neural stem cell proliferation DOI Creative Commons

X.-C. Tang,

Yuting Huang,

Wenying Fu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 117046 - 117046

Published: July 8, 2024

Neural stem cells (NSCs) exhibit a remarkable capacity for self-renewal and have the potential to differentiate into various neural lineage cells, which makes them pivotal in management of neurological disorders. Harnessing inherent endogenous NSCs enhancing nerve repair regeneration represents an optimal approach addressing diseases nervous system. In this study, we explored novel benzophenone derivative named Digirseophene A (DGA), was isolated from endophytic fungus Corydalis tomentella. Previous experiments extensively identified characterized DGA, revealing its unique properties. Our findings demonstrate capability DGA stimulate cell proliferation, both vitro vivo. Furthermore, established model radiation-induced cerebellar injury assess effects on distribution different subpopulations within damaged cerebellum, thereby suggesting beneficial role repair. addition, our observations primary revealed that significantly increased cellular oxygen consumption, indicating energy metabolic demands. By utilizing pathway inhibitors combination with successfully demonstrated ability counteract suppressive impacts AMPK GSK3β NSC proliferation. Collectively, research results strongly suggest as innovative compound, exerts activating promoting through regulation AMPK/AKT/GSK3β pathway.

Language: Английский

Citations

0
A new tetrahydroxybenzophenone from a marine-associated fungus of penicillium sp. and its potential antibacterial activity DOI
Ruifeng Huang,

Shuaiqi Ma,

Jiale Wu

et al.

Natural Product Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 8

Published: Sept. 16, 2024

species are renowned for their ability to produce a wide range of secondary metabolites with medicinal properties. In this study, compounds

Language: Английский

Citations

0
Revealing the backbone structures of land-based fulvic acids derived from river and soil through n-butylsilane reduction DOI
Haojie Hu, Chen He,

Di Zhu

et al.

Analytical and Bioanalytical Chemistry, Journal Year: 2024, Volume and Issue: 416(29), P. 6919 - 6929

Published: Oct. 10, 2024

Language: Английский

Citations

0
Comparing the linear and non-linear optical properties of keto-enol forms of N-alkyl, N-aryl, and O-alkyl substituted 2-Hydroxybenzophenone DOI

Zeba Khan,

Nagaiyan Sekar

Computational and Theoretical Chemistry, Journal Year: 2024, Volume and Issue: 1242, P. 114980 - 114980

Published: Nov. 6, 2024

Language: Английский

Citations

0
Chemical diversity and biological activities of secondary metabolites produced by Pleosporales sp. DOI Open Access
Mamdouh Nabil Samy

Vietnam Journal of Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 13, 2024

Abstract Fungi are one of the richest sources bioactive metabolites, which can be used to produce innovative therapeutic agents. Pleosporales sp. including epiphytic, endophytic, or parasitic species yield diverse secondary metabolites widely spread throughout many ecosystems. These classified into polyketides, alkaloids, sesquiterpenoids, diterpenoids, steroids, and others depending on their unique structural characteristics. Secondary produced by displayed outstanding biological activities such as cytotoxic, antibacterial, antifungal, anti‐inflammatory properties. The goal this review was compile most recent, comprehensive literature data metabolite classes sp., backed its various bioactivity data, a scientific record for upcoming drug discovery endeavors.

Language: Английский

Citations

0