One-Pot Synthesis of Tumor-Targeted Gold-Doped Cu1.92S Plasmonic Nanodots for Enhanced NIR-Triggered, pH-Responsive PTT/PDT/CDT DOI
Neha Mehrotra, Kaushik Pal

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 17(1), P. 408 - 418

Published: Dec. 25, 2024

Copper-based sulfides are attractive candidates for NIR I and II responsive photothermal therapy but often suffer from high hydrophobicity, suboptimal conversion, poor biostability biocompatibility. In the present work, a rapid, one-pot synthesis method was developed to obtain Au-doped Cu1.92S (ACSH NDs) dual plasmonic nanodots. ACSH NDs exhibit excellent peroxidase-like catalytic activity pH-responsive •OH radical generation along with efficient glutathione depletion under tumor microenvironment mimicking conditions. Upon exposure NIR-I laser light, demonstrate conversion efficiency of 47.44% as well significant photodynamic effect through singlet oxygen generation. The in situ hyaluronic acid capping endows nanodots highly selective uptake breast cancer cells both vitro vivo. Simultaneous chemodynamic NIR-triggered photothermal/photodynamic activities result synergistic cell death 98% inhibition single-dose mouse model study. Therefore, show remarkable potential single nanoplatform-actuated drug-free multimodal therapy.

Language: Английский

Microneedle-based nanodrugs for tumor immunotherapy DOI

Tianye Wang,

Hongyu Liu, Meng Li

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 539 - 562

Published: Feb. 13, 2025

Language: Английский

Citations

0
Mechanisms and Applications of Manganese-Based Nanomaterials in Tumor Diagnosis and Therapy DOI Creative Commons
Xiaowen Ma, Chuan He, Yang Wang

et al.

Biomaterials Research, Journal Year: 2025, Volume and Issue: 29

Published: Jan. 1, 2025

Tumors are the second most common cause of mortality globally, ranking just below heart disease. With continuous advances in diagnostic technology and treatment approaches, survival rates some cancers have increased. Nevertheless, due to complexity mechanisms underlying tumors, cancer remains a serious public health issue that threatens population globally. Manganese (Mn) is an essential trace element for human body. Its regulatory role tumor biology has received much attention recent years. Developments nanotechnology led emergence Mn-based nanoparticles great potential use diagnosis cancers. nanomaterials can be integrated with conventional techniques, including chemotherapy, radiation therapy, gene augment their therapeutic effectiveness. Further, play synergistic emerging strategies such as immunotherapy, photothermal photodynamic electromagnetic hyperthermia, sonodynamic chemodynamic intervention therapy. Moreover, enhance both precision diagnostics capability combined treatment. This article examines roles associated Mn field physiology biology, focus on application prospects

Language: Английский

Citations

0
Biomimetic gold nano-modulator for deep-tumor NIR-II photothermal immunotherapy via gaseous microenvironment remodeling strategy DOI Creative Commons

Honglin Huang,

Zhengxin Xie,

Ningxi Li

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 18, 2025

Effective immunotherapeutic treatment of solid tumors has been greatly challenged by the complex hostile tumor immunosuppressive microenvironment (TIME), which typically involves hypoxia and immunosuppression. Herein, a multifunctional biomimetic gold nano-modulator (denoted as GNR-SNO@MMT) was developed to realize efficient second near-infrared (NIR-II) photothermal immunotherapy via targeting deep penetration, vascular normalization immune reprogramming. NIR-II agent nanorods (GNR) were grafted with thermosensitive S-nitrosothiol (SNO) donors camouflaged tumor-penetrating peptide tLyp-1-modified macrophage membrane (MM) yield GNR-SNO@MMT. The engineered coating increased capacity for inflammatory tropism aided GNR-SNO@MMT in ablating together laser irradiation. Moreover, hyperthermia-stimulated nitric oxide (NO) release situ acted gas immunomodulator effectively enhance blood perfusion reprogram TIME multiple functions (e.g., decreasing PD-L1, repolarizing tumor-associated macrophages, revitalizing cytotoxic T cells). Ultimately, inhibition rate against 4T1 mouse mammary model mediated plus 94.7% 2.4-fold CD8+ cells infiltrated into than that untreated counterpart. provides an effective novel photoimmunotherapy candidate deep-sited through reconfiguration NO-involved nanomedicine external assistance.

