Direct and indirect approaches to red-shift photoactivated nitric oxide release

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 515, P. 215921 - 215921

Published: May 21, 2024

Nitric oxide (NO) is an important biochemical molecule that endogenously produced to act for instance as neurotransmitter, effect cell growth, or regulate the immune response. Therapeutic treatment with exogeneous NO difficult owing its gaseous and reactive nature and, not surprising, specific molecules deliver have been developed. Amongst various triggers deliberately release from these NO-releasing molecules, light most elegant allows a high degree of control over time location NO-release. For therapeutic applications, it necessary use long-wavelength light, preferably in red near infrared region, which challenging achieve. This review gives overview on approaches red-shift activation wavelength light-activated NO-release nitrosoamines, o-substituted nitroarenes, L-arginine, cupferron, nitrosyl metal complexes. While focusing single photon excitation events, direct mechanisms are covered well photoelectron transfer, energy chemiluminescence photothermal light-triggered oxidation pathways. each NO-releaser class, photochemical mechanism discussed, biological applications mentioned.

Language: Английский

Breaking Barriers in Oncology: Harnessing Sonodynamic Therapy for Enhanced Tumor Metabolism Regulation

Small, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Abstract The recent booming development of sonometabolism regulation in controlling the tumor microenvironment (TME) has opened a new research area to identify innovative approaches against cancer. aim this review is highlight potentials and advantages sonodynamic therapy (SDT) antitumor nanotherapies, specifically, delineating progress made SDT concerning TME metabolism which encompasses factors such as hypoxia, redox balance, autophagy, immunosuppression, ion homeostasis, other metabolic processes. By focusing on both cell dynamics, wide range strategies that have demonstrated great therapeutic effectiveness by targeting functions inherent are summarized. In conclusion, offers valuable insights for researchers involved SDT‐based strategies, with advancing methodologies future research.

Language: Английский

Blood Cell Membrane-Coated Nanomaterials as a Versatile Biomimetic Nanoplatform for Antitumor Applications

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(21), P. 1757 - 1757

Published: Oct. 31, 2024

The application of nanomaterials in tumor therapy is increasingly widespread, offering more possibilities for enhanced therapy. However, the unclear biological distribution and metabolism may lead to immune rejection or inflammatory reactions, posing numerous challenges their clinical translation. rich diversity multifaceted functions blood cells offer promising avenues enhancing nanoparticles cancer Blood cell membranes, being made naturally found components body, exhibit significant biocompatibility, which can reduce body’s response, extend drug’s residence time bloodstream, enhance its bioavailability. Integrating membranes with enhances by improving targeted delivery, prolonging circulation time, evading responses. This review summarizes recent advancements membrane-coated antitumor therapy, a particular focus on use photodynamic photothermal treatments. Additionally, it explores potential synergistic effects when combined other therapeutic modalities.

Language: Английский