Late-Stage Radical C–H Alkylamination of Tyrosine Compounds and Phenol-Containing Drugs DOI
Paula Andrade‐Sampedro, Arkaitz Correa

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

A modular site-selective iron-catalyzed radical amination of a number phenol-containing biomolecules such as tyrosine-containing peptides, estrogens, and other phenol-based pharmaceuticals has been developed. The method features the use cost-efficient combination FeBr

Language: Английский

Triflic Acid-Mediated Chemoselective Indole C2-Heteroarylation of Peptide Tryptophan Residues by Triazine DOI
Jian Li, Qi-Long Hu,

Jia-Shu Liu

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Peptide modification provides opportunities to afford peptides with designed functions. Among the proteogenic amino acids, tryptophan represents an ideal and attractive target for peptide because of exclusive chemical reactivity its unique indole structure. Herein, we reported C2 position-selective transition-metal-free approach derivatives tryptophan-containing by triazine via triflic acid activation that incorporated functional group could act as orthogonal handle further bioconjugation inverse electron demand Diels–Alder reaction.

Language: Английский

Citations

1
Pinpointing Acidic Residues in Proteins DOI
Weimin Xuan, Jun‐An Ma

ChemMedChem, Journal Year: 2024, Volume and Issue: 19(5)

Published: Feb. 2, 2024

Abstract It is of great importance to pinpoint specific residues or sites a protein in biological contexts enable desired mechanism action for small molecules precisely control function. In this regard, acidic including aspartic acid (Asp) and glutamic (Glu) hold potential due their prevalence unique To unlock the largely untapped potential, efforts have been made recently by synthetic chemists, chemical biologists pharmacologists. Herein, we would like highlight remarkable progress particularly introduce electrophiles that exhibit reactivity carboxylic acids, light‐induced reactivities acids genetically encoded noncanonical amino allow manipulations at residues. We also comment on certain unresolved challenges, hoping draw more attention rapidly developing area.

Language: Английский

Citations

0
Iridium-catalyzed diacylmethylation of tyrosines and its peptides with sulfoxonium ylides DOI Creative Commons

Narendra Dinkar Kharat,

Sushma Naharwal,

Siva S. Panda

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(59), P. 7622 - 7625

Published: Jan. 1, 2024

Pyridyloxy-directed Ir( iii )-catalyzed diacylmethylation of protected tyrosines was achieved with alkyl and (hetero)aryl sulfoxonium ylides, furnishing tyrosine-based unnatural amino acids in good yields.

Language: Английский

Citations

0
Mno4--Triggered Wavelength-Changeable and Rapid-Response Fluorescence Sensor for Paper-Based On-Site Sensing Tyrosinase Activity in Potato DOI
Yifei Ma, Xiaoxue Liu,

Lihua Pang

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Late-Stage Radical C–H Alkylamination of Tyrosine Compounds and Phenol-Containing Drugs DOI
Paula Andrade‐Sampedro, Arkaitz Correa

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

A modular site-selective iron-catalyzed radical amination of a number phenol-containing biomolecules such as tyrosine-containing peptides, estrogens, and other phenol-based pharmaceuticals has been developed. The method features the use cost-efficient combination FeBr

Language: Английский

Citations

0