Multifunctional Calix[4]Pyrrole Derivatives: Optimized Synthesis and a Dual-Action Study Targeting Tuberculosis and Oxidative Stress DOI
Nirali Parmar, Keyur Bhatt, Jaymin Parikh

et al.

Polycyclic aromatic compounds, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 11

Published: Dec. 24, 2024

The ongoing challenge of multidrug-resistant Mycobacterium tuberculosis underscores the urgent need for new therapeutic agents that address both (TB) and associated oxidative stress. This study explores synthesis bioactivity six novel calix[4]pyrrole derivatives fused with amino acids, using an optimized HATU DIPEA-mediated coupling method to enhance yield stability. These were subsequently assessed their antitubercular antioxidant activities. By incorporating particularly aromatic ones, into framework, aims investigate potential as dual-function candidates managing TB stress-related complications.

Language: Английский

A unimolecular artificial cation channel based on cascaded hydrated acid groups DOI
Pengyang Xin, Hailong Yuan, Long Zhang

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(42), P. 10835 - 10838

Published: Jan. 1, 2024

Based on the cascade dehydration concept, an amphiphilic unimolecular cation channel was synthesized by attaching multiple carboxyl groups to both sides of hybrid molecule, resulting in excellent transport activity and pH-modulated properties.

Language: Английский

Citations

0
Multifunctional Calix[4]Pyrrole Derivatives: Optimized Synthesis and a Dual-Action Study Targeting Tuberculosis and Oxidative Stress DOI
Nirali Parmar, Keyur Bhatt, Jaymin Parikh

et al.

Polycyclic aromatic compounds, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 11

Published: Dec. 24, 2024

The ongoing challenge of multidrug-resistant Mycobacterium tuberculosis underscores the urgent need for new therapeutic agents that address both (TB) and associated oxidative stress. This study explores synthesis bioactivity six novel calix[4]pyrrole derivatives fused with amino acids, using an optimized HATU DIPEA-mediated coupling method to enhance yield stability. These were subsequently assessed their antitubercular antioxidant activities. By incorporating particularly aromatic ones, into framework, aims investigate potential as dual-function candidates managing TB stress-related complications.

Language: Английский

Citations

0