Nanomedicine,
Journal Year:
2024,
Volume and Issue:
20(3), P. 319 - 328
Published: Dec. 24, 2024
The
maturation
of
cardiomyocytes
(CMs)
plays
key
roles
in
regenerative
medicine
and
the
treatment
cardiovascular
diseases
via
stem
cell-derived
CMs.
Carbon
dots
(CDs)
have
good
biocompatibility,
optical
properties,
electrophysical
properties
been
widely
applied
bioimaging,
biosensors,
biotherapy.
In
this
review,
we
comprehensively
summarize
recent
advances
promoting
CMs,
mainly
human
pluripotent
related
medicine.
Moreover,
explore
innovative
application
CDs
to
enhance
these
Finally,
look
forward
future
design
CMs
terms
cell
therapies.
Journal of Advances in Medicine and Medical Research,
Journal Year:
2025,
Volume and Issue:
37(1), P. 23 - 40
Published: Jan. 8, 2025
Activated
carbon
(AC),
a
highly
porous
and
low-cost
material,
was
tested
as
biosubstitute
material
for
healing
bone
defects.
The
aim
of
this
work
to
investigate
the
use
4
different
activated
materials
in
tissue
repair
process,
verifying
morphological
biomechanical
aspects
bone.
Experiments
were
performed
by
drilling
rat
tibias
filling
resultant
cavities
with
four
kinds
ACs
(AC1,
2,
3
e
4).
A
Control
group
(CTL)
untreated
lesion
(NT)
also
included.
efficiency
evaluated
after
30
days.
No
alteration
hepatic
renal
activity
found,
both
histological
evaluation
those
organs
levels
SGOT/SGTP
urea.
An
increase
ALP
observed
NT
group,
while
all
groups
maintained
enzyme
close
values
CTL
group.
study
carried
out
evaluate
organization
formed
tissue,
compared
quality
treatment.
properties
(Maximal
Force
=
Fmax
Maximal
Deformation
Dmax)
three-point
flexural
tests.
presented
immature
and,
although
AC1,
AC2
AC3
granulation
indicating
delay
organization,
similar
Group
AC4
showed
mechanical
carbons
allow
growth
tibial
defect
model.
However,
specific
structural
characteristics
are
important
may
contribute
better
since
results
than
materials.
In
conclusion,
(Norit
ROX0.8)
enabled
organized
normal
CTL,
superior
performance
be
related
its
characteristics.
ACS Omega,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 29, 2025
The
piezoresistive
properties
of
the
modified
cryogels
were
studied.
pressure
sensitivity
cryogel:MWCNT
(CG:MWCNT)
sensors
for
different
concentrations
MWCNTs
are
FTIR
characterization
confirms
formation
CG
and
CG:MWCNT
nanocomposites.
Porosity
was
optimized
to
enhance
conductivity
nanocomposite
by
studying
various
concentrations.
highly
porous
structure
elastic
nature
resulted
in
a
change
electrical
percolation
even
subtle
application,
linear
observed
up
700
kPa.
minimum
maximum
pressures
detected
0.4
kPa,
respectively.
Electromechanical
tests
confirm
high
responsive
time
no
effect
pore
size
after
stability
test,
which
makes
prepared
sensor
more
span
usage
healthcare
conditions.
Further,
wearable
wireless
module
developed,
gait
signals
acquired
wirelessly.
system
is
able
differentiate
between
normal,
fast,
slow
gaits.
FFT
analysis
has
been
performed
understand
repeatability
signals.
Overall,
study
emphasizes
potential
developed
assisting
professionals,
researchers,
individuals
assessing
characteristics
tracking
exercise
performance.
Beilstein Journal of Nanotechnology,
Journal Year:
2025,
Volume and Issue:
16, P. 229 - 251
Published: Feb. 19, 2025
In
the
present
study,
temozolomide
(TMZ),
a
drug
used
for
treatment
of
anaplastic
astrocytoma
and
glioblastoma
multiforme
(GBM),
was
incorporated
into
multiwalled
carbon
nanotubes
(MWCNTs)
MWCNTs-graphene
(MWCNTs-G)
hybrid
compound,
covalently
functionalized
with
polyethylene
glycol
(PEG)
6000
folic
acid
(FA),
an
aim
to
prepare
nanocarriers
potential
prolong
circulation
time,
cross
blood-brain-tumor
barrier
(BBTB),
provide
targeted
controlled
release
in
brain
tumor
cells.
Cytotoxicity
effects
on
cell
membrane
integrity
blank
TMZ-loaded
dual-functionalized
nanostructures
(CNs)
were
evaluated
vitro
GBM
line
(U87MG),
as
well
their
radiosensitizing
properties
after
exposure
pre-treated
cells
gamma
radiation
standard
clinical
dose
patients
GBM.
All
prepared
formulations
underwent
biopharmaceutical
physicochemical
characterization,
including
exposed
irradiation
under
same
conditions.
For
characterization
formulations,
different
techniques
by
which
successful
functionalization
CNs
TMZ
loading
confirmed
visualized;
no
significant
changes
structure
observed.
With
single
dual
functionalization,
relatively
high
efficiency
content
prepared.
They
exhibited
homogeneous
particle
size
distributions
mean
sizes
surface
charges
suitable
crossing
BBTB
targeting
cancer
A
biphasic
profile
observed
all
simulated
vivo
conditions,
sustained
pointing
The
CN
MWCNTs-G
compared
corresponding
MWCNTs
characterized
similar
or
slightly
higher
content,
larger
size,
charge,
faster
release,
can
be
attributed
planar
graphene
that
promotes
binding
scale.
irradiated
CNs,
lower
values
more
positive
accelerated
observed,
could
explained
characteristics
upon
irradiation.
Significant
concentration-dependent
toxicity
being
MWCNTs-G-PEG6000-FA
MWCNTs-PEG6000-FA
at
formulation
concentrations.
incorporation
viability
additionally
decreased,
maintaining
trend
cytotoxicity
CN.
Additional
decrease
when
irradiation,
ascribed
kinetics
irradiation-induced
microenvironment
membranes
promote
uptake
volume
carriers
carrier
most
likely
length
proportion
surface,
intense
contact
rupture
membranes.
Overall,
findings
demonstrate
not
only
but
also
point
benefit
from
combined
radiotherapy
