Micro,
Journal Year:
2024,
Volume and Issue:
4(4), P. 734 - 750
Published: Nov. 27, 2024
Mycoplasma
infections
pose
significant
challenges
in
the
poultry
industry,
necessitating
effective
therapeutic
interventions.
Tiamulin,
a
veterinary
antibiotic,
has
demonstrated
efficacy
against
species.
However,
emergence
of
resistant
species
could
dramatically
reduce
potential,
contributing
to
economic
losses.
Optimizing
tiamulin’s
pharmacokinetic
profile
via
nanocarrier
incorporation
enhance
its
potential
and
administration
frequency,
ultimately
reducing
strain
emergence.
Niosomes,
type
self-assembled
non-ionic
surfactant-based
nanocarrier,
have
emerged
as
promising
drug
delivery
system,
offering
improved
stability,
sustained
release,
enhanced
bioavailability.
In
this
study,
niosomal
nanocarriers
encapsulating
tiamulin
were
prepared,
characterized
assessed
Mycoplasma-inoculated
broilers
following
oral
administration.
Differential
scanning
colorimetry
(DSC)
confirmed
alterations
crystalline
state
components
integration
into
structures
formed
during
formulation
procedure.
Transmission
electron
microscopy
(TEM)
showed
spherical
nanostructure
niosomes.
The
formulated
exhibited
zeta
average
hydrodynamic
diameter
−10.65
±
1.37
mV
339.67
30.88
nm,
respectively.
Assessment
parameters
gallisepticum-infected
revealed
ability
increase
bioavailability
systemic
exposure,
marked
by
significantly
higher
area
under
curve
(AUC)
(p
<
0.01)
prolonged
elimination
half-life
(T1/2)
0.05).
Enhanced
residence
time
are
crucial
factors
maintaining
concentrations
at
reduced
doses
frequencies.
This
approach
provides
viable
strategy
decrease
risk
subtherapeutic
levels,
thereby
mitigating
development
antibiotic
resistance.
findings
presented
herein
offer
sustainable
for
efficient
use
antibiotics
medicine.
Materials Advances,
Journal Year:
2024,
Volume and Issue:
5(10), P. 4112 - 4130
Published: Jan. 1, 2024
Peptide
nanofibers
have
exhibited
a
remarkable
ability
to
enhance
immune
response
induction.
Herein,
we
explore
the
peptide
nanofibers'
transformative
potential,
providing
comprehensive
examination
of
their
application
in
vaccine
development.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(10), P. 1282 - 1282
Published: Sept. 30, 2024
Carboplatin
(Cp)
is
a
potent
chemotherapeutic
agent,
but
its
effectiveness
constrained
by
associated
side
effects.
Frankincense,
an
oleo-gum
resin
from
the
Nanotechnology Reviews,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: Jan. 1, 2024
Abstract
In
this
study,
we
prepared
an
inclusion
complex
of
picoplatin
(Pc)
with
2-hydroxy
propyl
β
cyclodextrin
(HPCD)
to
improve
its
hydrophilicity,
yielding
Pc-HPCD.
The
Pc-HPCD
was
encapsulated
into
PEG-PLGA
nanoparticles
(NPs)
using
the
emulsion–solvent
evaporation
method,
Pc-HPCD@PEG-PLGA
core–shell
NPs.
assessed
1
HNMR
spectroscopy
and
a
phase
solubility
study.
addition,
average
hydrodynamic
diameter,
polydispersity
index,
zeta
potential,
encapsulation
efficiency
(EE%)
NPs
were
190.2
±
8.7
nm,
0.14
0.02,
−13.97
0.67
mV,
80.7
2.4%,
respectively.
vitro
release
study
showed
pH-triggered
manner.
Furthermore,
biological
evaluation
revealed
significantly
potent
cytotoxic
activity
(IC
50
=
1.6
0.24
µg/ml)
against
triple-negative
breast
cancer
cells
(TNBC),
surpassing
that
5.3
0.93
Pc
7.5
0.4
µg/ml).
induced
significant
apoptosis
ability
arrest
at
sub-G1
in
MDA-MB-231
cells.
Moreover,
vivo
model
established
SEC-bearing
mice,
treatment
demonstrated
inhibition
tumor
proliferation
(67.2%).
This
accompanied
by
improvements
hematological
biochemical
measurements,
as
well
histopathological
examination,
which
indicated
reduction
cellular
nuclear
pleomorphism.
Our
potential
be
employed
effective
safe
therapy
capable
conquering
TNBC.
Artificial Cells Nanomedicine and Biotechnology,
Journal Year:
2024,
Volume and Issue:
52(1), P. 529 - 550
Published: Oct. 27, 2024
Lens
culinaris
L.,
has
been
widely
recognized
for
its
medical
applications.
LC-ESI-TOF-MS
identified
22
secondary
metabolites
including
phenolics,
flavonoids,
and
anthocyanidin
glycosides
among
total
extract
(LCTE).
The
study
aimed
to
apply
LCTE
as
a
biogenic
material
reducing
capping
the
silver
nanoparticles
(LC-AgNPs).
ynthesized
LC-AgNPs
were
characterized
using
different
techniques.
UV
absorption
was
observed
at
λmax
379
nm.
spherical,
with
19.22
nm
average
size.
face
cubic
centre
nature
demonstrated
by
HR-TEM
XRD.
then
evaluated
their
anticancer
antimicrobial
potentials.
showed
an
extremely
potent
cytotoxic
activity
against
MCF-7,
HCT-116
HepG2
cell
lines
(IC50=
0.37,
0.35
0.1
µg/mL,
respectively).
induced
significant
apoptotic
effects
in
three
examined
cancer
lines.
resulted
sequestration
of
cells
G1
phase
cycle
both
MCF-7
cells,
meanwhile
it
trapped
G2
cells.
Moreover,
highly
confirmed
Klebsiella
pneumoniae
Acinetobacter
baumannii.
Molecular
docking
designated
Kaempferol-3-O-robinoside-7-O-rhamnoside
Quercetin-3-D-xyloside
topmost
active
constituents
that
caused
inhibition
Bcl-2
IspC
targets
combination
produced
nanoparticles.
Open Chemistry,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Jan. 1, 2024
Abstract
The
sixth
most
common
cancer
in
the
world,
esophageal
cancer,
requires
aggressive
treatment
such
as
surgery,
chemotherapy,
radiotherapy,
and
immunotherapy.
Phytochemicals
medicinal
plants
are
being
used
green
synthesis
of
nanoparticles.
Our
study
aimed
to
synthesize
ZnO–SnO
2
nerolidol
nanocomposite
its
effects
on
squamous
cell
carcinoma
cells.
UV
spectroscopy
showed
significant
absorbance
at
288
nm,
transmission
electron
microscopy
DLS
spherical
shapes,
also
108
nm
average
diameters.
was
investigated
using
energy-dispersive
X-ray
analysis,
Fourier
transform
infrared
spectroscopy,
photoluminescence,
field
emission
scanning
microscopy.
A
cytotoxic
effect
observed
against
KYSE-150
cells
with
an
IC
50
concentration
14.9
μg/mL.
inhibited
proliferation
enhanced
apoptosis
by
altering
mitochondrial
membrane
potential.
oxidative
stress,
leading
a
decrease
superoxide
dismutase,
catalase,
glutathione
increase
lipid
peroxidation.
Ultimately,
caspase
cascade
inducing
caspases
3,
8,
9
On
whole,
we
suggest
that
can
be
effective
strategy
However,
understanding
molecular
circuits
is
still
warranted.
