Bacterial
resistance
to
antibiotics
has
rendered
bacterial
infections
an
escalating
threat
public
health,
prompting
numerous
researchers
strive
towards
the
development
of
novel
antimicrobial
agents.
Designable
ionic
liquids
(ILs)
have
gained
increasing
prominence
in
field
antibacterials.
However,
certain
ILs
exhibit
suboptimal
activity
and
limited
biocompatibility.
In
this
study,
we
synthesized
liquid-derived
carbon
dots
(IL-CDs)
through
vinyl
epoxy
group
reactions,
resulting
enhanced
efficacy
favorable
The
IL-CDs
retain
antibacterial
structure
characteristic
ILs,
including
a
positively
charged
imidazole
long
alkyl
chain.
Moreover,
demonstrate
selective
action
against
Staphylococcus
aureus
(S.
aureus)
while
effectively
inhibiting
S.
biofilm
growth.
Notably,
superior
potency
compared
commercially
available
quaternary
ammonium
salt-based
We
conducted
comprehensive
investigations
into
mechanism
which
primarily
involves
electrostatic
interactions,
hydrophobic
as
well
generation
reactive
oxygen
species
(ROS)
within
bacteria
cells.
vivo
experiments
demonstrated
that
significantly
alleviate
inflammation
expedite
wound
healing
aureus-infected
mice
models;
thus
highlighting
their
potential
therapeutic
candidates
for
diseases
resembling
infection-like
conditions.
Importantly,
our
work
presents
approach
utilizing
IL-based
materials
developing
effective
antibacterials
thereby
offering
new
insights
application
prospects
IL-derived
materials.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 15, 2024
Exploring
effective
antibacterial
approaches
for
targeted
treatment
of
pathogenic
bacterial
infections
with
reduced
drug
resistance
is
great
significance.
Combinational
modality
that
leverages
different
therapeutic
components
can
improve
the
overall
effectiveness
and
minimize
adverse
effects,
thus
displaying
considerable
potential
against
infections.
Herein,
red
blood
cell
membrane
fuses
macrophage
to
develop
hybrid
shell,
which
further
camouflages
around
drug-loaded
liposome
fabricate
biomimetic
(AB@LRM)
precise
therapy.
Specifically,
photoactive
agent
black
phosphorus
quantum
dots
(BPQDs)
classical
antibiotics
amikacin
(AM)
are
loaded
in
AB@LRM
accurately
target
inflammatory
sites
through
guidance
long
residence
capability
membrane,
eventually
exerting
efficacious
activities.
Besides,
due
excellent
photothermal
photodynamic
properties,
BPQDs
act
as
an
efficient
when
exposed
near-infrared
laser
irradiation,
dramatically
increasing
sensitivity
bacteria
antibiotics.
Consequently,
synergistic
sterilizing
effect
produced
by
restricts
resistance.
Upon
shows
superior
anti-inflammatory
properties
models
P.
aeruginosa-infected
pneumonia
wounds.
Hence,
this
light-activatable
nanoplatform
good
biocompatibility
presents
advance
clinical
development
Journal of Materials Chemistry B,
Journal Year:
2023,
Volume and Issue:
12(3), P. 742 - 751
Published: Dec. 11, 2023
A
bio-conjugated
carbon
dot-based
detection
probe
enabled
bimodal
(fluorescence
and
electrochemical)
strategy
for
the
determination
of
prostate
specific
antigen
in
a
blood
serum
sample.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 10, 2024
The
World
Health
Organization
has
warned
that
without
effective
action,
deaths
from
drug-resistant
bacteria
can
exceed
10
million
annually,
making
it
the
leading
cause
of
death.
Conventional
antibiotics
are
becoming
less
due
to
rapid
bacterial
drug
resistance
and
slowed
new
antibiotic
development,
necessitating
strategies.
Recently,
materials
with
catalytic/enzymatic
properties,
known
as
nanozymes,
have
been
developed,
inspired
by
natural
enzymes
essential
for
eradication.
Unlike
recent
literature
reviews
broadly
cover
nanozyme
design
biomedical
applications,
this
review
focuses
on
latest
advancements
in
nanozymes
combating
resistance,
emphasizing
their
design,
structural
characteristics,
applications
combination
therapy,
future
prospects.
This
approach
aims
promote
development
especially
towards
clinical
translation.
Antibiotic-resistant
pathogens
pose
a
significant
global
public
health
challenge,
particularly
in
refractory
infections
associated
with
biofilms.
The
urgent
development
of
innovative,
safe,
and
therapeutically
adaptive
strategies
to
combat
these
resistant
biofilms
is
essential.
We
present
novel,
precise,
controllable
photodynamic
antibacterial
carbon
dot
(B-M-CD)
inspired
by
the
natural
properties
mulberry
leaf
bacterial
targeting
function
boric
acid.
This
photocatalytic
agent
exhibits
good
biocompatibility
utilizes
its
inherent
activities,
along
photoactivated
oxidase-mimicking
activity,
generate
reactive
oxygen
species
for
eradication
methicillin-resistant
Staphylococcus
aureus
(MRSA).
By
leveraging
reversible
covalent
binding
between
boronic
acid
groups
cis-diol
on
surfaces,
we
further
enhance
targeted
activity.
B-M-CDs
effectively
penetrate
extracellular
polymeric
substances
demonstrate
precise
effect,
allowing
localized
delivery
aimed
at
biofilm
inhibition
destruction.
Metabolomic
analyses
reveal
that
disrupt
amino
metabolism,
protein
synthesis,
electron
transport
chain,
energy
metabolism
MRSA.
In
vivo
experiments
confirm
this
photocatalyst
treats
MRSA-induced
wounds
an
efficacy
comparable
vancomycin
while
also
exhibiting
high
biocompatibility.
study
represents
first
photoactivated,
controllable,
carbon-based
nanozyme
derived
from
traditional
Chinese
herb,
leaf,
providing
novel
strategy
designing
intelligent
nanoagents
underscoring
their
potential
as
candidate
therapeutics
conditions
analogous
MRSA
infections.
