Environmental Implications and Nanotechnological Advances in Octocrylene-Enriched Sunscreen Formulations: A Comprehensive Review

Chemosphere, Journal Year: 2024, Volume and Issue: 358, P. 142235 - 142235

Published: May 3, 2024

Language: Английский

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Impressive merits of Nanocellulose driving sustainable beauty

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 353, P. 123270 - 123270

Published: Jan. 14, 2025

Language: Английский

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Preclinical Toxicological Assessment of 2‐(Benzoxazol‐2‐yl)[(2‐hydroxynaphthyl)diazenyl]phenol Derivatives for Blue Light and UV Radiation Photoprotection Applications

Journal of Applied Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

ABSTRACT The widespread use of electronic devices has led to increased blue light exposure, highlighting the need for effective radiation blockers with protection. Two synthetic 2‐(2′‐hydroxyphenyl)benzoxazole derivatives named azo‐4′‐benzoxazole and azo‐5′‐benzoxazole have shown an unprecedented absorption capacity but had not been subjected a safety evaluation. This study aimed evaluate cytotoxic, genotoxic, mutagenic activities these compounds. cytotoxic genotoxic were evaluated using MTT assay comet in L929 fibroblast cells. Salmonella /microsome micronucleus test performed detect gene chromosomal mutations. IC 50 was 87.9 μg/mL 79.5 azo‐5′‐benzoxazole. In assay, compound induced frameshift mutations TA97a strain presence metabolic activation (S9 mix), while did show all five strains tested. showed effects cells that probably associated cleavage azo‐5′ into its analogs 2‐(4′‐amino‐2′‐hydroxyphenyl)benzoxazole 2‐amino‐1‐naphthol. conclusion, azo‐substituted group at 5′ position phenyl ring appears greater toxicological risks than substituents 4′ 2‐(phenyl)benzoxazole. findings warrant further preclinical studies ensure compounds as filters.

Language: Английский

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Hydroxyapatite coating on ZnO nanoparticles for ultraviolet filter agents

Surface Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

This experimental work aimed to investigate the effects of hydroxyapatite (HAp) coating on zinc oxide (ZnO) nanoparticles and extent which HAp improves protective efficacy ZnO-based sunscreen against UV radiation. First, HAp-coated ZnO were synthesized characterized. Afterwards, they mixed into a basic lotion. Precipitation spray methods applied in synthesis process nanoparticles, then continued with series characterizations using XRF, XRD, UV-vis DRS, SEM-EDS. The results show that an surfaces can make this nanomaterial's optical band gap wider. Also, it makes less capable both absorbing light performing photocatalytic reactions. Furthermore, layer effectively increases radiation reflectance sunscreens. Therefore, is reasonable assume will improve inorganic protection

Language: Английский

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Assessing the exposure to the UV filter DHHB in urine samples from the German Environmental Specimen Bank (2000–2021): Evaluating the impact of a potential impurity of di-n-hexyl phthalate in DHHB

International Journal of Hygiene and Environmental Health, Journal Year: 2025, Volume and Issue: 266, P. 114565 - 114565

Published: March 21, 2025

Language: Английский

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Counteracting Skin Aging In Vitro by Phytochemicals

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(7)

Published: April 1, 2025

ABSTRACT The skin is the most extensive organ in human body. Photo exposure to ultraviolet (UV) rays causes several damages cells, including premature aging, onset of possible DNA mutations, and risk developing cancers, melanoma. Protecting from damaging effects sun through application creams filters important prevent irreversible damages. Several natural extracts biomolecules with antioxidant activity are widely used production dietary supplements or topical products, for prevention treatment affections. Within this context, we pre‐treated fibroblasts (HFF1), skin‐isolated stem cells (SSCs) keratinocytes (HaCaT) two containing a specific solar protection factor (SPF) 72 h then exposed UV light. Gene expression analysis was performed key cell cycle regulators (p16, p19, p21, p53 TERT). Cell senescence assessed by colorimetric assays beta‐galactosidase potential, revealing ability treated counteract free radical as result oxidative stress. Finally, mutations induced photo were studied. results obtained demonstrated that tested products elicit positive on all populations, preserving them senescence, being also able increase repairing mechanisms inducing youngest phenotype.

Language: Английский

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Advances in enhancing photoprotection of sunscreens using hydrocarbon film formers and carbon nanomaterials

Advanced Drug Delivery Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 115607 - 115607

Published: May 1, 2025

Language: Английский

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Exploring the Therapeutic Potential of Plant Extract-Loaded Polymeric Nanoparticles for Advanced Wound Healing: A Comprehensive Review

Arabian Journal for Science and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

Language: Английский

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Ecotoxicological assessment of UV filters benzophenone-3 and TiO ₂ nanoparticles, isolated and in a mixture, in developing zebrafish ( Danio rerio )

Journal of Toxicology and Environmental Health, Journal Year: 2024, Volume and Issue: 87(17), P. 687 - 700

Published: June 5, 2024

The increasing use of UV filters, such as benzophenone-3 (BP-3) and titanium dioxide nanoparticles (TiO2 NPs), has raised concerns regarding their ecotoxicological effects on the aquatic environment. aim present study was to examine embryo-larval toxicity attributed BP-3 or TiO2 NPs, either alone in a mixture, utilizing zebrafish (Danio rerio) model after exposure environmentally relevant concentrations these compounds. Zebrafish embryos were exposed (10, 100, 1000 ng/L) NPs (1000 mixture (BP-3 10, ng/L plus NPs) under static conditions for 144 hr. After exposure, levels determined by high-performance liquid chromatography (HPLC). increased presence indicating that degradation decreased NPs. In addition, zebrafish, water decreased, larvae might absorb BP-3. Data demonstrated that, general, did not significantly induce changes heart spontaneous contractions frequencies, reactive oxygen species (ROS), morphological morphometric parameters well mortality rates during hr exposure. However, groups with at 10 exhibited an earlier significant hatching rate than controls. Altogether, data indicates potential impact environment exists.

Language: Английский

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Cell Culture and Animal Models of Nanoparticle Toxicity on the Airway Barrier

Published: June 24, 2024

The production of nanoparticles has recently surged due to their varied applications in biomedical, pharmaceutical, textile, and electronic sectors. However, this rapid increase nanoparticle manufacturing raised concerns about environmental pollution, particularly potential adverse effects on human health. Among the various concerns, inhalation exposure poses significant risks, especially affecting respiratory system. Airway epithelial cells play a crucial role as primary defense against inhaled particulate matter pathogens. Studies have shown that can disrupt airway barrier, triggering inflammatory responses, generating reactive oxygen species, compromising cell viability. our understanding how different types specifically impact barrier remains limited. To investigate nanoparticle-induced cellular responses dysfunction, both vitro culture models vivo murine are commonly utilized. In review, we discuss methodologies frequently employed assess toxicity disruption. Furthermore, analyze compare distinct barrier. By elucidating diverse elicited by nanoparticles, aim provide insights guide future research endeavors assessing mitigating risks associated with exposure.

Language: Английский

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