Preparation and Characterization of Tiamulin-Loaded Niosomes for Oral Bioavailability Enhancement in Mycoplasma-Infected Broilers DOI Creative Commons

Shimaa G. Abonashey,

Amr Gamal, Hatem A. F. M. Hassan

et al.

Micro, Journal Year: 2024, Volume and Issue: 4(4), P. 734 - 750

Published: Nov. 27, 2024

Mycoplasma infections pose significant challenges in the poultry industry, necessitating effective therapeutic interventions. Tiamulin, a veterinary antibiotic, has demonstrated efficacy against species. However, emergence of resistant species could dramatically reduce potential, contributing to economic losses. Optimizing tiamulin’s pharmacokinetic profile via nanocarrier incorporation enhance its potential and administration frequency, ultimately reducing strain emergence. Niosomes, type self-assembled non-ionic surfactant-based nanocarrier, have emerged as promising drug delivery system, offering improved stability, sustained release, enhanced bioavailability. In this study, niosomal nanocarriers encapsulating tiamulin were prepared, characterized assessed Mycoplasma-inoculated broilers following oral administration. Differential scanning colorimetry (DSC) confirmed alterations crystalline state components integration into structures formed during formulation procedure. Transmission electron microscopy (TEM) showed spherical nanostructure niosomes. The formulated exhibited zeta average hydrodynamic diameter −10.65 ± 1.37 mV 339.67 30.88 nm, respectively. Assessment parameters gallisepticum-infected revealed ability increase bioavailability systemic exposure, marked by significantly higher area under curve (AUC) (p < 0.01) prolonged elimination half-life (T1/2) 0.05). Enhanced residence time are crucial factors maintaining concentrations at reduced doses frequencies. This approach provides viable strategy decrease risk subtherapeutic levels, thereby mitigating development antibiotic resistance. findings presented herein offer sustainable for efficient use antibiotics medicine.

Language: Английский

Preparation and Characterization of Tiamulin-Loaded Niosomes for Oral Bioavailability Enhancement in Mycoplasma-Infected Broilers DOI Creative Commons

Shimaa G. Abonashey,

Amr Gamal, Hatem A. F. M. Hassan

et al.

Micro, Journal Year: 2024, Volume and Issue: 4(4), P. 734 - 750

Published: Nov. 27, 2024

Mycoplasma infections pose significant challenges in the poultry industry, necessitating effective therapeutic interventions. Tiamulin, a veterinary antibiotic, has demonstrated efficacy against species. However, emergence of resistant species could dramatically reduce potential, contributing to economic losses. Optimizing tiamulin’s pharmacokinetic profile via nanocarrier incorporation enhance its potential and administration frequency, ultimately reducing strain emergence. Niosomes, type self-assembled non-ionic surfactant-based nanocarrier, have emerged as promising drug delivery system, offering improved stability, sustained release, enhanced bioavailability. In this study, niosomal nanocarriers encapsulating tiamulin were prepared, characterized assessed Mycoplasma-inoculated broilers following oral administration. Differential scanning colorimetry (DSC) confirmed alterations crystalline state components integration into structures formed during formulation procedure. Transmission electron microscopy (TEM) showed spherical nanostructure niosomes. The formulated exhibited zeta average hydrodynamic diameter −10.65 ± 1.37 mV 339.67 30.88 nm, respectively. Assessment parameters gallisepticum-infected revealed ability increase bioavailability systemic exposure, marked by significantly higher area under curve (AUC) (p < 0.01) prolonged elimination half-life (T1/2) 0.05). Enhanced residence time are crucial factors maintaining concentrations at reduced doses frequencies. This approach provides viable strategy decrease risk subtherapeutic levels, thereby mitigating development antibiotic resistance. findings presented herein offer sustainable for efficient use antibiotics medicine.

Language: Английский

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