Language: Английский

Citations

0
The role of manganese-based MRI contrast agents for cancer theranostics: Where do we stand in 2025? DOI Creative Commons
Lingyan Zhang,

Shubham Roy,

Bing Guo

et al.

Theranostics, Journal Year: 2025, Volume and Issue: 15(9), P. 4147 - 4174

Published: March 15, 2025

Magnetic resonance imaging (MRI) guidance in the realm of anticancer therapy is crucial to visualize spread tumors deep tissues, accumulate therapeutics, and trigger them for precise therapy. Recent studies bridge this gap by integrating MRI contrast agents (CAs) with different therapeutic regimes a better outcome. In context, manganese-based materials hold great potential owing their T1/T2 dual-modal MR-relaxation, less toxicity, other capabilities such as chemodynamic therapy, immunotherapy, etc., which have gained increasing interest among researchers medical professionals. This work offers timely update on last three years Mn-based MRI-guided theranostic applications, including chemotherapy, photo therapies, sonodynamic radiotherapy against cancer. Further, several combinatory therapies surgical intersections also been summarized light guidance. The design rationale these has discussed understand existing challenges plausible outcomes shortly. Herein, we dive into stimulus-based probes pH, temperature, etc. show unexplored Mn-complexes domain. state-of-the-art review will guide innovations CAs expedite safer modules clinical translation.

Language: Английский

Citations

0
A Chiral Amino Acid-Modified pH-Responsive Nanoplatform Coactivates Cuproptosis and cGAS-STING Signaling Pathways for Cancer Therapy DOI

Lin Li,

G H Wang,

Benchu Xue

et al.

ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1973 - 1983

Published: April 21, 2025

Language: Английский

Citations

0
Green low-melting mixture solvents- and ionic liquids-based carbon materials and lithium-ion batteries recycling leachate unexpectedly cause water pollution from dissolved organic matter DOI
Chong Liu, X. Han, Qi Zhang

et al.

Journal of the Indian Chemical Society, Journal Year: 2024, Volume and Issue: unknown, P. 101458 - 101458

Published: Nov. 1, 2024

Language: Английский

Citations

1
One-Pot Synthesis of Tumor-Targeted Gold-Doped Cu1.92S Plasmonic Nanodots for Enhanced NIR-Triggered, pH-Responsive PTT/PDT/CDT DOI
Neha Mehrotra, Kaushik Pal

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 17(1), P. 408 - 418

Published: Dec. 25, 2024

Copper-based sulfides are attractive candidates for NIR I and II responsive photothermal therapy but often suffer from high hydrophobicity, suboptimal conversion, poor biostability biocompatibility. In the present work, a rapid, one-pot synthesis method was developed to obtain Au-doped Cu1.92S (ACSH NDs) dual plasmonic nanodots. ACSH NDs exhibit excellent peroxidase-like catalytic activity pH-responsive •OH radical generation along with efficient glutathione depletion under tumor microenvironment mimicking conditions. Upon exposure NIR-I laser light, demonstrate conversion efficiency of 47.44% as well significant photodynamic effect through singlet oxygen generation. The in situ hyaluronic acid capping endows nanodots highly selective uptake breast cancer cells both vitro vivo. Simultaneous chemodynamic NIR-triggered photothermal/photodynamic activities result synergistic cell death 98% inhibition single-dose mouse model study. Therefore, show remarkable potential single nanoplatform-actuated drug-free multimodal therapy.

Language: Английский

Citations

0