Boosting of Enzymatic Cascades by Intermediates: Theoretical Analysis and Model-Based Optimization DOI
Leandros Paschalidis,

Daniela Fröschl,

Manuel Plana

et al.

Published: Jan. 1, 2024

In an earlier work we demonstrated that adding intermediates of enzymatic cascade reaction at the start process can increase space-time yield significantly. This method was coined boosting by (BBI) and potentially productivity systems. BBI remains largely unexplored, its mechanism, potential, limitations are not fully understood. present work, provide a theoretical background studying four chemical networks (CRN) exhibit intermediates. We study dynamics these via quasi steady-state approximation numerical solutions. novel graphical be used to deduce which boost linear, redox neutral networks. Further, demonstrate how such designed using model-based optimization.

Language: Английский

Biocatalytic Hydrogenation of Biomass-Derived Furan Aldehydes to Alcohols DOI
Zhigang Zhang, Xi Shen, Shi‐Kai Jiang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

The biomass-derived furan aldehydes furfural (FF) and 5-hydroxymethylfurfural (HMF) are versatile platform chemicals used to produce various value-added through further valorization processes. Selectively reducing C═O in FF HMF molecules form furfuryl alcohol (FAL) 2,5-bis(hydroxymethyl)furan (BHMF), represents an important research field upgrading biomass-based compounds. Currently, the reduction of alcohols chemical transformation often leads unavoidable environmental issues formation potential byproducts. Biocatalysis has demonstrated expanded applications converting into a diverse array chemicals. This process exhibits significant organic synthesis biotechnology due its green sustainable properties. biocatalytic especially route for selective FAL BHMF. review discusses recent progress biosynthesis BHMF from Recently discovered enzymes whole cells as biocatalysts production summarized. In addition, chemoenzymatic cascades synthesizing biomass hydrolysate raw materials also discussed.

Language: Английский

Citations

1
Primary and secondary waste in (bio)catalysis: What matters is not what is produced, but what permanently remains! DOI
Pablo Domı́nguez de Marı́a

Current Opinion in Green and Sustainable Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 101003 - 101003

Published: Feb. 1, 2025

Language: Английский

Citations

0
Boosting of Enzymatic Cascades by Intermediates: Theoretical Analysis and Model-Based Optimization DOI
Leandros Paschalidis,

Daniela Fröschl,

Manuel Plana

et al.

Published: Jan. 1, 2024

In an earlier work we demonstrated that adding intermediates of enzymatic cascade reaction at the start process can increase space-time yield significantly. This method was coined boosting by (BBI) and potentially productivity systems. BBI remains largely unexplored, its mechanism, potential, limitations are not fully understood. present work, provide a theoretical background studying four chemical networks (CRN) exhibit intermediates. We study dynamics these via quasi steady-state approximation numerical solutions. novel graphical be used to deduce which boost linear, redox neutral networks. Further, demonstrate how such designed using model-based optimization.

Language: Английский

Citations

0