International Journal of Environmental & Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 20
Published: Dec. 5, 2024
A
novel
thiazole-based
heterocyclic
Schiff
base
(TSB)
was
designed
and
synthesised.
The
synthesised
structurally
characterised
by
using
fluorescence,
FT-IR
1H
NMR.
After
structural
characterisation,
the
sensing
properties
of
TSB
were
investigated
towards
different
metal
ions
such
as
Cr3+,
Hg2+,
Cu2+,
Cd2+,
Co2+,
Ni2+,
Zn2+,
Ag+,
Mg2+,
Ca2+,
Li+,
Na+,
K+.
significant
fluorescence
enhancement
observed
in
emission
at
584
nm
upon
interaction
with
Cu2+
compared
to
other
due
formation
TSB-Cu2+
complex.
2:1
binding
mode
between
confirmed
Job`s
plot
spectroscopy.
limit
detection
(LOD)
calculated
be
0.0051
ppm
(0.081
µM).
chemosensor
effectively
detected
various
environmental
samples,
demonstrating
high
recovery
rates
ranging
from
88.0
±
0.35%
107.0
0.47%.
antibacterial
activity
its
complex
also
evaluated
against
bacterial
strain.
results
showed
that
exhibited
good
activity,
highest
zone
inhibition
reaching
13.54
0.35
nm.
In
contrast,
consistently
demonstrated
improved
recorded
15.38
0.72
Critical Reviews in Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 27
Published: Jan. 21, 2025
Organic
fluorescence
and
colorimetric
probes
have
emerged
as
vital
tools
for
detecting
metal
ions,
due
to
their
high
sensitivity,
selectivity,
rapid
response
times.
Copper,
an
essential
trace
element,
plays
a
critical
role
in
biological
systems,
yet
its
imbalance
can
lead
severe
disorders
such
neurodegenerative
diseases,
cancer,
Wilson's
disease.
Over
the
past
few
years,
advancements
probe
design
unlocked
innovative
avenues
not
only
Cu2+
environmental
samples
but
also
visualizing
distribution
through
imaging.
These
offering
robust
performance
under
diverse
conditions.
Fluorescence
imaging
using
these
pivotal
cancer
diagnosis,
prognosis,
treatment
monitoring
by
real-time
visualization
of
tumor
morphology
biomolecular
interactions
at
cellular
tissue
levels.
This
review
aims
explore
diversity
organic
developed
detection
Cu2+,
with
particular
focus
on
applications
from
2020
2024.
The
discussion
highlights
use
various
cells
SiHa,
HCT
116,
GES-1,
RAW
264.7,
HepG2,
HeLa,
MCF-7
DrG
cell
lines,
tissues,
small
living
organisms.
By
targeting
cancer-specific
pathways
copper-related
physiological
changes,
significantly
advanced
fields
diagnostics
therapeutics.
comprehensive
analysis
emphasizes
potential
powerful
tool
elucidating
roles
health
disease,
paving
way
future
advances
biomedical
research.
Crystal Growth & Design,
Journal Year:
2024,
Volume and Issue:
24(3), P. 1051 - 1067
Published: Jan. 27, 2024
Considering
the
crisis
of
single
probes
for
simultaneous
colorimetric
detection
both
Cu2+
and
Pd2+
metal
ions,
which
are
toxic
to
living
organisms
even
in
trace
amounts,
this
communication,
we
report
facile
synthesis
characterization,
including
single-crystal
X-ray
diffraction
(SCXRD),
a
molecular
probe
(E)-3-((2-(methylthio)phenyl)diazenyl)-[1,1′-biphenyl]-4-ol
(TABH).
TABH
is
bioactive
avidly
interacts
with
biomolecules
such
as
BSA
protein
CT
DNA,
evidenced
by
spectrofluorometric
photometric
tests.
The
also
proficient
selective
swift
sensing
ions
ACN/H2O
(4/1
v/v,
pH
=
7.2)
medium
over
other
ions.
sensor's
ability
selectively
bind
analytes
demonstrated
noticeable
color
shift
from
yellow
reddish
brown
violet
Pd2+,
clearly
visible
human
eye.
A
detailed
investigation
recognition
mechanism
using
Job's
plot,
1H
nuclear
magnetic
resonance
(NMR),
infrared
(IR)
analysis,
electrospray
ionization
(ESI)
mass
density
functional
theory
(DFT)
calculations
confirmed
1:1
binding
stoichiometry
Furthermore,
chemosensor
exhibits
strong
association
affinity
(7.61
×
104
1.42
105
M–1
respectively)
low
limit
(54.8
5.32
nM
respectively).
Binding
data
absorption
studies
revealed
that
had
higher
than
Cu2+.
This
makes
it
simple
replace
[TAB-Cu2+]
complex,
increasing
Pd2+'s
differential
selectivity
reversible
addition
ethylenediaminetetraacetic
acid
(EDTA)
triphenylphosphine
(PPh3),
whereas
exclusively
presence
PPh3
only.
activities
were
investigated
logic
operations
AND,
OR,
NOT
gates.
In
addition,
chemoprobe
proved
be
effective
identifying
actual
water
samples.
It
was
then
converted
into
test
strips,
creating
portable
device
on-site
analysis
testing.
ACS Omega,
Journal Year:
2025,
Volume and Issue:
10(9), P. 9527 - 9536
Published: Feb. 25, 2025
This
study
reports
the
successful
synthesis
of
three
new
benzidine-based
chemosensors
(CRBD-1,
CRBD-2,
and
CRBD-3).
Among
these,
CRBD-1
CRBD-2
exhibited
exceptional
selectivity
ultrafast
response
toward
Cu2+
Hg2+
ions,
evident
by
a
distinct
naked-eye
color
change.
The
sensors
demonstrated
remarkable
stability
across
broad
pH
range
achieved
low
detection
limits
in
ppm
range.
displayed
high
binding
constant
for
(2.42
×
108)
(1.45
107).
Notably,
limit
(LOD)
(0.953
ppm)
(0.003
was
significantly
lower
than
established
safety
thresholds
set
WHO
ESEPA.
mechanism
sensing,
involving
intramolecular
charge
transfer
(ICT),
thoroughly
validated
using
UV–vis
spectroscopy,
1H
NMR,
cyclic
voltammetry,
DFT,
Job's
plot
analysis.
Furthermore,
reversibility
studies
enabled
development
logic
gate
operations
potential
future
applications.
functionality
successfully
evaluated
real-world
samples
like
vegetable
juice
water,
as
well
test
strips
convenient,
rapid,
qualitative,
quantitative,
colorimetric
aqueous
environments.
