Three‐Component 1,2‐Methylamidation of Alkynes via Coordinating Activation Strategy

ChemistryOpen, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

The selective functionalization of carbon–carbon triple bonds with methyl groups remains a challenging task. Herein, the successful development novel copper‐catalyzed three‐component 1,2‐methylamidation bond is reported. readily available coupling partners, picolinamides and alkynes dicumyl peroxide, serve as both source oxidant in this difunctional strategy to access methylated enamides; substrate scope broad, demonstrating good functional group compatibility. synthetic utility reaction also demonstrated through via late‐stage substrates bearing biologically relevant molecules.

Language: Английский

Vinyl radicals in transition metal-catalyzed organic transformations

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(18), P. 5202 - 5231

Published: Jan. 1, 2024

We summarize the advancements in transition metal-catalyzed organic transformations involving vinyl radicals and provide a categorical overview based on reaction types.

Language: Английский