Fine-Tuning the Excited-State Dynamics of Heteroleptic Ruthenium(II) Polypyridyl Complexes with Systematic Variation of Benzazole-Substituted 8-Hydroxyquinolines DOI
Abhijit Saha, Subhas C. Kundu, Mahendra K. Verma

et al.

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

A series of structurally related bistridentate heteroleptic Ru(II) polypyridyl complexes, [RuII(ttpy)(8-HQLS/N/O)]+ (Ru1-Ru3), were synthesized, where ttpy = p-tolyl terpyridine and 8-HQLS/N/O are monoanionic N^N^O-donor tridentate ligands (8-HQLX), derived from 8-hydroxyquinoline (8-HQ), namely, 8-HQLS 2-(2'-benzothiazole)-8-hydroxyquinoline, 8-HQLN 2-(2'-benzimidazole)-8-hydroxyquinoline, 8-HQLO 2-(2'-benzoxazole)-8-hydroxyquinoline. The electronic structures these rigid systematically tuned by varying the noncoordinating heteroatoms (S, O, NH) in five-membered heterocyclic ring, impacting properties, redox potentials, excited-state lifetime/dynamics, deactivation pathways photophysical behavior corresponding complexes. Notably, [RuII(ttpy)(8HQLN)]+ (Ru2) exhibited an lifetime (τ > 1 ns CH3CN at RT) surpassing that homoleptic complex [Ru(ttpy)2]2+ ∼ 0.62 ns), despite its more distorted octahedral geometry. These complexes (Ru1-Ru3) showed extended lifetimes compared to their counterpart Ru4. displayed absorption red region, which is favorable for phototherapeutic applications. Their relative singlet oxygen (1O2) quantum yields (ΦΔ) ranged 0.03 0.10. Given reasonable 1O2 generation ability, demonstrated potential as photocatalysts organic substrates, evidenced effectiveness photooxidation PPh3 Ph3P=O a model reaction.

Language: Английский

Intracellular Photocatalytic NADH/NAD(P)H Oxidation for Cancer Drug Development DOI
Ashish Yadav, Samya Banerjee,

Arif Ali Mandal

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: 147(9), P. 7161 - 7181

Published: Feb. 20, 2025

Photocatalytic cancer therapy (PCT) has emerged as a cutting-edge anticancer mechanism of action, harnessing light energy to mediate the catalytic oxidation intracellular substrates. PCT is significant current importance due its potential address limitations conventional chemotherapy, particularly drug resistance and side effects. This approach offers noninvasive, targeted treatment option by utilizing metal-based photocatalysts induce redox metabolic disorders within cells. The disrupt cell metabolism converting NADH/NAD(P)H NAD+/NAD(P)+ via photoredox processes, altering NAD+/NADH or NAD(P)+/NAD(P)H ratios, which are crucial for cellular metabolism. Ir(III), Ru(II), Re(I), Os(II) demonstrated promising efficacy. Despite these developments, gaps remain in literature translating this new into clinical trials. Perspective critically examines developments research area provides future directions designing efficient PCT.

Language: Английский

Citations

0
Anticancer potential of polypyridyl-based Ir(III)-coumarin 6 conjugates under visible light and dark DOI
Ashish Kumar Yadav, Virendra Singh, Samya Banerjee

et al.

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114184 - 114184

Published: Feb. 1, 2025

Language: Английский

Citations

0
Near-Infrared Light Activatable Iridium(III) Complexes for Synergistic Photodynamic and Photochemotherapy DOI Creative Commons

Monika Negi,

V. Venkatesh

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

NIR activatable, self-degradable iridium( iii )–dithiocarbamate–cyanine complexes were synthesized. They act as type I and II PDT agent at ultra-low-power irradiation high laser power, they exhibited photoactivated chemotherapy (PACT).

Language: Английский

Citations

0
Exploring the Phototherapeutic Applications of Mitochondria-Targeted COUPY Photocages of Antitumor Drugs DOI

Marta López‐Corrales,

Eduardo Izquierdo‐García, Manel Bosch

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 68(9), P. 9741 - 9754

Published: April 28, 2025

Photocleavable protecting groups hold great promise in photopharmacology to control the release of bioactive molecules from their caged precursors within specific subcellular compartments. Herein, we describe a series photocages based on COUPY scaffold, incorporating chlorambucil (CLB) and 4-phenylbutyric acid (4-PBA) as payloads that can be efficiently activated with visible light. Confocal microscopy confirmed preferential accumulation CLB 4-PBA N-hexyl mitochondria, which exhibited remarkable phototoxicity against cancer cells upon green-yellow light irradiation, IC50 values nanomolar range. This effect was attributed synergistic mechanism involving photorelease intrinsic photogeneration Type I II ROS by scaffold mitochondria. Thus, COUPY-caged derivatives underscore potential COUPY-caging versatile platform develop innovative light-activated agents operating simultaneously through photodynamic therapy photoactivated chemotherapy.

Language: Английский

Citations

0
Fine-Tuning the Excited-State Dynamics of Heteroleptic Ruthenium(II) Polypyridyl Complexes with Systematic Variation of Benzazole-Substituted 8-Hydroxyquinolines DOI
Abhijit Saha, Subhas C. Kundu, Mahendra K. Verma

et al.

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

A series of structurally related bistridentate heteroleptic Ru(II) polypyridyl complexes, [RuII(ttpy)(8-HQLS/N/O)]+ (Ru1-Ru3), were synthesized, where ttpy = p-tolyl terpyridine and 8-HQLS/N/O are monoanionic N^N^O-donor tridentate ligands (8-HQLX), derived from 8-hydroxyquinoline (8-HQ), namely, 8-HQLS 2-(2'-benzothiazole)-8-hydroxyquinoline, 8-HQLN 2-(2'-benzimidazole)-8-hydroxyquinoline, 8-HQLO 2-(2'-benzoxazole)-8-hydroxyquinoline. The electronic structures these rigid systematically tuned by varying the noncoordinating heteroatoms (S, O, NH) in five-membered heterocyclic ring, impacting properties, redox potentials, excited-state lifetime/dynamics, deactivation pathways photophysical behavior corresponding complexes. Notably, [RuII(ttpy)(8HQLN)]+ (Ru2) exhibited an lifetime (τ > 1 ns CH3CN at RT) surpassing that homoleptic complex [Ru(ttpy)2]2+ ∼ 0.62 ns), despite its more distorted octahedral geometry. These complexes (Ru1-Ru3) showed extended lifetimes compared to their counterpart Ru4. displayed absorption red region, which is favorable for phototherapeutic applications. Their relative singlet oxygen (1O2) quantum yields (ΦΔ) ranged 0.03 0.10. Given reasonable 1O2 generation ability, demonstrated potential as photocatalysts organic substrates, evidenced effectiveness photooxidation PPh3 Ph3P=O a model reaction.

Language: Английский

Citations

0