Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(31)
Published: May 11, 2024
The
use
of
noncovalent
interactions
based
on
electrophilic
halogen,
chalcogen,
pnictogen,
or
tetrel
centers
in
organocatalysis
has
gained
noticeable
attention.
Herein,
we
provide
an
overview
the
most
important
developments
last
years
with
a
clear
focus
experimental
studies
and
catalysts
which
act
via
such
non-transient
interactions.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(18), P. 6770 - 6776
Published: Jan. 1, 2024
Polyhalogenated
biaryls
are
unique
motifs
offering
untapped
potential
as
versatile
building
blocks
for
the
expedient
synthesis
of
complex
biaryl
compounds.
ChemCatChem,
Journal Year:
2024,
Volume and Issue:
16(12)
Published: Feb. 21, 2024
Abstract
The
experimentally
obtained
kinetic
data
has
indicated
the
existence
of
a
synergetic
cocatalytic
effect
provided
by
an
iodonium
salt
in
base‐catalyzed
Knoevenagel
condensation.
diphenyliodonium
triflate
serving
as
halogen
bond‐donating
Lewis
acid
provides
higher
than
zinc(II)
or
triflic
serving,
respectively,
metal
cation‐based
and
Brønsted
acid.
Such
remains
same
for
broad
scope
carbonyl
compounds
covering
aldehydes
featuring
electron‐withdrawing
electron‐donating
substituents,
well
ketone
involved
reaction.
ChemCatChem,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 15, 2024
Abstract
Sulfonium,
selenonium,
telluronium
triflates,
as
well
chloronium,
bromonium,
and
iodonium
triflates
have
been
examined
in
the
model
Schiff
condensation
chalcogen‐
halogen
bond
donating
organocatalysts,
respectively.
The
kinetic
data
indicated
that
catalytic
effect
of
salt
is
provided
via
decrease
enthalpy
activation
reaction,
whereas
–
unexpectedly
caused
by
value
entropy
activation.
In
addition,
it
was
experimentally
shown
activity
sulfonium
selenonium
salts
significantly
lower
than
chloronium
bromonium
salts,
but
latter
pair
species
less
stable
under
reaction
conditions
former
pair.
Chalconium
and
halonium
salts
catalyze
Schiff
condensation.
Kinetic
data
DFT
calculations
show
that
the
catalytic
activity
correlates
with
maximum
electrostatic
potential
on
σ-holes,
whereas
other
factors
are
less
significant.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(4), P. 1753 - 1753
Published: Feb. 19, 2025
Polybrominated
biphenyls
(PBBs)
are
commonly
used
flame
retardants
that
pose
severe
risks
to
humans.
However,
there
is
a
lack
of
systematic
research
on
the
transformation
process
and
biological
toxicities
PBBs
in
environment,
which
not
conducive
prevention
control
pollution
PBBs.
Therefore,
pathways
(i.e.,
photodegradation,
microbial
degradation,
combustion
oxidation,
vivo
metabolism)
previously
designed
PBB
substitutes
were
deduced
first.
Then
potential
rodent
carcinogenicity,
toxicity,
mutagenicity,
developmental
skin
eye
irritation,
sensitization,
aquatic
toxicity
products
evaluated
using
toxicokinetics
(TOPKAT)
model.
Finally,
3D
quantitative
structure
activity
relationship
(3D-QSAR)
models
constructed
assess
human
hepatotoxicity,
epigenetic
neurotoxicity,
immunotoxicity)
PBBs,
substitutes,
their
products.
Results
showed
exhibit
high
toxicity)
organisms.
The
D3-A1
molecule
had
highest
carcinogenic
risk
probability
at
0.826.
dihydroxy
metabolite
2,2'-OH-PBB-80
PBB-80
presented
(toxicity
0.713).
dibenzofuran
(PBDF)
strongest
irritation
(probability
0.995).
oxidation
exhibited
higher
ecological
health
than
other
Among
humans,
was
theoretically
significant,
with
characterization
values
ranging
from
70.53
100.87.
This
first
study
comprehensively
evaluate
by
combining
inference
prediction
product
toxicities,
providing
theoretical
support
for
design
environmentally
friendly
future
studies.
Beilstein Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
21, P. 451 - 457
Published: Feb. 27, 2025
The
remarkable
nucleofugality
of
bromoarenes
in
diarylbromonium
species
renders
them
particularly
suitable
for
the
generation
arynes
subsequent
use
a
wide
range
synthetic
applications.
common
approach
to
generate
cyclic
biaryl
λ3-bromanes
is
based
on
thermal
decomposition
hazardous
diazonium
salts.
Herein,
we
disclose
mild
and
straightforward
by
direct
anodic
oxidation
2,2'-dibromo-1,1'-biphenyl.
electrochemical
method
provides
access
symmetrically
non-symmetrically
substituted
moderate
yields.
Chemical Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Diazomethyl-λ
3
-iodanes
have
recently
emerged
as
carbyne
equivalents
in
organic
synthesis,
enabling
the
construction
of
multi-substituted
carbon
centers
through
strategic
sequential
activation
diazo
and
iodane
functional
groups.
Distinct
from...
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 2, 2025
We
report
a
novel
coupling
strategy
enabled
by
cyclic
diphenylchloronium
salt
that
facilitates
reactions
between
sulfides
and
diverse
nucleophiles,
including
oxygen-
nitrogen-based
species.
The
methodology
efficiently
produces
structurally
varied
valuable
compounds,
carbamates,
carboxylic
esters,
aryl
ethers,
alkylated
amines,
under
mild,
operationally
simple
conditions.
protocol's
synthetic
utility
was
highlighted
through
modular
preparation
of
five
important
drugs
structural
analogues,
demonstrating
significant
potential
for
drug
discovery
applications.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(31)
Published: May 10, 2024
Abstract
Die
Anwendung
nichtkovalenter
Wechselwirkungen,
welche
auf
elektrophilen
Halogen‐,
Chalkogen‐,
Pniktogen‐
oder
Tetrelzentren
beruhen,
hat
in
der
Organokatalyse
deutlich
an
Aufmerksamkeit
gewonnen.
Wir
geben
hier
einen
Überblick
über
die
wichtigsten
Entwicklungen
letzten
Jahre,
mit
einem
Fokus
experimentellen
Studien
und
Katalysatoren,
nicht‐transiente
derartige
Welchselwirkungen
agieren.
