Advancements in zinc oxide nanomaterials: Synthesis, properties, and diverse applications

Nano-Structures & Nano-Objects, Journal Year: 2024, Volume and Issue: 39, P. 101271 - 101271

Published: July 24, 2024

Language: Английский

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New Perspectives of Hydrogels in Chronic Wound Management

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 686 - 686

Published: Feb. 4, 2025

Chronic wounds pose a substantial healthcare concern due to their prevalence and cost burden. This paper presents detailed overview of chronic emphasizes the critical need for novel therapeutic solutions. The pathophysiology wound healing is discussed, including stages factors contributing chronicity. focus on diverse types wounds, such as diabetic foot necrosis, pressure ulcers, venous leg highlighting etiology, consequences, issues they provide. Further, modern care solutions, particularly hydrogels, are highlighted tackling challenges management. Hydrogels characterized multipurpose materials that possess vital characteristics like capacity retain moisture, biocompatibility, incorporation active drugs. Hydrogels’ effectiveness in applications demonstrated by how support healing, preserving ideal moisture levels, promoting cellular migration, possessing antibacterial properties. Thus, this hydrogel technology’s latest developments, emphasizing drug-loaded stimuli-responsive underscoring these advanced formulations greatly improve therapy outcomes enabling dynamic focused reactions environment. Future directions research promote development customized treatments digital health tools treatment wounds.

Language: Английский

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Stimuli-Responsive Drug Delivery Systems for Inflammatory Skin Conditions

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 187, P. 1 - 19

Published: Aug. 28, 2024

Inflammatory skin conditions highly influence the quality of life patients suffering from these disorders. Symptoms include red, itchy and painful lesions, which are visible to rest world, causing stigmatization a significantly lower mental health patients. Treatment options often unsatisfactory, as they suffer either low patient adherence or risk severe side effects. Considering this, there is need for new treatments, notably ways delivering drugs. Stimuli-responsive drug delivery systems able deliver their cargo in response given stimulus are, thus, promising treatment inflammatory conditions. For example, use external stimuli such ultraviolet light, near infrared radiation, alteration magnetic field enables release be precisely controlled space time. On other hand, internal induced by pathological condition, including pH upregulation reactive oxygen species enzymes, can utilized create that specifically target diseased achieve better efficacy safety. In latter context, however, it key importance match trigger mechanism system actual features specific condition. Hence, focus this article placed not only on reviewing stimuli-responsive developed treat conditions, but also critically evaluating context diseases. STATEMENT OF SIGNIFICANCE: Skin diseases affect one-third world's population, lowering patients, who deal with symptoms well due visibility symptoms. Current treatments hampered serious Therefore, more emphasis should developing innovative formulations provide safety hold considerable promise regard, where when needed, reducing adverse effects potentially offering outcomes.

Language: Английский

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One-Pot Synthesis of Fe(III)-Curcumin Coordination Polymer Nanoparticles with Dynamic Disassembly and Elimination Abilities for Cancer Therapy

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

Language: Английский

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Activity-Based Dicyanoisophorone Derivatives: Fluorogenic Toolbox Enables Direct Visualization and Monitoring of Esterase Activity in Tumor Models

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(45), P. 18278 - 18286

Published: Nov. 1, 2024

The visualization and spatiotemporal monitoring of endogenous esterase activity are crucial for clinical diagnostics treatment liver diseases. Our research adopts a novel substrate hydrolysis-enzymatic (SHEA) approach using dicyanoisophorone-based fluorogenic ester substrates DCIP-R (R = R1–R6) to evaluate preferences on diverse libraries. Esterase-mediated hydrolysis yielded fluorescent DCIP–OH with nanomolar detection limit in vitro. These probes effectively monitor kinetics turnover number 4.73 s–1 catalytic efficiency (kcat/Km) 106 M–1 (DCIP-R1). Comparative studies utilizing two-photon imaging have indicated that containing alkyl groups (DCIP-R1) as recognition elements exhibit enhanced enzymatic cleavage compared those phenyl substitution chains (DCIP-R4). Time-dependent variations levels were tracked healthy tumor models, especially diethylnitrosamine (DEN)–induced tumors HepG2-transplanted tumors. Overall, fluorescence signal quantifications demonstrated the excellent proficiency DCIP-R1 detecting both vitro vivo, showing promising potential biomedical applications.

Language: Английский

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Thermosensitive liposome-encapsulated gold nanocage for photothermal-modulated drug release and synergistic photothermal therapy

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

Using gold nanocages as carriers and thermo-sensitive liposome a protective shell, camptothecin-loaded delivery nanosystem was designed for photothermal-modulated drug release, achieving safe reliable photothermal therapy chemotherapy.

Language: Английский

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