The Current Landscape of 1,2,3‐triazole Hybrids With Anticancer Therapeutic Potential: Part II

Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(4)

Published: April 1, 2025

Chemotherapy has been identified as a validated and critically important strategy for the treatment of cancer, but multidrug resistance serious side effects remain grand challenges effective cancer therapy. This highlights urgent need development alternative chemical entities that can modulate more than one biological target with high specificity multitargeted mechanism action in disease progression pathway. 1,2,3-Triazole hybrids have potential to act on dual/multiple targets cells simultaneously possess potent broad-spectrum activity against various cancers, including drug-resistant forms. Thus, 1,2,3-triazole are valuable scaffolds eradication cancer. review provides comprehensive overview evolving landscape their vitro vivo anticancer potential, structure-activity relationships well mechanisms also discussed, covering articles published from 2021 onward.

Language: Английский

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Access to Bicyclo[3.1.0]hexane and Cyclopenta[c]pyrazole Scaffolds via Solvent-Directed Divergent Reactivity of 5-Iodotriazoles

Organic Letters, Journal Year: 2024, Volume and Issue: 26(45), P. 9625 - 9630

Published: Nov. 6, 2024

Divergent access to bicyclo[3.1.0]hexane and cyclopenta[c]pyrazole scaffolds bearing azole azine units has been developed. The approach involves intramolecular cyclization of 5-iodo-1,2,3-triazoles acting as stable diazoimine precursors with concomitant noncatalytic (3 + 2)-cycloaddition. choice solvent allows control the outcome cascade transformation. developed procedure is simple cost-efficient allowed important heterocycles be obtained in one-pot various functional groups.

Language: Английский

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Five-membered ring systems: With more than 1 N atom

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 211 - 257

Published: Jan. 1, 2024

Language: Английский

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