Self-assembled nanoparticles of costunolide and glycyrrhizic acid for enhanced ulcerative colitis treatment DOI Creative Commons
Hao Fu, Xiao Zheng, Ke Xu

et al.

BMC Gastroenterology, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 11, 2024

Abstract Ulcerative colitis (UC) is a persistent inflammatory condition that specifically targets the colon and rectum. Existing therapies fail to adequately address clinical requirements of people suffering from this ailment. Despite acknowledged potential nanomedicines in field anti-inflammatory treatment, their widespread use settings impeded by expensive nature uncertainty surrounding safety profiles. This study illustrates two naturally occurring phytochemicals, Costunolide (COS) Glycyrrhizic acid (GA), form carrier-free, multifunctional spherical nanoparticles (NPs) through noncovalent interactions, such as π–π stacking hydrogen bonding. The COS-GA NPs displayed synergistic effect, providing much more evidently improved therapeutic benefits for dextran sodium sulfate (DSS)-induced UC mice due effective reduction inflammation oxidative stress than did equal dosages COS or GA used alone. In addition, have biocompatibility biosafety properties unique them. will serve affirmation innovative natural antioxidant activities also agents drug discovery UC, leading possibly better outcomes living with disabling condition.

Language: Английский

Nanosuspension Innovations: Expanding Horizons in Drug Delivery Techniques DOI Creative Commons
Shery Jacob, Fathima Sheik Kather, Sai H. S. Boddu

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 136 - 136

Published: Jan. 19, 2025

Nanosuspensions (NS), with their submicron particle sizes and unique physicochemical properties, provide a versatile solution for enhancing the administration of medications that are not highly soluble in water or lipids. This review highlights recent advancements, future prospects, challenges NS-based drug delivery, particularly oral, ocular, transdermal, pulmonary, parenteral routes. The conversion oral NS into powders, pellets, granules, tablets, capsules, incorporation film dosage forms to address stability concerns is thoroughly reviewed. article summarizes key stabilizers, polymers, surfactants, excipients used formulations, along ongoing clinical trials patents. Furthermore, comprehensive analysis various methods preparation provided. also explores vitro vivo characterization techniques, as well scale-down technologies bottom-up preparation. Selected examples commercial products discussed. Rapid advances field could resolve issues related permeability-limited absorption hepatic first-pass metabolism, offering promise based on proteins peptides. evolution novel stabilizers essential overcome current limitations stability, bioavailability, targeting ability, safety profile, which ultimately accelerates application commercialization.

Language: Английский

Citations

4
NLRP3 inflammasome promotes functional repair after spinal cord injury in mice by regulating autophagy and its mechanism DOI
Haozhe Tian, Juan Zheng, Fangli Wang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 149, P. 114230 - 114230

Published: Feb. 7, 2025

Language: Английский

Citations

1
Shengjiang Xiexin Decoction ameliorates DSS-induced ulcerative colitis via activating Wnt/β-Catenin signaling to enhance epithelium renovation and modulating intestinal flora DOI
Chen Chen, Xiaohu Lin, Yimin Xie

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156456 - 156456

Published: Feb. 1, 2025

Language: Английский

Citations

0
Piperine inhibits fungal growth and protects against pyroptosis in Aspergillus fumigatus keratitis by regulating the mTOR/HIF-1α pathway DOI

Hong Li,

Bing Yu, Jing Lin

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 150, P. 114286 - 114286

Published: Feb. 15, 2025

Language: Английский

Citations

0
Natural Alkaloids Modulating Macrophage Polarization: Innovative Therapeutic Strategies for Inflammatory, Cardiovascular, and Cancerous Diseases DOI
Jing Lü, Minghao Yin, Yixuan Song

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156709 - 156709

Published: April 1, 2025

Language: Английский

Citations

0
Self-assembled nanoparticles of costunolide and glycyrrhizic acid for enhanced ulcerative colitis treatment DOI Creative Commons
Hao Fu, Xiao Zheng, Ke Xu

et al.

BMC Gastroenterology, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 11, 2024

Abstract Ulcerative colitis (UC) is a persistent inflammatory condition that specifically targets the colon and rectum. Existing therapies fail to adequately address clinical requirements of people suffering from this ailment. Despite acknowledged potential nanomedicines in field anti-inflammatory treatment, their widespread use settings impeded by expensive nature uncertainty surrounding safety profiles. This study illustrates two naturally occurring phytochemicals, Costunolide (COS) Glycyrrhizic acid (GA), form carrier-free, multifunctional spherical nanoparticles (NPs) through noncovalent interactions, such as π–π stacking hydrogen bonding. The COS-GA NPs displayed synergistic effect, providing much more evidently improved therapeutic benefits for dextran sodium sulfate (DSS)-induced UC mice due effective reduction inflammation oxidative stress than did equal dosages COS or GA used alone. In addition, have biocompatibility biosafety properties unique them. will serve affirmation innovative natural antioxidant activities also agents drug discovery UC, leading possibly better outcomes living with disabling condition.

Language: Английский

Citations

1