Discover Nano,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Sept. 17, 2024
With
the
size
of
aging
population
increasing
worldwide,
effective
diagnosis
and
treatment
neurodegenerative
diseases
(NDDs)
has
become
more
important.
Two-dimensional
(2D)
materials
offer
specific
advantages
for
NDDs
due
to
their
high
sensitivity,
selectivity,
stability,
biocompatibility,
as
well
excellent
physical
chemical
characteristics.
As
such,
2D
a
promising
avenue
development
highly
sensitive,
selective,
biocompatible
theragnostics.
This
review
provides
an
interdisciplinary
overview
advanced
use
in
biosensors,
drug
delivery,
tissue
engineering/regenerative
medicine
and/or
NDDs.
The
material-based
biosensors
enabled
early
detection
monitoring
via
precise
biomarkers
or
biological
changes,
while
delivery
systems
targeted
controlled
release
therapeutics
brain,
crossing
blood-brain
barrier
enhancing
effectiveness.
In
addition,
when
used
engineering
regenerative
medicine,
facilitate
cell
growth,
differentiation,
regeneration
restore
neuronal
functions
repair
damaged
neural
networks.
Overall,
show
great
promise
NDDs,
thus
improving
quality
life
patients
population.
Discover Nano,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Oct. 4, 2024
Nanomedicine
has
the
potential
to
transform
healthcare
by
offering
targeted
therapies,
precise
diagnostics,
and
enhanced
drug
delivery
systems.
The
National
Institutes
of
Health
coined
term
"nanomedicine"
describe
use
nanotechnology
in
biological
system
monitoring,
control,
diagnosis,
treatment.
continues
receive
increasing
interest
for
rationalized
therapeutics
pharmaceutical
agents
achieve
required
response
while
reducing
its
side
effects.
However,
as
advance,
concerns
about
toxicological
effects
have
also
grown.
This
review
explores
current
state
nanomedicine,
focusing
on
types
nanoparticles
used
their
associated
properties
that
contribute
nanotoxicity.
It
examines
mechanisms
through
which
exert
toxicity,
encompassing
various
cellular
molecular
interactions.
Furthermore,
it
discusses
assessment
methods
employed
evaluate
nanotoxicity,
in-vitro
in-vivo
models,
well
emerging
techniques.
addresses
regulatory
issues
surrounding
nanotoxicology,
highlighting
challenges
developing
standardized
guidelines
ensuring
secure
translation
nanomedicine
into
clinical
settings.
ethical
with
understanding
safety
profile
is
essential
effective
therapeutic
applications.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(15), P. 17295 - 17304
Published: July 15, 2024
In
this
work,
we
report
the
synthesis
of
cerium
vanadate
(CeVO4)
nanoparticles
and
their
application
in
modifying
screen-printed
carbon
electrodes
(SPCEs)
for
electrochemical
detection
chloramphenicol
(CPC).
The
physicochemical
properties
CeVO4
were
thoroughly
investigated
by
using
X-ray
diffraction
(XRD),
Raman
spectroscopy,
photoelectron
spectroscopy
(XPS),
transmission
electron
microscopy
(TEM),
confirming
crystallinity
nanostructure.
Electrochemical
assays
demonstrated
that
CeVO4-modified
SPCE
exhibited
significantly
enhanced
electrocatalytic
performance
toward
CPC,
as
evidenced
increased
peak
currents
decreased
charge-transfer
resistance.
A
series
experiments
involving
cyclic
voltammetry
differential
pulse
established
a
diffusion-controlled
mechanism
CPC
redox
reactions
on
modified
electrode
surface.
sensor
showed
wide
linear
range
(0.01–550
μM)
limit
(0.002
was
lower
than
bare
SPCE.
Furthermore,
displayed
excellent
selectivity
presence
potential
interfering
substances,
remarkable
stability
over
repeated
cycling,
consistent
reproducibility,
highlighting
robustness
CeVO4/SPCE
sensing
platform.
integration
into
SPCEs
presents
significant
advancement
development
sensitive
sensors
with
implications
environmental
monitoring,
food
safety
assessment,
clinical
diagnostics.
Discover Nano,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: Jan. 16, 2025
Abstract
Phytonanoparticles
have
emerged
as
a
promising
class
of
biomaterials
for
enhancing
bone
regeneration
and
osseointegration,
offering
unique
advantages
in
biocompatibility,
multifunctionality,
sustainability.
This
comprehensive
review
explores
the
synthesis,
characterization,
applications
phytonanoparticles
tissue
engineering.
The
green
synthesis
approach,
utilizing
plant
extracts
reducing
stabilizing
agents,
yields
nanoparticles
with
intrinsic
bioactive
properties
that
can
synergistically
promote
osteogenesis.
We
examine
mechanisms
by
which
phytonanoparticles,
particularly
those
derived
from
gold,
silver,
zinc
oxide,
influence
key
molecular
pathways
osteogenesis,
including
RUNX2
Osterix
signaling.
discusses
advanced
strategies
phyto-nanoparticle
design,
such
surface
functionalization
stimuli-responsive
release
mechanisms,
enhance
their
efficacy
applications.
Preclinical
studies
demonstrating
improved
osteoblast
proliferation,
differentiation,
mineralization
are
critically
analyzed,
along
emerging
clinical
data.
Despite
results,
scalability,
standardization,
regulatory
approval
challenges
persist.
also
addresses
economic
environmental
implications
production.
Looking
ahead,
we
identify
research
directions,
developing
personalized
therapies,
combination
approaches
stem
cells
or
gene
delivery,
long-term
safety
assessments.
By
harnessing
power
plant-derived
nanomaterials,
represent
an
innovative
approach
to
addressing
complex
regeneration,
potential
spanning
dental,
orthopedic,
maxillofacial
surgery.
Graphical
abstract
Biomarker Research,
Journal Year:
2024,
Volume and Issue:
12(1)
Published: Nov. 13, 2024
Lung
cancer
leads
in
causing
cancer-related
mortality
worldwide,
continually
posing
a
significant
threat
to
human
health.
Current
imaging
diagnostic
techniques,
while
offering
non-invasive
detection,
suffer
from
issues
such
as
insufficient
sensitivity
and
the
risks
associated
with
radiation
exposure.
Pathological
diagnosis,
gold
standard
for
confirmation,
also
faces
challenges
like
invasiveness
high
costs.
In
treatment,
surgery,
radiotherapy,
chemotherapy
are
main
modalities,
each
encountering
related
precision,
environmental
adaptability,
side
effects.
Nanotechnology's
advancement
provides
new
solutions
diagnosis
treatment
of
lung
cancer,
promising
enhance
accuracy
reduce
effects
during
treatment.
This
article
introduces
types
nanomaterials
used
field
comprehensive
overview
current
research
on
application
nanotechnology
early
screening,
monitoring
summarizing
ongoing
clinical
findings.
