Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
This review discusses phototherapeutic nanosystems for oral cancer, emphasizing diverse drug delivery systems, advanced photodynamic therapy approaches, and combination therapies.
Language: Английский
Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)
Published: Oct. 31, 2024
Copper is an important trace element for maintaining key biological functions such as cellular respiration, nerve conduction, and antioxidant defense. Maintaining copper homeostasis critical human health, its imbalance has been linked to various diseases, especially cancer. Cuproptosis, a novel mechanism of copper-induced cell death, provides new therapeutic opportunities metal ion regulation interact with fate. This review insights into the complex mechanisms metabolism, molecular basis cuproptosis, association cancer development. We assess role cuproptosis-related genes (CRGs) associated tumorigenesis, their importance prognostic indicators targets, impact on tumor microenvironment (TME) immune response. Ultimately, this highlights interplay between copper, immunotherapy.
Language: Английский
Citations
2
RSC Advances, Journal Year: 2024, Volume and Issue: 14(19), P. 13180 - 13189
Published: Jan. 1, 2024
Disulfiram (DSF) can target and kill cancer cells by disrupting cellular degradation of extruded proteins has therefore received particular attention for its tumor chemotherapeutic potential.
Language: Английский
Citations
2
JACS Au, Journal Year: 2024, Volume and Issue: 4(10), P. 3988 - 3999
Published: Sept. 20, 2024
Copper-mediated programmed cell death, which influences the regulation of tumor progression, is an effective approach for antitumor molecular therapy. Unlike apoptosis, copper complex-induced cuproptosis by lipid-acylated protein aggregation triggers mitochondrial proteotoxic stress response, could be associated with immunomodulation. However, it remains a great challenge to understand distinctive mechanisms that presumably activate immunity cuproptosis. Here, new nonlabeling fluorescent tools Cu-DPPZ-Py
Language: Английский
Citations
2
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: July 22, 2024
Mitochondrial damage contributes to apoptosis, oxidative stress, and inflammation, which collectively impact the immune system's function tumor microenvironment (TME). These processes, in turn, influence cell growth, migration, response treatment. We conducted a bibliometric analysis elucidate complex interactions between mitochondrial damage, system, TME. Data were sourced from Science Citation Index Core Collection (WoSCC) analyzed using advanced tools like VOSviewer Citespace. Our focus was on literature published 1999 2023 concerning TME, as well responses tumors. The included regional contributions, journal influence, institutional collaborations, authorship, co-cited authors, keyword citation bursts. research encompassed 2,039 publications, revealing an increasing trend annual output exploring relationship TME dynamics, responses. China, United States, South Korea emerged leading contributors. Prominent institutions Institut National de la Santé et Recherche Médicale, University of Texas System, China Medical University, Sun Yat-sen University. Key journals this field are International Journal Molecular Sciences, Mitochondrion, European Pharmacology. Liang H Wallace DC identified most productive respectively. Keyword highlighted critical roles inflammatory responses, system recent research. This provides comprehensive overview historical current trends, underscoring pivotal role system.
Language: Английский
Citations
1
Cancer Pathogenesis and Therapy, Journal Year: 2024, Volume and Issue: unknown
Published: July 1, 2024
Copper (Cu) is an indispensable micronutrient that maintains signaling pathways and biological homeostasis in almost all cell types; however, its excess affects the tricarboxylic acid cycle, causes accumulation of fatty acylated proteins, destabilization iron–sulfur cluster increases levels intracellular reactive oxygen species, leading to proteotoxic stress death. Cuproptosis, a form Cu-dependent death, differs from other types regulated death (RCD) was first reported Science 2022. Recently, RCD have been targeted cancer therapy. However, escape apoptosis tumor cells resistance treatment recurrence. Therefore, there urgent need study alternative mechanisms mortality. Compared normal patients, significant increase serum Cu ion has observed patients with tumors. Moreover, proliferation, angiogenesis, metastasis are associated cuproptosis. Thus, exploring related cuproptosis will provide new perspective for development anti-cancer drugs. Importantly, closely modulation anti-tumor immunity. The expression cuproptosis-related genes (CRGs) significantly correlated immune infiltration checkpoint programmed protein 1 (PD-1)/programmed death-ligand (PD-L1). Based on these findings, series drugs used tumor-targeted combination therapy or as synergists. elucidating role per stage microenvironment (TIME) helpful clarifying potential value specific cancers. In this review, we summarize based regulation concentration. two approaches may help researchers develop more therapies targeting pathways. focused effect TIME systematically discussed CRGs immunity considering CRG-related pathways, prognosis scoring system, immunotherapy, experiments bioinformatics prediction models, ideas anticancer
Language: Английский
Citations
0
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
This review discusses phototherapeutic nanosystems for oral cancer, emphasizing diverse drug delivery systems, advanced photodynamic therapy approaches, and combination therapies.
Language: Английский
Citations
0