In
this
study,
we
introduce
a
protein–polymer
bioconjugate
comprising
bovine
serum
albumin
(BSA)
and
lipid-based
thermoresponsive
block
copolymer.
These
amphiphilic
BSA-polymer
conjugates
can
autonomously
be
organized
into
vesicular
compartments
for
codelivery
of
glucose
oxidase
(GOx)
doxorubicin
(DOX),
demonstrating
high
drug
loading
content
remarkable
antitumor
activity
via
synergistic
cancer
therapy
combining
chemo-starvation
strategies.
Through
the
incorporation
hydrophilic
BSA
block,
lower
critical
solution
temperature
(LCST)
bioconjugates
is
tuned
to
around
40
°C,
facilitating
their
targeted
delivery
tumor
cells.
Consequently,
these
smart
present
greater
promise
compared
traditional
vehicles,
particularly
in
realm
anticancer
therapy.
Moreover,
displayed
enhanced
intracellular
fluorescence
intensity
with
increasing
temperature,
attributed
clustering-triggered
emission
nonconventional
chromophore
moieties
within
poly(vinylcaprolactam)
(PNVCL).
The
active
aggregation-induced
(AIE)
characteristic
excellent
biocompatibility
suggest
an
opportunity
further
apply
biosensing
cellular
imaging.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(7), P. 7345 - 7354
Published: April 4, 2024
Starvation
therapy
mediated
by
glucose
oxidase
is
a
widely
used
therapeutic
approach
for
tumor
treatment,
but
it
limited
the
simultaneous
drawbacks
of
weak
efficacy,
nonspecificity,
and
systemic
toxicity.
Thus,
combination
was
to
complement
strategy
anticancer
therapy.
On
basis
starvation
therapy,
we
designed
catalytic
model
nanosheets
with
biological
cascade
enzymes
synergizing
drugs.
In
short,
two
(glucose
horseradish
peroxidase)
are
covalently
immobilized
on
Ti3C2
MXene
nanosheet
enzyme
nanoreactor
formed
electrostatically
adsorbing
positive
charged
DOX.
Finally,
outer
layer
coated
hyaluronic
acid.
By
combining
oxidase-mediated
photothermal
chemotherapy,
have
achieved
effect
"killing
three
birds
one
stone"
dual
stimulation
response
endogenous
exogenous
sources
site.
This
method
not
only
achieves
targeting
cancer
cells
also
improves
toxicity
reduced
efficacy
realizes
synergistic
enhanced
reactions.
It
opens
up
new
path
research
nanomedicine.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 11105 - 11128
Published: Nov. 1, 2024
Ferroptosis
is
a
regulated
form
of
cell
death
characterized
by
iron-dependent
accumulation
associated
lipid
peroxides
(LPO),
which
can
induce
when
certain
level
reached.
However,
the
extremely
complex
tumor
microenvironment
(TME)
has
characteristics
antioxidant,
even
if
it
induces
ferroptosis
cells,
its
killing
effect
on
cells
still
very
limited.
To
solve
this
problem,
we
constructed
novel
nanomaterials
(GOx/EC@Fe
