Site-selective cleavage of peptides and proteins targeting aromatic amino acid residues

RSC Advances, Journal Year: 2025, Volume and Issue: 15(12), P. 9159 - 9179

Published: Jan. 1, 2025

This review provides an account of the site-selective cleavage peptides and proteins at aromatic amino acid residues, developed over last seven decades (1958–2024).

Language: Английский

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Physicochemical and biochemical characterization of antimicrobial peptides

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 259 - 299

Published: Jan. 1, 2025

Language: Английский

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Peptide PET Imaging: A Review of Recent Developments and a Look at the Future of Radiometal-Labeled Peptides in Medicine

Chemical & Biomedical Imaging, Journal Year: 2024, Volume and Issue: 2(9), P. 615 - 630

Published: Aug. 23, 2024

The development of peptide-based, radiometal-labeled PET imaging agents has seen an increase in attention due to the favorable properties peptide backbone exhibits. These include high selectivity and affinity proteins cells directly linked various types cancers. In addition, rapid clearance from circulation low toxicity allow for unique approaches engineering a viable peptide-based agent. Utilizing peptides as allows modifications improve metabolic stability, target cell affinity, image quality capabilities reduce toxicity. Select radiolabeled have already been FDA approved, with many more late-stage trials. This review summarizes current state field well explores methods used by researchers modify peptides, concluding look at future therapy diagnostics.

Language: Английский

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Recent Progress in Electrochemical Modification of Amino Acids and Peptides

Chinese Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 44(3), P. 903 - 903

Published: Jan. 1, 2024

Language: Английский

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Understanding the Specific Implications of Amino Acids in the Antibody Development

The Protein Journal, Journal Year: 2024, Volume and Issue: 43(3), P. 405 - 424

Published: May 9, 2024

Language: Английский

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Basis Electronic Activity of Molecular Systems. A Theory of Bond Reactivity

The Journal of Physical Chemistry A, Journal Year: 2024, Volume and Issue: 128(10), P. 1902 - 1912

Published: March 4, 2024

In this paper, we present a new finding, the basis electronic activity (BEA) of molecular systems; it corresponds to significant, although nonreactive, vibrationally induced that takes place in any system. Although molecule's BEA is composed an equal number local contributions as vibrational degrees freedom, our results indicate only stretching modes contribute it. To account for activity, descriptor, bond flux (BEF), introduced. The BEF combined with force constant potential well hosting gives rise effective reactivity index (EBR), which turns out be first density functional theory-based descriptor simultaneously accounts structural and effects. Besides quantifying reactivity, EBR provides compare reactivities bonds inserted different chemical environments paves way exertion selective control enhance or inhibit their reactivities. concepts formulated paper associated computational tools are illustrated characterization set representative molecules. all cases, BEFs follow same linear pattern, whose slopes intensity quantify bonds.

Language: Английский

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Discovery and development of tyrosine-click reaction for the site-selective labelling of proteins.

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This highlight provides an account of the discovery and advances in tyrosine-click (Y-click) reaction its extensive application mapping proteins, imaging living cells, fields analytical medicinal chemistry.

Language: Английский

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Triazination/IEDDA Cascade Modular Strategy Installing Pyridines/Pyrimidines onto Tyrosine Enables Peptide Screening and Optimization

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Modular chemical postmodification of peptides is a promising strategy that supports the optimization and innovation hit peptide therapeutics by enabling rapid derivatization. However, current methods are primarily limited to traditional bio-orthogonal strategies ligation techniques, which require preintroduction non-natural amino acids impose fixed limit diversity. Here, we developed Tyrosine-1,2,3-Triazine Ligation (YTL) strategy, constructs novel linkages (pyridine pyrimidine) through "one-pot, two-step" process combining SNAr IEDDA reactions, promoting modular post modification Tyr-containing peptides. After optimizing YTL establishing standard procedures, successfully applied it solid-phase various biorelated peptides, such as synthesis dual-mode imaging probes long-acting GLP-1 analogs. As proof concept, library 384 amphipathic was constructed using based on 96-well microfiltration plates. modifications were then performed screened template tripeptide RYR, leading generation 20 derivatives. The antibacterial activity these derivatives systematically characterized, identifying Z8 potential candidate.

Language: Английский

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BIOPROSPECTING ANTARCTIC ACTINOBACTERIA:DISCOVERY OF FUNCTIONAL CRYOPROTECTIVE PROTEINS FOR INNOVATIONS IN FOOD SCIENCES AND BIOMEDICAL APPLICATIONS

Food Bioscience, Journal Year: 2025, Volume and Issue: 66, P. 106134 - 106134

Published: Feb. 14, 2025

Language: Английский

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Application of Ozone Technology on Soymilk and Its Impact on Product Characteristics

Ozone Science and Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: April 13, 2025

Language: Английский

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