Collagenase motors in gelatine-based hydrogels DOI
Nanying Wang, Thaís Floriano Marcelino, Carina Ade

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(20), P. 9935 - 9943

Published: Jan. 1, 2024

Nano/micromotors outperform Brownian motion due to their self-propulsive capabilities and hold promise as carriers for drug delivery across biological barriers such the extracellular matrix. This study employs poly(2-(diethylamino)ethyl methacrylate) polymer brushes enhance collagenase-loading capacity of silica particle-based motors with aim systematically investigate impact gelatine viscosity, motors' size, morphology on propulsion velocity. Notably, 500 nm 1 μm achieve similar speeds high ∼15 s-1 in stiff gelatine-based hydrogels when triggered calcium. Taken together, our findings highlight potential collagenase-based navigating matrix, positioning them promising candidates efficient delivery.

Language: Английский

Micro/Nanorobotics in Environmental Water Governance: Nanoengineering Strategies for Pollution Control DOI Creative Commons

Y. Gan,

Bin Wang, Yuan Lu

et al.

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: April 6, 2025

The significance of micro/nanorobotics in environmental water governance is underscored by the escalating challenge pollution, demanding innovative solutions for efficient and selective pollutant removal. These tiny yet powerful devices, with their ability to detect, capture, degrade pollutants, signify a groundbreaking shift from traditional treatment methods more precise, efficient, sustainable approaches. This review delineates advancements micro/nanorobotics, emphasizing diverse propulsion mechanisms functionalities tailored specific tasks, including degradation microplastics, organic inactivation harmful microorganisms. With focus on integration photocatalytic, magnetic, self‐propelled capabilities, text highlights potential these robots revolutionize processes. Furthermore, it acknowledges challenges faced scalability, cost‐effectiveness, compatibility, urging future research toward developing adaptable, eco‐friendly, robotic systems. not only elucidates current but also charts course where intelligent, dynamically controlled systems become central management, offering crucial insights guiding next wave innovations field.

Language: Английский

Citations

0
Dual-propelled polydopamine@SiO2@Pt micromotor with asymmetrical yolk-mesoporous shell for the enhanced catalytic reduction DOI
Xiujuan Li, Sheng Wang,

Xufu Wang

et al.

Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 35, P. 101916 - 101916

Published: Jan. 1, 2024

Language: Английский

Citations

3
A Clinically Feasible Diagnostic Electrochemical Micronano Motors Biosensor Built on Miniature Swimmer for Multiplex Detection and Grading of Breast Cancer Biomarkers DOI

Ya Zhang,

Xiaofang Liu,

Ying Xu

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: July 19, 2024

Estrogen receptor (ER), progesterone (PR), human epidermal growth factor receptor-2 (HER2), and Ki67 are four crucial biomarkers used in the clinical diagnosis of breast cancer. Accurate detection these is essential for an effective treatment. MOF-based micronano motors (MOFtors) promising various applications, including environmental remediation, targeted nanosurgery, biomarker detection. This paper presents a clinically feasible diagnostic electrochemical motor biosensor, built on miniature swimmer, multiplex grading cancer biomarkers. We designed named MOFtor-MSEM, incorporating aptamers antibodies functionalized SiO2@Co–Fe-MOF, which acts as swimmer solution. The SiO2@Co–Fe-MOF serves body, while complementary double-chain-linked function paddles. In homogeneous solution, when positive voltage applied to working electrode, electrostatic interaction between neutral negatively charged double-linked antibody causes move toward electrode then regress due water resistance. back-and-forth motion propels enabling it target analyte through sensor features automatic "sample-amplifying signal-output" process, achieving simultaneous signal amplification output signals single nanomaterial, significant challenge sensing. biosensor boasts short time 40 min, compared approximately 1 week current tissue testing. Additionally, bioplatform selectively detects HER2, ER, Ki67, PR range 0–1500 pg/mL, with limits 0.01420, 0.03201, 0.01430, 0.01229 respectively.

Language: Английский

Citations

2
Nano/Micromotors for Cancer Diagnosis and Therapy: Innovative Designs to Improve Biocompatibility DOI Creative Commons

Jiahuan Zheng,

Rui Huang, Zhexuan Lin

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 16(1), P. 44 - 44

Published: Dec. 27, 2023

Nano/micromotors are artificial robots at the nano/microscale that capable of transforming energy into mechanical movement. In cancer diagnosis or therapy, such “tiny robots” show great promise for targeted drug delivery, cell removal/killing, and even related biomarker sensing. Yet biocompatibility is still most critical challenge restricts techniques from transitioning laboratory to clinical applications. this review, we emphasize aspect nano/micromotors efforts made by researchers promote their application, mainly including non-toxic fuel propulsion (inorganic catalysts, enzyme, etc.), bio-hybrid designs, ultrasound propulsion, light-triggered magnetic dual and, in particular, cooperative swarm-based strategy increasing therapeutic effects. Future challenges translating real applications potential directions also described.

Language: Английский

Citations

5
Review—Recent Advances of Micro/Nano-Motor-Facilitated Electrochemical Sensor Development DOI Creative Commons
Shirsendu Mitra, Mitali Basak, Bharti Saini

et al.

Journal of The Electrochemical Society, Journal Year: 2024, Volume and Issue: 171(3), P. 037511 - 037511

Published: Feb. 27, 2024

Micro/-nano motors (MNMs) are deployed to perform cutting edge research and development activities that include biomedical engineering, environment monitoring, energy harvesting more. MNMs progressively strives for miniaturization of MNMs, mightier self-propulsion, precision motion, smarter motion control. The last decade published several reports on biosensing applications targeting enhanced specificity, selectivity. Among MNM mediated biosensors, the electrochemical biosensor is most important stake holder. Motion enable active transport, augmented reaction kinetics, better selectivity causing biosensing. This review article explores advanced deploying took place in recent past. Briefly, this covers chronological field with emphasis on, conventional working electrode based sensing, DNA walker modificaitons, real time signal scope sensing intracellular monitoring or drug delivery. Conclusively, considers includes both vitro vivo Additionally, we discuss use electorchemical redox reactions imparting physiological fluids manipulation, targeted delivery,

Language: Английский

Citations

0
Collagenase motors in gelatine-based hydrogels DOI
Nanying Wang, Thaís Floriano Marcelino, Carina Ade

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(20), P. 9935 - 9943

Published: Jan. 1, 2024

Nano/micromotors outperform Brownian motion due to their self-propulsive capabilities and hold promise as carriers for drug delivery across biological barriers such the extracellular matrix. This study employs poly(2-(diethylamino)ethyl methacrylate) polymer brushes enhance collagenase-loading capacity of silica particle-based motors with aim systematically investigate impact gelatine viscosity, motors' size, morphology on propulsion velocity. Notably, 500 nm 1 μm achieve similar speeds high ∼15 s-1 in stiff gelatine-based hydrogels when triggered calcium. Taken together, our findings highlight potential collagenase-based navigating matrix, positioning them promising candidates efficient delivery.

Language: Английский

Citations

0