Synlett,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 22, 2024
Abstract
We
report
a
catalyst-free
intermolecular
hydride-transfer
reaction
to
synthesize
N-benzylindolines
under
microwave
heating
in
the
absence
of
solvent.
The
reactions
are
performed
by
taking
indoline
(two
equivalents)
with
aryl
aldehydes,
which
give
good
yields
products.
Tetrahydroisoquinoline
can
also
be
used
place
excellent
expected
A
mechanism
has
been
proposed.
antioxidant
properties
all
were
tested
and
compared
that
ascorbic
acid,
showing
some
them
powerful
antioxidants.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(9), P. 1986 - 1986
Published: April 26, 2024
Microwave-assisted
organic
synthesis
(MAOS)
has
emerged
as
a
transformative
technique
in
chemistry,
significantly
enhancing
the
speed,
efficiency,
and
selectivity
of
chemical
reactions.
In
our
research,
we
have
employed
microwave
irradiation
to
expedite
quinazolinones,
using
water
an
eco-friendly
solvent
thereby
adhering
principles
green
chemistry.
Notably,
purification
product
was
achieved
without
need
for
column
chromatography,
thus
streamlining
process.
A
key
innovation
approach
is
aldehyde
bisulfite
adducts
(Bertagnini's
salts)
solid
surrogates
aldehydes.
Bertagnini's
salts
offer
several
advantages
over
free
aldehydes,
including
enhanced
stability,
easier
purification,
improved
reactivity.
Green
metrics
Eco-Scale
score
calculations
confirmed
sustainability
this
approach,
indicating
reduction
waste
generation
outcomes.
This
methodology
facilitates
diverse
array
compounds,
offering
substantial
contributions
field,
with
potential
widespread
applications
pharmaceutical
research
beyond.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(33)
Published: Aug. 30, 2024
Abstract
3‐methyl‐4‐(hetero)arylmethylidene
isoxazole‐5(4H)‐one
derivatives
(4a‐r)
were
synthesized
by
the
multi‐component
reactions.
The
reactions
(MCRs)
of
hydroxylamine
hydrochloride,
ethyl
acetoacetate
and
aromatic/
heteroaromatic
aldehyde
catalyzed
novel
Glutamic
acid
(Glu)
as
a
biodegradable
eco‐friendly
organocatalyst
in
ethanol
on
oil
bath
stirring
at
60
°C.
final
product
homogeneity
was
examined
various
spectroscopic
techniques.
In
this
work
prepared
compounds
4
q
r
are
derivatives.
molecular
dynamics
total
energy
gap
calculated
using
DFT/B3LYP/6–31G
(dp)
method.
selected
(
l
–
)
screened
against
vitro
MCF‐7
breast
cancer
cell
line
MTT
assay,
o
displayed
very
good
activity
with
IC
50
6.57±2.31
,
21.93±1.34
compared
to
doxorubicin
3.69±0.17
).
Molecular
docking
studies
performed
evaluate
interaction
PDB
id:
1
M17
led
molecules
MCF‐7.
Later,
underwent
200
ns
simulation
within
physiological
conditions,
outcomes
showed
that
during
simulation,
ligand
stayed
same
form.
Further,
drug
like
computed
swissADME,
obeyed
rule
Lipinski's.
Furthermore,
tested
for
electrochemical
behavior
cyclic
voltammetry,
compound
strong
oxidation
reduction
potential,
thus
these
can
present
better
antioxidant
properties.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(23)
Published: June 18, 2024
Abstract
The
fluorinated
5‐membered
N
‐containing
heterocyclic
compounds
have
wide
utility
in
varied
fields.
importance
of
these
has
encouraged
researchers
to
explore
environment‐friendly
synthetic
techniques
for
their
synthesis.
In
this
context,
microwave‐assisted
synthesis
proved
beneficial
the
‐heterocycles
an
environmentally
benign
and
energy‐efficient
manner.
Compared
conventional
heating,
it
offers
several
advantages,
including
quick
short
reaction
times,
higher
yields,
fewer
side
reactions.
This
article
highlights
fluorination
‐heterocyclic
along
with
using
starting
materials.
Current Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
28(20), P. 1605 - 1612
Published: July 10, 2024
:
A
modified
solid-liquid
halex
reaction
was
developed
in
the
presence
of
a
robust
phase
transfer
catalyst
under
microwave
conditions.
fast,
mild,
and
practical
microwave-
assisted
synthesis
2,3-difluoro-5-chloropyridine
3
starting
from
2,3,5-
trichlorpyridine
1
spray-dried
KF
polar
aprotic
solvent
developed.
The
addition
Tetrakis
(piperidino)
phosphonium
chloride
as
studied
irritation
(450W)
increased
yield
significantly
reduced
time
contrast
to
conventional
heating
procedure.
highest
rate
observed
at
5
wt%
salt
2,3,5-trichloropyridine
1.
