ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(47), P. 46891 - 46903
Published: Nov. 11, 2024
In
the
field
of
contemporary
medicine,
with
rapid
application
nanomaterials,
evaluating
their
biocompatibility
and
potential
toxicity
has
become
increasingly
important.
This
study
characterized
black
phosphorus
nanosheets
(BPNSs)
employed
both
in
vivo
vitro
models
to
assess
impact
BPNSs
exposure
on
oxidative
stress
pyroptosis
hepatocytes.
We
investigated
hepatotoxicity
this
emerging
nanomaterial
protective
role
melatonin
against
induced
hepatocyte
pyroptosis.
The
results
showed
that
reduced
viability,
morphological
changes,
elevated
expression
pyroptosis-related
proteins,
suggesting
promote
through
ROS-NLRP3-GSDMD
pathway,
thereby
exacerbating
inflammatory
response.
Melatonin,
a
bioactive
substance
anti-inflammatory
antioxidant
properties,
was
found
our
significantly
mitigate
these
adverse
effects.
It
emphasized
regulating
ROS
production
related
pathways,
effectively
protecting
hepatocytes
from
damage.
elucidates
mechanistic
link
between
pyroptosis,
emphasizing
efficacy
as
agent.
offers
new
insights
for
preventing
liver
injury
provides
foundation
safer
strategies.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
38, P. 225 - 257
Published: May 7, 2024
The
number
of
multi-drug-resistant
bacteria
has
increased
over
the
last
few
decades,
which
caused
a
detrimental
impact
on
public
health
worldwide.
In
resolving
antibiotic
resistance
development
among
different
bacterial
communities,
new
antimicrobial
agents
and
nanoparticle-based
strategies
need
to
be
designed
foreseeing
slow
discovery
functioning
antibiotics.
Advanced
research
studies
have
revealed
significant
disinfection
potential
two-dimensional
nanomaterials
(2D
NMs)
severed
as
effective
antibacterial
due
their
unique
physicochemical
properties.
This
review
covers
current
progress
2D
NMs-based
based
an
inclusive
explanation
NMs'
agents,
including
detailed
introduction
each
possible
well-known
mechanism.
properties
NMs
activities
been
deliberated
while
explaining
toxic
effects
discussing
biomedical
significance,
dysbiosis,
cellular
nanotoxicity.
Adding
challenges,
we
also
discussed
major
issues
regarding
quality
availability
nanotoxicity
data.
However,
smart
advancements
are
required
fabricate
biocompatible
exploit
combat
clinically.
BMEMat,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 29, 2024
Abstract
The
emergence
of
multidrug‐resistant
bacteria
poses
a
significant
challenge
in
the
treatment
osteomyelitis,
rendering
traditional
antibiotic
strategies
inadequate
terms
achieving
complete
cure.
In
recent
years,
triggerable
biomaterial‐based,
antibiotic‐free
osteomyelitis
have
rapidly
evolved,
demonstrating
excellent
bactericidal
effects.
Triggerable
biomaterials‐based
theranostics
encompass
physical
signal
response
and
host
immune
modulation
approaches.
These
can
be
effective
against
drug‐resistant
bacteria,
circumventing
gradual
acquisition
resistance
that
often
accompanies
treatment.
Additionally,
inherent
properties
biomaterials
facilitate
precise
imaging
osteomyelitis.
There
is
no
doubt
biomaterial‐mediated,
therapies
are
emerging
as
trend,
which
critically
important
combating
bacteria‐induced
this
review,
we
summarize
latest
advances
from
both
pathogen‐directed
host‐directed
perspectives.
design
regimens
specific
action
mechanisms
biomaterial‐based
nanoplatforms
also
clarified.
Finally,
outline
challenges
faced
by
various
provide
an
outlook
on
prospects
for
synergistic
interactions.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(33), P. 43892 - 43906
Published: July 24, 2024
With
the
swift
evolution
of
multidrug-resistant
bacteria
resulting
from
intense
and
inappropriate
use
antibiotics,
there
is
a
pressing
need
for
innovative
solutions.
In
this
study,
thermosensitive
hydrogel
was
developed
efficient
bacterial
inhibition
promotion
wound
healing.
The
antibacterial
chitosan
(CS)
hydrogel,
cross-linked
with
two-dimensional
photothermal
nanomaterial
black
phosphorus
(BP)
nanosheets
through
electrostatic
interactions,
effectively
encapsulates
sustains
release
angiogenic
drug
deferoxamine
mesylate
(DFO).
This
facilitates
acceleration
re-epithelialization
neovascularization
by
enhancing
cell
migration
proliferation.
Following
near-infrared
(NIR)
treatment,
demonstrates
rapid
eradication
most
common
encountered
in
clinical
settings,
achieved
physical
disruption
membranes
therapies.
Noteworthy
significant
upregulation
IL-19
expression
via
STAT3
signaling
pathways
BP/CS-DFO
full-thickness
model.
results
polarization
anti-inflammatory
M2
macrophage
phenotype,
altering
microenvironment
to
pro-healing
state
extracellular
matrix
deposition
blood
vessel
formation.
conclusion,
shows
immense
promise
as
potential
candidate
healing
antimicrobial
therapy.
Its
design
multifunctional
capabilities
position
it
valuable
asset
combating
antibiotic
resistance
efficiency
Journal of Materials Chemistry B,
Journal Year:
2023,
Volume and Issue:
12(1), P. 158 - 175
Published: Nov. 27, 2023
A
novel
injectable
self-healing
adhesive
hydrogel
with
specific
bacteria
capture
capability
and
inherent
contact
antimicrobial
activity
for
mild
photothermal
therapy
NO
controlled
release
to
synergically
eliminate
biofilm
infections
promote
wound
healing.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(10), P. 11022 - 11036
Published: May 7, 2024
Phosphorus
is
widely
present
in
living
organisms
and
nature
exists
a
variety
of
isomers
with
variable
crystal
structures.
There
are
several
common
phosphorus
monomers
biomedicine,
including
red
(RP),
black
(BLK-P),
violet
(VP),
blue
(BLU-P).
Phosphorus-based
semiconductor
materials
(PSCM)
have
adjustable
band
gaps,
high
photogenerated
carrier
mobility,
efficient
photothermal
conversion
as
well
good
biocompatibility
degradability.
In
addition,
phosphorus,
an
essential
element
for
life-sustaining
activities,
all
cells
the
human
body,
accounting
approximately
1%
body's
total
weight.
Therefore,
phosphorus-based
nanomaterials
extensive
applications
biomedical
field.
This
review
will
clarify
classification,
preparation
methods,
physicochemical
properties,
mechanisms
action,
biomedicine
while
also
offering
new
ideas
their
development
biomedicine.
