Transcription Factor Engineering in Aspergillus nidulans Leads to the Discovery of an Orsellinaldehyde Derivative Produced via an Unlinked Polyketide Synthase Gene DOI
Chris Rabot, Michelle F. Grau,

Ruth Entwistle

et al.

Journal of Natural Products, Journal Year: 2024, Volume and Issue: 87(10), P. 2384 - 2392

Published: Sept. 27, 2024

Secondary metabolites are generally produced by enzymes encoded genes within a biosynthetic gene cluster. Transcription factor frequently located these clusters. These transcription factors often drive expression of the other cluster, and overexpression provides facile approach to express all resulting in production downstream metabolite(s). Unfortunately this is not always successful, leading us engineer more effective hybrid factors. Herein, we attempted activate putative cryptic cluster

Language: Английский

Transcription Factor Engineering in Aspergillus nidulans Leads to the Discovery of an Orsellinaldehyde Derivative Produced via an Unlinked Polyketide Synthase Gene DOI
Chris Rabot, Michelle F. Grau,

Ruth Entwistle

et al.

Journal of Natural Products, Journal Year: 2024, Volume and Issue: 87(10), P. 2384 - 2392

Published: Sept. 27, 2024

Secondary metabolites are generally produced by enzymes encoded genes within a biosynthetic gene cluster. Transcription factor frequently located these clusters. These transcription factors often drive expression of the other cluster, and overexpression provides facile approach to express all resulting in production downstream metabolite(s). Unfortunately this is not always successful, leading us engineer more effective hybrid factors. Herein, we attempted activate putative cryptic cluster

Language: Английский

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