Royal Society of Chemistry eBooks,
Journal Year:
2024,
Volume and Issue:
unknown, P. 228 - 260
Published: Dec. 20, 2024
The
previous
chapters
discuss
the
principle
and
uses
of
different
kinds
transduction
technologies
for
detecting
a
range
biomarkers.
Each
chapter
applies
specific
individual
techniques
irrespective
particular
However,
this
provides
an
overview
approaches
biomarkers
and/or
diseases.
For
instance,
various
designs
glucose
sensors
based
on
techniques,
viz.,
colorimetric
electrochemical
have
been
discussed.
Similarly,
detection
strategies
Alzheimer’s
disease
using
other
methods
(voltammetric,
amperometry,
impedimetric),
conductometric,
surface
plasmon
resonance,
included.
Several
commercialized
kits
cancer,
glucose,
HCG
also
Eventually,
concluding
remarks
are
given
such
Finally,
risk
assessment
legal
obligations
introducing
devices
discussed
in
present
context
future
development.
Sensors & Diagnostics,
Journal Year:
2024,
Volume and Issue:
3(6), P. 893 - 913
Published: Jan. 1, 2024
This
manuscript
emphasizes
advancements
in
electrochemical
sensors
for
real-time
glucose
monitoring,
showcasing
their
pivotal
role
enhancing
personalized
healthcare
through
continuous,
reliable
measurement
of
biochemical
markers.
European Journal of Medicinal Chemistry Reports,
Journal Year:
2024,
Volume and Issue:
12, P. 100192 - 100192
Published: July 31, 2024
Prostate-specific
antigen
(PSA)
remains
the
cornerstone
for
prostate
cancer
diagnosis.
This
study
presents
a
highly
sensitive
aptamer-based
electrochemical
biosensor
PSA
detection
utilizing
novel
two-dimensional
(2D):2D
reduced
graphene
oxide
(rGO)/graphitic
carbon
nitride
(g-C3N4)
composite
decorated
with
gold
nanoparticles
(Au
NPs).
The
aptamer
chains
were
immobilized
on
glassy
electrode
(GCE)
modified
rGO/g-C3N4/Au
NPs
composite.
successful
synthesis
of
nanomaterial
and
modification
confirmed
using
X-ray
diffraction
(XRD),
Fourier
transform
infrared
spectroscopy
(FTIR),
transmission
electron
microscopy
(TEM).
properties
selectivity
GCE
characterized
by
cyclic
voltammetry
(CV),
square
wave
(SQW),
impedance
(EIS).
exhibited
high
towards
compared
to
potential
interferents
like
carbohydrate
15-3
(CA
15-3),
bovine
serum
albumin
(BSA),
fetal
(FBS),
glucose
(C6H12O6).
Under
optimized
conditions,
achieved
rapid
time
30
min
remarkable
limit
(LOD)
0.44
fM
(femtomolar)
methylene
blue
(MB)
as
redox
mediator.
quantification
(LOQ)
was
also
exceptionally
low
at
2.5
fM.
applicability
developed
further
validated
analyzing
real
samples,
demonstrating
its
clinical
use.
Biosensors,
Journal Year:
2025,
Volume and Issue:
15(4), P. 203 - 203
Published: March 21, 2025
Ovarian
cancer
(OC)
is
one
of
the
leading
causes
gynecological
cancer-related
death
worldwide.
Late
diagnosis
at
advanced
stages
OC
reason
for
a
higher
mortality
rate.
Earlier
and
proper
treatment
are
important
improving
prognosis
patients.
Biosensors
offer
accurate,
low-cost,
rapid,
user-friendly
devices
that
can
be
employed
detection
OC-specific
biomarkers
in
early
stage.
Therefore,
it
to
consider
potential
biological
fluids
confirm
prognosis.
Out
many
biomarkers,
most
commonly
tested
clinically
antigen
125
(CA-125).
However,
CA-125
considered
poor
biomarker
diagnosis.
Several
biosensing
methods
were
developed
sensitive
quantitative
each
biomarker.
In
abnormal
expression
patients,
nucleic
acids,
enzymes,
cells,
exosomes
used
as
target
construction
biosensors.
This
review
focuses
on
development
various
using
multiple
methods.
Here,
we
describe
origin
significance
OC-associated
working
principle
biosensors,
classification
biosensors
based
their
recognition
elements
signal
transducers.
The
modes
sensitivity
sensors
discussed.
Finally,
challenges
fabrication,
obstacles
clinical
application,
future
prospects
Micromachines,
Journal Year:
2024,
Volume and Issue:
15(9), P. 1116 - 1116
Published: Aug. 31, 2024
Alpha-fetoprotein
(AFP)
is
a
key
marker
for
early
cancer
detection
and
assessment.
However,
the
current
methods
struggle
to
balance
accuracy
with
need
decentralized
medical
treatment.
To
address
this
issue,
new
AFP
analysis
platform
utilizing
digital
image
colorimetry
has
been
developed.
Functionalized
gold
nanoparticles
act
as
colorimetric
agents,
changing
from
purple-red
light
gray-blue
when
exposed
different
concentrations.
A
smartphone
app
captures
these
color
changes
calculates
concentration
in
sample.
improve
accuracy,
hardware
device
ensures
uniform
illumination.
Testing
confirmed
that
system
can
quantitatively
analyze
using
colorimetry.
The
limit
of
reached
0.083
ng/mL,
average
90.81%.
This
innovative
method
enhances
testing
by
offering
portability,
precision,
low
cost,
making
it
particularly
suitable
resource-limited
areas.
Biosensors,
Journal Year:
2024,
Volume and Issue:
14(9), P. 449 - 449
Published: Sept. 19, 2024
Gastrointestinal
cell
culture
technology
has
evolved
in
the
past
decade
with
integration
of
microfluidic
technologies,
bringing
advantages
greater
selectivity
and
cost
effectiveness.
Herein,
these
technologies
are
sorted
into
three
categories,
namely
cell-culture
insert
devices,
conventional
3D-printed
devices.
Each
category
is
discussed
brief
improvements
also
here.
Introduction
different
companies
applications
derived
from
each
provided
to
encourage
uptake.
Subsequently,
future
perspectives
integrating
microfluidics
trending
topics
like
stool-derived
vitro
communities
gut-immune-tumor
axis
investigations
discussed.
Insights
on
modular
its
implications
gastrointestinal
cultures
Future
point-of-care
(POC)
relations
devices
In
conclusion,
this
review
presents
an
introduction
platform
insight
contribution
cultures.
