A Label-Free Photoelectrochemical Biosensor Based on ZnO/Cs3MnBr5 Heterogeneous Films for Alpha-Fetoprotein Detection DOI Creative Commons

Long Shao,

Zhang Biyu, Wei Wu

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(13), P. 1127 - 1127

Published: June 29, 2024

Highly sensitive and specific biomarker detection is of outstanding importance for the diagnosis treatment cancers. Herein, we developed robust photoelectrochemical (PEC) biosensors with low background noise high sensitivity based on a heterojunction, which can improve semiconductor photoelectric properties by limiting recombination photogenerated electron–hole pairs successfully widening range light absorption. Alpha-fetoprotein (AFP) was used as target model to examine analytical performances designed PEC biosensors. ZnO/Cs3MnBr5 heterogeneous film uniform porous structure large surface area enhanced electron transfer biomolecule immobilization, significantly increased photocurrent response. Under optimal conditions, biosensor exhibited linear 0.01–500 ng/mL limit 12 pg/mL. In addition, this performed well when testing human serum samples good repeatability, stability over time, specificity, showing enormous potential cancer markers in future biological clinical research.

Language: Английский

Exponential amplification reaction assisted CRISPR/Cas12a target-induced polarity switching photoelectrochemical biosensor for miRNA-622 detection DOI
Lina Zhang, Lu Zhang, Dandan Liu

et al.

Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137723 - 137723

Published: March 1, 2025

Language: Английский

Citations

0
A Label-Free Photoelectrochemical Biosensor Based on ZnO/Cs3MnBr5 Heterogeneous Films for Alpha-Fetoprotein Detection DOI Creative Commons

Long Shao,

Zhang Biyu, Wei Wu

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(13), P. 1127 - 1127

Published: June 29, 2024

Highly sensitive and specific biomarker detection is of outstanding importance for the diagnosis treatment cancers. Herein, we developed robust photoelectrochemical (PEC) biosensors with low background noise high sensitivity based on a heterojunction, which can improve semiconductor photoelectric properties by limiting recombination photogenerated electron–hole pairs successfully widening range light absorption. Alpha-fetoprotein (AFP) was used as target model to examine analytical performances designed PEC biosensors. ZnO/Cs3MnBr5 heterogeneous film uniform porous structure large surface area enhanced electron transfer biomolecule immobilization, significantly increased photocurrent response. Under optimal conditions, biosensor exhibited linear 0.01–500 ng/mL limit 12 pg/mL. In addition, this performed well when testing human serum samples good repeatability, stability over time, specificity, showing enormous potential cancer markers in future biological clinical research.

Language: Английский

Citations

0