Chiral Phosphoric Acid-Catalyzed Enantioselective Synthesis of Biphenyl-Bridged ɛ-Sultams via Friedel-Crafts Reactions of Cyclic N-Sulfonylimines with Indolizines

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(17), P. 4829 - 4835

Published: Jan. 1, 2024

An asymmetric aza-Friedel–Crafts arylation of biphenyl-bridged seven-membered cyclic N -sulfonylimines with indolizines via chiral phosphoric acid is realized, affording indolizine modified ε-sultams up to 99% yield and ee.

Language: Английский

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Copper-Catalyzed Asymmetric 1,2-Arylboration of Enamines: Ac-cess to Chiral Borate-Containing 3,3’-Disubstituted Isoindolinones

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(30), P. 6085 - 6089

Published: Jan. 1, 2024

An enantioselective Cu-catalyzed 1,2-arylboration reaction of N -( o -iodobenzoyl)enamines with bis(pinacolato)diboron (B 2 pin ) is developed to access chiral borate-containing 3,3′-disubstituted isoindolinones.

Language: Английский

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Rh(III)-Catalyzed Aminoalkylation of Alkenes with Diazo Compounds toward Functionalized Isoindolinones

Chinese Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 44(11), P. 3505 - 3505

Published: Jan. 1, 2024

Language: Английский

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Synthesis of 3-Propargyl Isoindolinones by Pd/Cu-Catalyzed Enantioselective Heck/Sonogashira Reaction of Enamides

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

An enantioselective Pd/Cu-catalyzed sequential Heck/Sonogashira reaction of electron-rich enamides is reported, providing various 3-propargyl isoindolinone derivatives bearing quaternary stereogenic centers in good yield and enantioselectivity.

Language: Английский

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