International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 12957 - 12973
Published: Dec. 1, 2024
As
a
type
of
transdermal
drug
delivery
system
(TDDS),
Microneedles
(MNs)
have
garnered
significant
attention
from
researchers
due
to
their
ability
penetrate
the
stratum
corneum
(SC)
skin,
enhance
permeability
and
bioavailability,
avoid
first-pass
metabolism,
cause
minimal
damage
skin.
This
makes
them
particularly
suitable
for
localized
delivery.
Dissolvable
microneedles
(DMNs)
can
encapsulate
sensitive
particles,
provide
high
drug-loading
capacity,
possess
biodegradability
biocompatibility,
attracting
extensive
research
interest.
Chitosan
(CS)
has
been
selected
as
matrix
manufacturing
DMNs
its
excellent
properties,
including
not
eliciting
an
immune
response
in
vivo
having
active
functional
groups
such
hydroxyl
amino
that
allow
modifications
impart
appropriate
mechanical
strength
functionality
specific
applications.
paper
provides
comprehensive
review
status
various
chitosan-based
(CSMNs),
explores
mechanisms
dissolution
vivo,
discusses
applications
promoting
wound
healing,
delivering
macromolecular
drugs,
vaccine
delivery,
anti-tumor
therapies.
