Advancements in hydrogel design for articular cartilage regeneration: A comprehensive review

Bioactive Materials, Journal Year: 2024, Volume and Issue: 43, P. 1 - 31

Published: Sept. 14, 2024

Language: Английский

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Engineering complex tissue-like microenvironments with biomaterials and biofabrication

Trends in biotechnology, Journal Year: 2024, Volume and Issue: 42(10), P. 1241 - 1257

Published: April 23, 2024

Advances in tissue engineering for both system modeling and organ regeneration depend on embracing recapitulating the target tissue's functional structural complexity. Microenvironmental features such as anisotropy, heterogeneity, other biochemical mechanical spatiotemporal cues are essential regulating development function. Novel biofabrication strategies innovative biomaterial design have emerged promising tools to better reproduce features. These facilitate a transition towards high-fidelity biomimetic structures, offering opportunities deeper understanding of function superior therapies. In this review, we explore some key compositional aspects tissues, lay out how achieve similar outcomes with current fabrication strategies, identify main challenges avenues future research.

Language: Английский

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Bio-inspired mineralized collagen scaffolds with precisely controlled gradients for the treatment of severe osteoarthritis in a male rabbit model

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139843 - 139843

Published: Jan. 1, 2025

Language: Английский

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Innovative modification strategies and emerging applications of natural hydrogel scaffolds for osteoporotic bone defect regeneration

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 28, 2025

Osteoporosis, a prevalent systemic metabolic bone disease, is characterized by diminished mass, microarchitectural deterioration of tissue, and heightened fragility. In osteoporotic patients, chronic progressive loss often leads to fractures and, in advanced cases, critical-sized defects. While traditional repair approaches are constrained significant limitations, the advent bioactive scaffolds has transformed therapeutic paradigm for regeneration. Among these innovations, natural polymer-based hydrogel have emerged as particularly promising solution tissue engineering, owing their superior biocompatibility, tunable biodegradation properties, exceptional ability replicate native extracellular matrix environment. This review systematically explores recent breakthroughs modification techniques applications defect repair, while critically analyzing existing clinical challenges proposing future research trajectories this rapidly evolving field.

Language: Английский

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Current status of research on polysaccharide-based functional gradient gel materials: A review

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 344, P. 122520 - 122520

Published: July 22, 2024

Language: Английский

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Enhanced fibrocartilage regeneration at the tendon-bone interface injury through extracellular matrix hydrogel laden with bFGF-overexpressing human urine-derived stem cells

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154333 - 154333

Published: July 27, 2024

Language: Английский

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