Insight on development of oxazole and imidazole derivatives as COX inhibitors with anti-inflammatory effects DOI

Seham A. Rayan,

Riham F. George,

Mona F. Said

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140148 - 140148

Published: Sept. 1, 2024

Language: Английский

Recent advancements of pyrimidine chemistry thriving deeper into drug discovery DOI
Glanish Jude Martis,

O Sneha,

Rajkumar Bhat D

et al.

Synthetic Communications, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 29

Published: April 3, 2025

Language: Английский

Citations

0
Access to Methylidene-Azaspiro[4.5]decatrienones via Radical-Promoted Domino Thio-Functionalization/Dearomative Ipso-Annulation DOI
Chada Raji Reddy,

Puthiya Purayil Vinaya,

Ejjirotu Srinivasu

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

An unprecedented approach involving radical-mediated sulfonylation/dearomative ipso-annulation of N-(methyl-2-phenylacetate)propiolamides using arylsulfonyl radical, generated from aryl diazonium salt in the presence DABSO, is developed. This strategy provides uniquely substituted 3-sulfonyl azaspiro[4.5]decatrienones good yields. The developed has also been extended fruitfully to 3-thiocyano aza-spirocycles through domino thiocyanation/dearomative ipso-annulation.

Language: Английский

Citations

0
Synthesis and Anti‐Inflammatory Activity of Spiropyrimido[4,5‐d]pyrimidine Derivatives DOI

Emna Maalej,

Olfa Kallech Ziri,

Wiem Ayadi

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(15)

Published: April 1, 2025

Abstract Herein, we describe the high yielding synthesis of spiropyrimido[4,5‐ d ]pyrimidines by Friedländer‐type reaction substituted 4‐aminopyrimidine‐5‐carbonitriles with cyclohexanone, using sodium ethoxide as catalyst. The biological activity new compounds anti‐inflammatory agents was evaluated and to predict their pharmacological properties a comprehensive in silico analysis conducted. Among tested compound, three exhibited potent lipoxygenase inhibitory comparing very well reference octyl gallate.

Language: Английский

Citations

0
Pyrimidines: A New Versatile Molecule in the Drug Development Field, Scope, and Future Aspects DOI Creative Commons
Katharigatta N. Venugopala, Vinuta Kamat

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1258 - 1258

Published: Sept. 24, 2024

Pyrimidine is a moiety that occurs in living organisms and has variety of significant biological properties pharmacology. Due to the easy handling synthesis, easily available precursor, less duration for reaction, not many technical skills are needed. All these factors attract chemists focus more on pyrimidines. Apart from synthesis applications pyrimidines, medicinal have gathered explore pyrimidine scaffolds due their interesting targeting various binding sites. This review delves into diverse activities compounds derived during year 2024. We attempted growing significance derivatives provide new path designing potent molecules.

Language: Английский

Citations

2
Path of Pyrazoles from Synthetic Factors to Anti-inflammatory Potential: A Review DOI Open Access
Ketan Vashisht, Pooja Sethi, Anshul Bansal

et al.

Asian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 36(6), P. 1217 - 1231

Published: May 31, 2024

Pyrazoles, a class of heterocyclic compounds, have garnered considerable attention in drug development due to their intriguing properties, particularly those containing pyrazole moiety. Pyrazole, pivotal chemical the creation potent bioactive agents, encompasses five members. The discovery certain compounds exhibiting robust biological activities has spurred interest this field inquiry. Heterocyclic incorporating nitrogen and its derivatives historically served as crucial sources medicinal compounds. Given that group constitutes vast reservoir organic molecules, significance both theoretical applied chemistry grown significantly. Extensive literature indicates researchers employed diverse synthetic strategies recent years produce substituted with promising potential anti-HIV, anti-inflammatory, antitumor antimicrobial agents. Inflammation, multifaceted response essential for body’s defense mechanisms, can also contribute various pathological conditions when dysregulated. Understanding underlying molecular mechanisms offers foundation targeted interventions against inflammatory disorders. These insights fuel ongoing endeavors discover effective innovative anti-inflammatory agents therapeutic applications. This review delves into synthesis characterization derivatives, emphasizing structural modifications influencing efficacy. provided herein are invaluable rational design novel Furthermore, concludes discussion on future perspectives, underscoring imperative further research optimize

Language: Английский

Citations

1
Synthesis, structural, spectroscopic investigation, Hirshfeld surface analysis and DFT calculation of a new spiro compound including 4-nitroaniline moiety DOI
Wu-Lan Zeng, Dick K. P. Yue, Xia Wang

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1322, P. 140371 - 140371

Published: Oct. 13, 2024

Language: Английский

Citations

1
Insight on development of oxazole and imidazole derivatives as COX inhibitors with anti-inflammatory effects DOI

Seham A. Rayan,

Riham F. George,

Mona F. Said

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140148 - 140148

Published: Sept. 1, 2024

Language: Английский

Citations

0