Molbank,
Journal Year:
2024,
Volume and Issue:
2024(4), P. M1927 - M1927
Published: Nov. 28, 2024
The
ligandless
palladium-catalyzed
Heck
reaction
of
4-ethenyl-3-methoxy-1-phenyl-1H-pyrazole
and
2-([1,1′-biphenyl]-4-yl)-5-bromo-3,3-dimethyl-3H-indole
gave
the
previously
unreported
2-([1,1′-biphenyl]-4-yl)-5-[(E)-2-(3-methoxy-1-phenyl-1H-pyrazol-4-yl)ethenyl]-3,3-dimethyl-3H-indole
in
45%
yield.
compound
was
characterized
using
NMR,
FT-IR
spectroscopy,
HRMS
data.
optical
properties
were
investigated
tetrahydrofuran
by
UV-Vis
fluorescence
spectroscopy.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(23)
Published: March 19, 2024
The
selective
oxidative
coupling
of
phenol
derivatives,
involving
carbon-carbon
(C-C)
and
carbon-oxygen
(C-O)
bond
formation,
has
emerged
as
a
critical
approach
in
the
synthesis
natural
products.
However,
achieving
precise
control
over
selectivity
reactions
unsubstituted
phenols
utilizing
solar
light
driving
force
remains
big
challenge.
In
this
study,
we
report
series
porous
Cs
Results in Chemistry,
Journal Year:
2023,
Volume and Issue:
6, P. 101135 - 101135
Published: Sept. 24, 2023
The
scaffold-based
drug
design
has
been
widely
used
in
new
discovery.
Biphenyl
and
its
analog
scaffold
are
found
many
drugs
naturally
occurring
compounds.
To
date
an
array
of
synthetic
methodologies
have
introduced
to
access
biphenyl
analogs
with
good
yield.
scaffolds
shown
wide
range
biological
activities
such
as
anti-inflammatory,
antihypertensive,
treatment
CNS
disorders,
anti-cancer,
anti-HIV,
etc.
Also,
the
importance
atropisomers
is
discussed.
This
review
aims
highlight
evidence
motif
a
privileged
various
natural
products
anticancer
agents.
Applied Organometallic Chemistry,
Journal Year:
2025,
Volume and Issue:
39(2)
Published: Jan. 21, 2025
ABSTRACT
The
United
Nations
sustainable
development
goals
9
and
12
discuss
about
adoption
of
green
chemistry
concept
for
manufacturing
pharmaceuticals
chemicals.
Water
is
universally
accepted
as
a
solvent
organic
reactions,
solvent‐free
reactions
are
considered
green,
methods
synthesis
heterocyclic
compounds.
Pd/C
heterogeneous,
recyclable
catalyst
has
been
used
several
cross‐coupling
reactions.
A
ligand‐free
Pd/C‐catalyzed
homocoupling
reaction
haloarenes
in
water
reported.
condition
mild
(reaction
temp.
40°C),
the
desired
products
were
isolated
moderate
to
good
yield
(56%–81%).
Activation
phase
transfer
under
microwave
irradiation
reduced
loading
time
(from
24
h
30
min).
major
advantages
this
method
over
existing
(i)
reaction,
(ii)
lower
loading,
(iii)
use
solvent.
This
along
with
continuous‐flow
bromination,
amine
deprotection
successfully
applied
antiviral
drug
daclatasvir.
Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(42), P. 8573 - 8578
Published: Jan. 1, 2023
A
highly
effective
strategy
for
the
synthesis
of
meta-arylphenol
derivatives
through
selective
rearrangement
4-alkyl-4-aryl-2,5-cyclohexadienones
under
metal-free
conditions
was
developed,
in
which
acid-promoted
[1,2]-migration
aryl
group
at
C-4
occurred
exclusively
when
alkyl
a
methyl
group.
Treatment
4-methyl-4-aryl-2,5-cyclohexadienones
with
37%
HCl
Ac2O
room
temperature
provided
polysubstituted
meta-arylphenyl
acetates
75-94%
yields.
The
application
this
protocol
polycyclic
aromatic
compounds
also
described.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(30)
Published: March 11, 2024
Abstract
A
novel
class
of
diazonium
salts
is
introduced
for
the
photochemical
aryl‐aryl
coupling
to
produce
(substituted)
biphenyls.
As
common
tetrafluoroborate
fail,
soluble
and
safe
aryl
trifluoroacetates
are
applied.
In
this
mild
synthesis
route
no
catalysts
required
generate
an
aryl‐radical
by
irradiation
with
UV‐A
light
(365
nm).
This
reactive
species
undergoes
direct
C−H
arylation
at
arene,
forming
product
in
reasonable
reaction
times.
With
implementation
a
continuous
flow
setup
capillary
photoreactor
13
different
biphenyl
derivatives
successfully
synthesized.
By
integrating
inline
19
F‐NMR
benchtop
spectrometer,
samples
reliably
quantified
as
fluorine‐substituents
act
probe.
Here,
real‐time
NMR
spectroscopy
perfect
tool
monitor
continuously
operated
system,
which
produces
fine
chemicals
industrial
relevance
even
multigram
scale.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(23)
Published: March 19, 2024
Abstract
The
selective
oxidative
coupling
of
phenol
derivatives,
involving
carbon‐carbon
(C−C)
and
carbon‐oxygen
(C−O)
bond
formation,
has
emerged
as
a
critical
approach
in
the
synthesis
natural
products.
However,
achieving
precise
control
over
selectivity
reactions
unsubstituted
phenols
utilizing
solar
light
driving
force
remains
big
challenge.
In
this
study,
we
report
series
porous
Cs
3
Bi
2
X
9
(X=Cl,
Br,
I)
photocatalysts
with
tailored
band
gaps
compositions
engineered
for
efficient
solar‐light‐driven
coupling.
Notably,
p‐Cs
Br
exhibited
about
73
%
C−C
coupling,
displaying
high
formation
rate
47.3
μmol
g
cat
−1
h
under
radiation.
Furthermore,
enables
site‐selectivity
derivatives
on
,
enhancing
distinctive
structure
appropriate
band‐edge
positions
facilitated
charge
separation,
surface
interaction/activation
phenolic
hydroxyl
groups,
resulting
kinetically
preferred
C−O
bond.
Mechanistic
insights
into
reaction
pathway,
supported
by
comprehensive
experiments,
unveiled
crucial
role
interfacial
transfers
Lewis
acid
sites
stabilizing
intermediates,
thereby
directing
regioselectivity
diradical
couplings
unsymmetrical
biphenols.
An
additive-free
manganese-catalyzed
isomerization
of
terminal
alkenes
to
internal
is
described.
This
reaction
atom
economic,
implementing
an
inexpensive,
non-precious
metal
catalyst.
The
most
efficient
catalyst
the
borohydride
complex
cis-[Mn(dippe)(CO)2(κ2-BH4)].
operates
at
room
temperature
with
a
loading
2.5
mol
%.
A
variety
are
effectively
and
selectively
transformed
respective
E-alkenes.
Preliminary
results
show
chain
walking
elevated
temperature.
Mechanistic
studies
were
carried
out
including
stochiometric
reactions
in
situ
NMR
analysis.
These
experiments
flanked
by
computational
studies.
Based
on
these,
catalytic
process
initiated
liberation
“BH3”
as
hydroborated
alkene.
double
bond
insertion
into
M–H
species
leading
alkyl
intermediate,
followed
β-hydride
elimination
opposite
position
afford
product.
