Synthesis, cytotoxicity, apoptosis-inducing activity and molecular docking studies of novel isatin–podophyllotoxin hybrids

RSC Advances, Journal Year: 2025, Volume and Issue: 15(4), P. 2825 - 2839

Published: Jan. 1, 2025

Compound 7f exhibited cytotoxicity to A549 cells, inducing apoptosis and cell cycle arrest in a dose-dependent manner. It also interacted with ATP binding sites of CDK2/cyclin A CDK5/p25, activated procaspase 6 through stable zinc chelation.

Language: Английский

Novel zerumbone-secondary amide hybrids: ultrasonic synthesis, cytotoxic evaluation, molecular docking and in silico ADMET studies

RSC Advances, Journal Year: 2025, Volume and Issue: 15(12), P. 8986 - 8998

Published: Jan. 1, 2025

Zerumbone, along with its various derivatives and structurally related compounds, has attracted significant scientific interest due to broad-spectrum pharmacological properties, particularly anticancer potential.

Language: Английский

Improved synthesis, molecular modeling and anti-inflammatory activity of new fluorinated dihydrofurano-naphthoquinone compounds

Bioorganic & Medicinal Chemistry Letters, Journal Year: 2024, Volume and Issue: 104, P. 129714 - 129714

Published: March 23, 2024

Language: Английский